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Cognitive-behavioural therapy for insomnia mechanism of action: Exploring the homeostatic K-complex involvement

Author(s): Sforza M; Morin CM; Dang-Vu TT; Pomares FB; Perrault AA; Gouin JP; Bušková J; Janku K; Vgontzas A; Fernandez-Mendoza J; Bastien CH; Riemann D; Baglioni C; Carollo G; Casoni F; Zucconi M; Castronovo V; Galbiati A; Ferini-Strambi L;

Investigating the mechanisms of action of cognitive-behavioural therapy for insomnia (CBT-I), the first-line treatment for chronic insomnia disorder (ID), can contribute to the overall understanding of insomnia and its treatment. To date, no study has examined the relationship between K-complexes ...

Article GUID: 39739397


AP-1 contributes to endosomal targeting of ubiquitin ligase RNF13 via a secondary and novel non-canonical binding motif

Author(s): Cabana VC; Sénécal AM; Bouchard AY; Kourrich S; Cappadocia L; Lussier MP;

Cellular trafficking between organelles is typically assured by short motifs that contact carrier proteins to transport them to their destination. Ubiquitin E3 ligase RING finger protein 13 (RNF13), a regulator of proliferation, apoptosis, and protein trafficking, localizes to endolysosomal compartments through the binding of a dileucine motif to clathrin ...

Article GUID: 39206621


Microhabitat conditions drive uncertainty of risk and shape neophobic responses in Trinidadian guppies, Poecilia reticulata

Author(s): Feyten LEA; Ramnarine IW; Brown GE;

In response to uncertain risks, prey may rely on neophobic phenotypes to reduce the costs associated with the lack of information regarding local conditions. Neophobia has been shown to be driven by information reliability, ambient risk and predator diversity, all of which shape uncertainty of risk. We similarly expect environmental conditions to shape un ...

Article GUID: 37753307


TRAPPC6B biallelic variants cause a neurodevelopmental disorder with TRAPP II and trafficking disruptions

Author(s): Almousa H; Lewis SA; Bakhtiari S; Nordlie SH; Pagnozzi A; Magee H; Efthymiou S; Heim JA; Cornejo P; Zaki MS; Anwar N; Maqbool S; Rahman F; Neilson DE; Vemuri A; Jin SC; Yang XR; Heidari A; van Gassen K; Trimouille A; Thauvin-Robinet C; L ...

Highly conserved transport protein particle (TRAPP) complexes regulate subcellular trafficking pathways. Accurate protein trafficking has been increasingly recognized to be critically important for normal development, particularly in the nervous system. Variants in most TRAPP complex subunits hav ...

Article GUID: 37713627


Cooperative Sensitization Upconversion in Solution Dispersions of Co-Crystal Assemblies of Mononuclear Yb3+ and Eu3+ Complexes

Author(s): Sun G; Xie Y; Wang Y; Mandl GA; Maurizio SL; Zhang H; Ottenwaelder X; Capobianco JA; Sun L;

Lanthanide upconversion luminescence in nanoparticles has prompted continuous breakthroughs in information storage, temperature sensing, and biomedical applications, among others. Achieving upconversion luminescence at the molecular scale is still a critical challenge in modern chemistry. In this ...

Article GUID: 37040148


Invariant Pattern Recognition with Log-Polar Transform and Dual-Tree Complex Wavelet-Fourier Features

Author(s): Chen G; Krzyzak A;

In this paper, we propose a novel method for 2D pattern recognition by extracting features with the log-polar transform, the dual-tree complex wavelet transform (DTCWT), and the 2D fast Fourier transform (FFT2). Our new method is invariant to translation, rotation, and scaling of the input 2D pattern images in a multiresolution way, which is very importan ...

Article GUID: 37112182


Rheological Assessment of Oil-Xanthan Emulsions in Terms of Complex, Storage, and Loss Moduli

Author(s): Ghannam MT; Selim MYE; Zekri AY; Esmail N;

This experimental assessment was carried out to study the viscoelastic performance of crude oil-xanthan emulsions employing a RheoStress RS100 rheometer. Crude oil with a concentration range of 0-75% by volume was used to prepare the oil-gum emulsions. Two xanthan gums of Sigma and Kelzan were added in the emulsions with concentration ranges of 0-104 ppm. ...

Article GUID: 36679350


EEG complexity during mind wandering: A multiscale entropy investigation

Author(s): Cnudde K; Kim G; Murch WS; Handy TC; Protzner AB; Kam JWY;

Our attention often drifts away from the ongoing task to task-unrelated thoughts, a phenomenon commonly referred to as mind wandering. Ample studies dedicated to delineating its electrophysiological correlates have revealed distinct event-related potentials (ERP) and spectral patterns associated with mind wandering. It remains less clear whether the compl ...

Article GUID: 36621593


Xylan glucuronic acid side chains fix suberin-like aliphatic compounds to wood cell walls

Author(s): Derba-Maceluch M; Mitra M; Hedenström M; Liu X; Gandla ML; Barbut FR; Abreu IN; Donev EN; Urbancsok J; Moritz T; Jönsson LJ; Tsang A; Powlowski J; Master ER; Mellerowicz EJ;

Wood is the most important repository of assimilated carbon in the biosphere, in the form of large polymers (cellulose, hemicelluloses including glucuronoxylan, and lignin) that interactively form a composite, together with soluble extractives including phenolic and aliphatic compounds. Molecular ...

Article GUID: 36600379


Surfactant-enhanced mobilization of persistent organic pollutants: Potential for soil and sediment remediation and unintended consequences

Author(s): Bolan S; Padhye LP; Mulligan CN; Alonso ER; Saint-Fort R; Jasemizad T; Wang C; Zhang T; Rinklebe J; Wang H; Siddique KHM; Kirkham MB; Bolan N;

This review aims to provide an overview of the sources and reactions of persistent organic pollutants (POPs) and surfactants in soil and sediments, the surfactant-enhanced solubilisation of POPs, and the unintended consequences of surfactant-induced remediation of soil and sediments contaminated ...

Article GUID: 36265382


A Review of Mathematical and Computational Methods in Cancer Dynamics

Author(s): Uthamacumaran A; Zenil H;

Cancers are complex adaptive diseases regulated by the nonlinear feedback systems between genetic instabilities, environmental signals, cellular protein flows, and gene regulatory networks. Understanding the cybernetics of cancer requires the integration of information dynamics across multidimensional spatiotemporal scales, including genetic, transcriptio ...

Article GUID: 35957879


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