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The PREVENT-AD cohort: accelerating Alzheimer s disease research and treatment in Canada and beyond

Author(s): Villeneuve S; Poirier J; Breitner JCS; Tremblay-Mercier J; Remz J; Raoult JM; Yakoub Y; Gallego-Rudolf J; Qiu T; Valdez AF; Mohammediyan B; Javanray M; Metz A; Sanami S; Ourry V; Wearn A; Pastor-Bernier A; Edde M; Gonneaud J; Strikwerda- ...

The PREVENT-AD is an investigator-driven study that was created in 2011 and enrolled cognitively normal older adults with a family history of sporadic AD. Participants are deeply phenotyped and have now been followed annually for more than 12 years [median follow-up 8.0 years,SD 3.1]. Multimodal ...

Article GUID: 40778177


Statistical or Embodied? Comparing Colorseeing, Colorblind, Painters, and Large Language Models in Their Processing of Color Metaphors

Author(s): Nadler EO; Guilbeault D; Ringold SM; Williamson TR; Bellemare-Pepin A; Com?a IM; Jerbi K; Narayanan S; Aziz-Zadeh L;

Can metaphorical reasoning involving embodied experience-such as color perception-be learned from the statistics of language alone? Recent work finds that colorblind individuals robustly understand and reason abstractly about color, implying that color associations in everyday language might cont ...

Article GUID: 40621800


Connected speech profiles in mild cognitive impairment reflect global cognition

Author(s): Pellerin S; Houzé B; Bedetti C; Phillips N; Brambati SM;

BackgroundMild cognitive impairment (MCI), a prodromal stage of Alzheimer's disease (AD) for many individuals, is accompanied by widespread connected speech (CS) changes (e.g., shorter CS samples, mention of fewer semantic content units, lower syntactic complexity). Nevertheless, findings on CS in MCI are heterogeneous. This heterogeneity, combined wi ...

Article GUID: 40232260


Sleep spindles and slow oscillations predict cognition and biomarkers of neurodegeneration in mild to moderate Alzheimer's disease

Author(s): Páez A; Gillman SO; Dogaheh SB; Carnes A; Dakterzada F; Barbé F; Dang-Vu TT; Ripoll GP;

Introduction: Changes in sleep physiology can predate cognitive symptoms by decades in persons with Alzheimer's disease (AD), but it remains unclear which sleep characteristics predict cognitive and neurodegenerative changes after AD onset. Methods: Using data from a prospective cohort of mild to moderate AD (n = 60), we analyzed non-rapid eye moveme ...

Article GUID: 39878233


Ingestion of polyethylene microplastics impacts cichlid behaviour despite having low retention time

Author(s): Felismino MEL; Chevallier Rufigny S; Gonzalez-Fleurant SE; Brown GE;

Microplastics, particles between 0.001 and 5 mm in diameter, are ubiquitous in the environment and their consumption by aquatic organisms is known to lead to a variety of adverse effects. However, studies on the effects of microplastics on prey fish have not shown consistent trends, with results varying across species and plastic type used. Here, we manip ...

Article GUID: 39862685


In Shift and In Variance: Assessing the Robustness of HAR Deep Learning Models Against Variability

Author(s): Khaked AA; Oishi N; Roggen D; Lago P;

Deep learning (DL)-based Human Activity Recognition (HAR) using wearable inertial measurement unit (IMU) sensors can revolutionize continuous health monitoring and early disease prediction. However, most DL HAR models are untested in their robustness to real-world variability, as they are trained on limited lab-controlled data. In this study, we isolated ...

Article GUID: 39860799


Infants' Social Evaluation of Helpers and Hinderers: A Large-Scale, Multi-Lab, Coordinated Replication Study

Author(s): Lucca K; Yuen F; Wang Y; Alessandroni N; Allison O; Alvarez M; Axelsson EL; Baumer J; Baumgartner HA; Bertels J; Bhavsar M; Byers-Heinlein K; Capelier-Mourguy A; Chijiiwa H; Chin CS; Christner N; Cirelli LK; Corbit J; Daum MM; Doan T; Dr ...

Evaluating whether someone's behavior is praiseworthy or blameworthy is a fundamental human trait. A seminal study by Hamlin and colleagues in 2007 suggested that the ability to form social evaluations based on third-party interactions emerges within the first year of life: infants preferred ...

Article GUID: 39600132


Effects of Cognition-based and Affect-based Trust Attitudes on Trust Intentions

Author(s): Gill H; Vreeker-Williamson E; Hing LS; Cassidy SA; Boies K;

Despite decades of research on trust in the workplace, researchers continue to struggle with fundamental questions regarding the conceptualization and measurement of organizational trust. To help clarify this construct, we revisit established trust definitions (Mayer et al. Academy of Management Review, 20(3), 709-734, Mayer et al., Academy of Management ...

Article GUID: 39507389


EEG-based study of design creativity: a review on research design, experiments, and analysis

Author(s): Zangeneh Soroush M; Zeng Y;

Brain dynamics associated with design creativity tasks are largely unexplored. Despite significant strides, there is a limited understanding of the brain-behavior during design creation tasks. The objective of this paper is to review the concepts of creativity and design creativity as well as their differences, and to explore the brain dynamics associated ...

Article GUID: 39148896


An Ecological Approach to Conceptual Thinking in Material Engagement

Author(s): Alessandroni N; Malafouris L; Gallagher S;

Although post-cognitivist approaches have shaken the status quo by emphasising the dynamic interactions among the brain, the body, and the environment in cognition, mainstream psychological theories continue to view concepts as primarily representational or skull-bound mental phenomena. As a result, the dynamics of action and the possible impact of materi ...

Article GUID: 39118997


Approaches to studying emotion using physiological responses to spoken narratives: A scoping review

Author(s): Savard MA; Merlo R; Samithamby A; Paas A; Coffey EBJ;

Narratives are effective tools for evoking emotions, and physiological measurements provide a means of objectively assessing emotional reactions - making them a potentially powerful pair of tools for studying emotional processes. However, extent research combining emotional narratives and physiological measurement varies widely in design and application, ...

Article GUID: 38961524


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