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Translating Evidence-Based Self-Management Interventions Using a Stepped-Care Approach for Patients With Cancer and Their Caregivers: A Pilot Sequential Multiple Assignment Randomized Trial Design

Author(s): Lambert S; Moodie EEM; McCusker J; Lokhorst M; Harris C; Langmuir T; Belzile E; Laizner AM; Brahim LO; Wasserman S; Chehayeb S; Vickers M; Duncan L; Esplen MJ; Maheu C; Howell D; de Raad M;

Background: Self-directed interventions are cost-effective for patients with cancer and their family caregivers, but barriers to use can compromise adherence and efficacy. Aim: Pilot a Sequential Multiple Assignment Randomized Trial (SMART) to develop a time-varying dyadic self-management interv ...

Article GUID: 39763142


Platform capitalisms and platform cultures

Author(s): Steinberg M; Zhang L; Mukherjee R;

This article argues for a pluralization of the "platform capitalism" framework, suggesting we should think instead in terms of "platform capitalisms." This pluralization opens the way to a better account of how platforms work in different geocultural contexts, with our focus being on China, India and Japan. The article first outlines several roles the sta ...

Article GUID: 39759402


Human Auditory-Motor Networks Show Frequency-Specific Phase-Based Coupling in Resting-State MEG

Author(s): Bedford O; Noly-Gandon A; Ara A; Wiesman AI; Albouy P; Baillet S; Penhune V; Zatorre RJ;

Perception and production of music and speech rely on auditory-motor coupling, a mechanism which has been linked to temporally precise oscillatory coupling between auditory and motor regions of the human brain, particularly in the beta frequency band. Recently, brain imaging studies using magnetoencephalography (MEG) have also shown that accurate auditory ...

Article GUID: 39757971


Automated abdominal aortic calcification and major adverse cardiovascular events in people undergoing osteoporosis screening: the Manitoba Bone Mineral Density Registry

Author(s): Smith C; Sim M; Ilyas Z; Gilani SZ; Suter D; Reid S; Monchka BA; Jozani MJ; Figtree G; Schousboe JT; Lewis JR; Leslie WD;

Vertebral fracture assessment (VFA) images from bone density machines enable the automated machine learning assessment of abdominal aortic calcification (ML-AAC), a marker of cardiovascular disease (CVD) risk. The objective of this study was to describe the risk of a major adverse cardiovascular ...

Article GUID: 39749990


Cognitive-behavioural therapy for insomnia mechanism of action: Exploring the homeostatic K-complex involvement

Author(s): Sforza M; Morin CM; Dang-Vu TT; Pomares FB; Perrault AA; Gouin JP; Bušková J; Janku K; Vgontzas A; Fernandez-Mendoza J; Bastien CH; Riemann D; Baglioni C; Carollo G; Casoni F; Zucconi M; Castronovo V; Galbiati A; Ferini-Strambi L;

Investigating the mechanisms of action of cognitive-behavioural therapy for insomnia (CBT-I), the first-line treatment for chronic insomnia disorder (ID), can contribute to the overall understanding of insomnia and its treatment. To date, no study has examined the relationship between K-complexes ...

Article GUID: 39739397


Modeling predicts facile release of nitrite but not nitric oxide from the thionitrate CH3SNO2 with relevance to nitroglycerin bioactivation

Author(s): Parmar V; Orabi EA; English AM; Peslherbe GH;

Nitroglycerin is a potent vasodilator in clinical use since the late 1800s. It functions as a prodrug that is bioactivated by formation of an enzyme-based thionitrate, E-Cys-NO2. This intermediate reportedly decomposes to release NO and NO2- but their relative yields remain controversial. Hence, we determined barriers for NO and NO2- production from the m ...

Article GUID: 39738238


Widespread admixture blurs population structure and confounds Lake Trout (Salvelinus namaycush) conservation even in the genomic era

Author(s): Bernos TA; Gibelli J; Michaelides S; Won H; Jeon HB; Marin K; Boguski DA; Janjua MY; Gallagher CP; Howland KL; Fraser DJ;

Intraspecific variation is important for species' long-term persistence in changing environments. Conservation strategies targeting intraspecific variation often rely on the identification of management or policy units below the species level based on biological differences among populations. ...

Article GUID: 39730611


The effect of micro-vessel viscosity on the resonance response of a two-microbubble system

Author(s): Yusefi H; Helfield B;

Clinical ultrasound contrast agent microbubbles remain intravascular and are between 1-8 µm in diameter, with a volume-weighted mean size of 2-3 µm. Despite their worldwide clinical utility as a diagnostic contrast agent, and their continued and ongoing success as a local therapeutic vector, the fundamental interplay between microbubbles - including bubbl ...

Article GUID: 39705920


Editorial: Insight in non-pharmacological treatment of pain-2023

Author(s): Geoffrey Dover

No abstract available

Article GUID: 39697557


Oil spills in coastal regions of the Arctic and Subarctic: Environmental impacts, response tactics, and preparedness

Author(s): Bi H; Wang Z; Yue R; Sui J; Mulligan CN; Lee K; Pegau S; Chen Z; An C;

Coastal areas of the Arctic and Subarctic are vulnerable to accidental oil spills, impacting the ecosystem, society, and economy. This article provides a comprehensive overview of oil spill pollution issues in cold regions, focusing on environmental impacts, oil transport and fate, coastal/shoreline response measures, and the state of current internationa ...

Article GUID: 39689468


Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA)

Author(s): Chertkow H; Phillips N; Rockwood K; Anderson N; Andrew MK; Bartha R; Beaudoin C; Bélanger N; Bellec P; Belleville S; Bergman H; Best S; Bethell J; Bherer L; Black S; Borrie M; Camicioli R; Carrier J; Cashman N; Chan S; Crowshoe L; Cuello ...

The Canadian Consortium on Neurodegeneration in Aging (CCNA) was created by the Canadian federal government through its health research funding agency, the Canadian Institutes for Health Research (CIHR), in 2014, as a response to the G7 initiative to fight dementia. Two five-year funding cycles ( ...

Article GUID: 39636028


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