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Thermal sonogenetics for adoptive cell transfer therapy

Author(s): Baez A; Hazel K; Guertin Z; Fong E; Manus MM; Kaloyannis A; Helfield B;

Adoptive cell transfer (ACT)-based immunotherapy has emerged as a transformative approach for treating cancer, offering durable responses through the ex vivo expansion and reinfusion of antigen-specific immune cells. Despite remarkable clinical successes, most notably with chimeric antigen receptor (CAR)-T cell therapy, ACT remains limited by severe toxic ...

Article GUID: 41748028


Tuning Deep Learning for Predicting Aluminum Prices Under Different Sampling: Bayesian Optimization Versus Random Search

Author(s): Alicia Estefania Antonio Figueroa

This work implements deep learning models to capture non-linear and complex data behavior in aluminum price data. Deep learning models include the long short-term memory (LSTM) and deep feedforward neural networks (FFNN). The support vector regression (SVR) is employed as a base model for comparison. Each predictive model is tuned by using two different o ...

Article GUID: 41751647


The Breast Appreciation Scale: An examination of its psychometric properties in French-Canadian women

Author(s): Maïano C; Swami V; Tylka TL; Aimé A;

Scholars are increasingly focused on women's positive, embodied "breasted experienced", which includes breast appreciation. This positive body image facet is assessed using the 9-item Breast Appreciation Scale (BrAS; Swami et al., 2022), but assessments of its psychometric properties in diverse cultural communities are limited. Here, we repo ...

Article GUID: 41740327


Using an insect for sustainable waste management of a superabundant bird

Author(s): López-Manzano C; Mahdjoub H; Arce-Valdés LR; Khelifa R;

Urban environments accumulate large volumes of fecal waste from superabundant wildlife, yet few circular strategies exist to convert this biomass into useful products. We assessed the potential of black soldier fly (BSF) larvae to bioconvert feces from the Canada goose, a common bird that creates significant fecal pollution in parks and green spaces. Fiel ...

Article GUID: 41719861


The effect of hearing ability on dual-task performance following multi-domain training in older adults with mild cognitive impairment: findings from the SYNERGIC trial

Author(s): Downey RI; Petersen BJ; Mohanathas N; Campos JL; Montero-Odasso M; Bherer L; Pichora-Fuller MK; Bray NW; Burhan AM; Camicioli R; Fraser S; Liu-Ambrose T; Lussier M; Middleton LE; Pieruccini-Faria F; Phillips NA; Li KZH;

Background: Hearing loss is one of the largest potentially modifiable risk factors for dementia and is linked with poor cognitive-motor dual-task performance (e.g., walking while performing a cognitive task). Hearing loss is more prevalent and severe in males, whereas dementia is more prevalent i ...

Article GUID: 41694460


Expanding the tracer correlation method (TCM): A performance-based framework for wider implementation in landfill methane emissions monitoring

Author(s): Abichou T; Arkian F; Howarth E; Malmir T; Hossain RI; Buntov P; Dudak Y; Risk D;

The Tracer Correlation Method (TCM), when applied to quantify landfill methane emissions, relies on previously developed stringent quality control thresholds (R2 = 0.80 and Emission Rate Deviation (ERD) = 20 %, hereafter referred to as the Gold Standard. However, these thresholds often exclude a substantial portion of the collected data, limiting wider us ...

Article GUID: 41690139


Smart Optogenetics for Real-Time Automated Control of Cardiac Electrical Activity

Author(s): Deng S; Harlaar N; Zhang J; Dekker SO; Kudryashova NN; Zhou H; Bart CI; Jin T; Derevyanko G; van Driel W; Panfilov AV; Poelma RH; de Vries AAF; Zhang G; De Coster T; Pijnappels DA;

Control theory underpins the stabilization of dynamic systems, including cardiac tissue, where disruptions in electrical conduction cause arrhythmias. Current treatments either act rapidly but without precision or deliver targeted interventions that cannot adapt in real time. We present an integr ...

Article GUID: 41684280


Cardiorespiratory fitness in relation to cerebral vascular and metabolic health in older adults with coronary artery disease

Author(s): Sanami S; Tremblay SA; Potvin-Jutras Z; Rezaei A; Sabra D; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ;

This study investigated whether higher cardiorespiratory fitness (VO2peak) is associated with better cerebral vascular and metabolic health-specifically cerebral blood flow (CBF), cerebrovascular reactivity (CVR), cerebral metabolic rate of oxygen (CMRO2), and oxygen extraction fraction (OEF) acr ...

Article GUID: 41680492


Characterizing forearm skeletal muscle composition and function in breast cancer-related lymphedema using B-mode ultrasonography

Author(s): Whyte J; Towers A; Boily M; Rosenthall L; Rivaz H; Kilgour RD;

Background: Skeletal muscle thickness, echo intensity, and quality are important morphological properties; however, little is known how these variables compare between the affected and unaffected forearms in breast cancer-related lymphedema (BCRL). Methods: Using B-mode ultrasound, we recorded the raw radiofrequency data of the affected and unaffected fo ...

Article GUID: 41674486


ADPv2: A hierarchical histological tissue type-annotated dataset for potential biomarker discovery of colorectal disease

Author(s): Yang Z; Li K; Ramandi SG; Brassard P; Khellaf A; Trinh VQ; Zhang J; Chen L; Rowsell C; Varma S; Plataniotis K; Hosseini MS;

Computational pathology (CPath) leverages histopathology images to enhance diagnostic precision and reproducibility in clinical pathology. However, publicly available datasets for CPath that are annotated with extensive histological tissue type (HTT) taxonomies at a granular level remain scarce d ...

Article GUID: 41658283


Tuned to walk: cue type, beat perception, and gait dynamics during rhythmic stimulation in aging

Author(s): Parker A; Dalla Bella S; Penhune VB; Young L; Grenet D; Li KZH;

Rhythmic auditory cueing (RAC) improves spatiotemporal gait parameters in older adults, often using isochronous rhythmic cues (i.e., with constant inter-beat-intervals). However, healthy gait contains fractal-like variability, (i.e., with persistent long-range correlations; LRC) which is disturbed when walking to isochronous cues. Embedding auditory cues ...

Article GUID: 41661338


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