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BOLD Long-Range Temporal Correlations Reflect Changes in Language and Depression Across Intensive Aphasia Therapy

Author(s): Jäger AP; Steele CJ; Dreyer FR; Osterloh MR; Sadlon A; Nikulin V; Mohr B; Pulvermüller F;

Background: Intensive language-action therapy treats language deficits and depressive symptoms in chronic poststroke aphasia, yet the underlying neural mechanisms remain underexplored. Long-range temporal correlations (LRTCs) in blood oxygenation level-dependent signals indicate persistence in brain activity patterns and may relate to learning and levels ...

Article GUID: 40927858


Internalizing symptoms are indirectly associated with simultaneous alcohol and cannabis use through specific motives for simultaneous use: A longitudinal study of young adults

Author(s): Wardell JD; Farrelly KN; Moore A; Fox N; Coelho SG; Cunningham JA; O' Connor RM; Hendershot CS;

Background: This study examined motivational pathways between internalizing symptoms (i.e., depression, anxiety, stress) and simultaneous alcohol and cannabis use among young adults. Methods: Participants (N = 151; 64% female, Mean age = 22.07) completed baseline questionnaires assessing interna ...

Article GUID: 40923811


Assessing in silico tools for accurate pathogenicity prediction in CHD nucleosome remodelers

Author(s): Rabouhi N; Guindon S; Coleman EA; van Heesbeen HJ; Greenwood CMT; Lu T; Campeau PM;

Chromodomain Helicase DNA-binding (CHD) proteins compose a family of chromatin remodelers that play crucial roles in DNA repair and gene expression regulation, neural stem cell differentiation and chromatin integrity. Genetic variants in CHD chromatin remodelers are associated with neurodevelopmental disorders with features like autism spectrum disorder a ...

Article GUID: 40907936


How do we know that they actually use it? Exploring measures of adherence to stress management strategies in university students: A systematic review

Author(s): Bastien L; Cho S; Petrovic J; Khoury B; Bloom E; Heath N;

University students are reporting high levels of stress that interfere with their academic performance and daily functioning. In response, higher education institutions have increasingly implemented digital, self-guided stress management resources to provide students with accessible mental health support. While these interventions show promise for improvi ...

Article GUID: 40895119


A novel span and syntax enhanced large language model based framework for fine-grained sentiment analysis

Author(s): Zou H; Wang Y; Huang A;

Fine-grained aspect-based sentiment analysis requires language models to identify aspect entities and the corresponding sentiment information in the input text content. Transformer-based pre-trained large language models have demonstrated remarkable performance on various challenging natural language processing tasks. However, large language models face l ...

Article GUID: 40876298


ASSOBRAFIR clinical practice guidelines in cardiovascular physical therapy: Exercise-based interventions in outpatient rehabilitation programs for heart failure

Author(s): Karsten M; Gardenghi G; Arruda ACT; Catai AM; Vieira AM; Stein C; de Araujo CLP; Pereira DAG; Matte DL; da Silva FMF; Guimarães FS; Ghisi GLM; Chiappa GRS; Sbruzzi G; Cipriano GFB; Ribeiro GDS; Milani JGPO; Neves LMT; Calegari L; Morais ...

Background: Exercise training is a core component of cardiovascular rehabilitation programs for patients with heart failure (HF). In Brazil, physical therapists frequently deliver rehabilitation interventions. Given heart failure clinical management advancements and varied rehabilitation approach ...

Article GUID: 40857977


Deep learning-based feature discovery for decoding phenotypic plasticity in pediatric high-grade gliomas single-cell transcriptomics

Author(s): Abicumaran Uthamacumaran

Advancements in AI-powered systems medicine have revolutionized biomarker discovery through emergent and explainable features. By use of complex network dynamics and graph-based machine learning, we identified critical determinants of lineage-specific plasticity across the single-cell transcriptomics of pediatric high-grade glioma (pHGGs) subtypes: IDHWT ...

Article GUID: 40848317


Understanding the environmental fate and risks of organophosphate esters: Challenges in linking precursors, parent compounds, and derivatives

Author(s): Li Z; Chen R; Xing C; Zhong G; Zhang X; Jones KC; Zhu Y;

Organophosphate esters (OPEs) have emerged as a global environmental and health concern due to their persistent, bioaccumulative, and toxic (PBT) properties. Recently, their precursors-organophosphite antioxidants (OPAs)-and transformation products, which may exhibit greater persistence and toxicity, have gained attention as critical contributors to OPE-r ...

Article GUID: 40845576


Development, Testing, and Application of an Enhanced Oil Spill Model for Ice-Covered Waters (OSMT-Ice) through Multiscale Field Experiments

Author(s): Yang Z; Chen Z; Lee K;

Amid growing concerns about oil spills in vulnerable Arctic and sub-Arctic regions driven by climate-induced ice retreat, this study presents the development and validation of the OSMT-ice model, an enhanced oil spill modeling system designed to predict the movement and fate of oil in ice-covered waters. The model incorporates ice-concentration-based (ICB ...

Article GUID: 40845360


Feasibility analysis of recycling and repurposing end-of-life vehicle batteries in isolated island areas: A case study in British Columbia, Canada

Author(s): Wang Z; Lyu L; Huang G; An C;

The increasing adoption of electric vehicles (EVs) is widely recognized as a pivotal strategy for mitigating climate change. However, the surge in EV usage brings significant challenges regarding the end-of-life management of lithium-ion batteries, particularly in geographically isolated islands, such as Vancouver Island, Canada. This study addresses the ...

Article GUID: 40795495


Artificial intelligence-assisted identification of condensing osteitis and idiopathic osteosclerosis on panoramic radiographs

Author(s): Yuksel IB; Boudesh A; Ghanbarzadehchaleshtori M; Ozsoy SC; Bahrilli S; Mohammadi R; Altindag A;

Idiopathic osteosclerosis (IOS) and condensing osteitis (CO) represent radiopaque lesions often detected incidentally within the jaws, posing substantial diagnostic challenges due to their overlapping radiographic characteristics. The objective of this study was to assess the diagnostic efficacy ...

Article GUID: 40790082


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