Sexually dimorphic role of circadian clock genes in alcohol drinking behavior
Authors: Nuria de Zavalia
Affiliations
1 Center for Studies in Behavioural Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada.
2 Center for Studies in Behavioural Neurobiology, Department of Psychology, Concordia University, Montreal, QC, Canada. shimon.amir@concordia.ca.
Description
Sex differences in alcohol use and abuse are pervasive and carry important implications for the prevention and treatment of alcohol use disorder (AUD), yet insight into underlying sexually dimorphic mechanisms is limited. Growing experimental and clinical evidence points to an important influence of circadian rhythms and circadian clock genes in the control of alcohol drinking behavior and AUD. Sex differences in the expression of circadian rhythms and in the molecular circadian clock that drive...
Keywords: Alcohol consumption; Bmal1; Clock genes; Medium spiny neurons; Per2; Sex differences; Striatum;
Links
PubMed: https://pubmed.ncbi.nlm.nih.gov/36184679/
DOI: 10.1007/s00213-022-06247-w