Author(s): London-Nadeau K; Barborini C; Haines-Saah R; Bazarov M; Bristowe S; Khorkhordina M; Lemay-Gaulin M; Gorka C; Juster RP; D' Alessio H; Chadi N;

Efforts to control, repress, and punish drug use and queer and trans existence are rising as right-wing extremism becomes increasingly mainstream. These connected efforts are seen through the stifling of bodily autonomy and agency using criminal-legal, biomedical and political apparatuses, and ha ...

Article GUID: 40633507

Author(s): Andrade-Gagnon B; Casillas-Popova SN; Oh JK;

Well-defined acid-degradable amphiphilic block copolymers (ABPs) and their nanoassemblies labeled with acid-labile groups have been developed for smart drug delivery, exhibiting controlled/enhanced release of therapeutics in tumoral tissues and endo/lysosomes. In general, controlled polymerization techniques, particularly atom transfer radical polymerizat ...

Article GUID: 40614241

Author(s): Eskandari K; Bélanger SM; Lachance V; Kourrich S;

Neurodegenerative disorders, such as Alzheimer's, Parkinson's, and Huntington's disease, due to their multifaced and complicated nature, remain uncurable and impose substantial financial and human burdens on society. Therefore, developing new innovative therapeutic strategies is vital. In this context, drug repurposing has emerged as a promisi ...

Article GUID: 40430519

Author(s): Zolopa C; Clifasefi SL; Dobischok S; Gala N; Fraser-Purdy H; Phillips MK; Blackmore S; Wendt DC;

Background: There is a great diversity of traditions, practices, and experiences among the Indigenous Peoples of North America and Oceania. However, Indigenous Peoples across these regions are affected by the historical and ongoing violence of settler colonialism, resulting in disproportionately ...

Article GUID: 39970577

Author(s): He S; Singh D; Helfield B;

Gene therapy targeting ischemic heart disease is a promising therapeutic avenue, but it is mostly restricted to viral-based delivery approaches which are limited due to off-target immunological responses. Focused ultrasound presents a non-viral, image-guided technique in which circulating intravascular microbubble contrast agents can reversibly enhance va ...

Article GUID: 39850318

Author(s): Patrick Viet-Quoc N; Thien Thanh DV; Philippe L; Sebastien C; Lidia S; Philippe D;

Objective: This systematic review and meta-analysis evaluates the efficacy in improving sleep quality and safety of hypnotics in individuals aged 65 years or older compared to those under 65 years. Methods: MEDLINE, EMBASE, Web of Science, and EBM Reviews were searched for randomized clinical trials comparing hypnotics to the placebo in adults with chron ...

Article GUID: 39603114

Author(s): Ghazikhani H; Butler G;

Ion channels are critical membrane proteins that regulate ion flux across cellular membranes, influencing numerous biological functions. The resource-intensive nature of traditional wet lab experiments for ion channel identification has led to an increasing emphasis on computational techniques. This study extends our previous work on protein language mode ...

Article GUID: 39572876

Author(s): Casillas-Popova SN; Lokuge ND; Andrade-Gagnon B; Chowdhury FR; Skinner CD; Findlay BL; Oh JK;

Recent advances in the treatment of chronic wounds have focused on the development of effective strategies for cutting-edge wound dressings based on nanostructured materials, particularly biocompatible poly(vinyl alcohol) (PVA)-based electro-spun (e-spun) nanofibers. However, PVA nanofibers need ...

Article GUID: 38989606

Author(s): Memari E; Helfield B;

The recent and exciting success of anti-inflammatory therapies for ischemic heart disease (e.g. atherosclerosis) is hindered by the lack of site-specific and targeted therapeutic deposition. Microbubble-mediated focused ultrasound, which uses circulating, lipid-encapsulated intravascular microbubbles to locally enhance endothelial permeability, offers an ...

Article GUID: 38988819

Author(s): Ghazikhani H; Butler G;

This study introduces TooT-PLM-ionCT, a comprehensive framework that consolidates three distinct systems, each meticulously tailored for one of the following tasks: distinguishing ion channels (ICs) from membrane proteins (MPs), segregating ion transporters (ITs) from MPs, and differentiating ICs from ITs. Drawing upon the strengths of six Protein Languag ...

Article GUID: 38656743

Author(s): Leyton M; Nikolic M;

No abstract available

Article GUID: 38129315