Author(s): Freeman-Cole CE; Jaeger JAG;

While landscape connectivity is an important focus of Canada's conservation goals, Canadian national parks are vulnerable to habitat loss, the breaking-up of habitat patches, and a reduction in their connectivity to surrounding ecosystems. This study measured landscape fragmentation in 43 Canadian national parks and control areas throughout their hi ...

Article GUID: 42228295

Author(s): Calvano A; Xiao Y; Steidel K; Loehrer PA; Ruppert-Junck MC; Nimsky C; Timmermann L; Bopp MHA; Pedrosa DJ;

Purpose: Accurate segmentation of the subthalamic nucleus (STN) is paramount for optimising outcomes under deep brain stimulation (DBS) in Parkinson's disease (PD). Clinically available tools like Brainlab Elements (BL-E) enable automated segmentations for surgical planning, yet their spati ...

Article GUID: 42225900

Author(s): Coulter K; Dash T; Best T; Grant N; Ansaldo AI; Phillips NA;

Speaking more than one language is hypothesized to lead to greater brain resilience in aging and Alzheimer's disease, resulting in a delay in the symptom onset of Alzheimer's disease. While previous research has used structural neuroimaging measures to explore the neural underpinnings of this protective effect, few studies have used functional b ...

Article GUID: 42208339

Author(s): Clayton EJ; Smith-Uffen M; Tribble TW; Duennwald ML; Kohalmi SE;

Background: Phenylalanine is an essential aromatic amino acid that can only be synthesized de novo by microorganisms and plants. In microorganisms, phenylalanine is synthesized through the prephenate pathway, requiring the activity of a prephenate dehydratase (PDT). In plants, phenylalanine is synthesized instead mostly through the arogenate pathway, re ...

Article GUID: 42204708

Author(s): Canham SL; Richardson LR; Aaenson-Fletcher J; Weldrick R; Walsh CA;

Homelessness remains an enduring social issue, in part, due to the stigmatization of and discrimination toward people experiencing homelessness, known as homeism. Despite extant research on the topic, little is known about how homeism, enacted through stigmatization and discrimination, may occur within transitional housing programs or among older people ...

Article GUID: 42184413

Author(s): Jain P; Bayerlein C;

eXtended Reality (XR) technologies often embed ableist design assumptions, privileging hand-based interaction and vision-centric interfaces that presume a normative able-bodied user. As a result, many disabled people-including those with limited mobility or blindness-are excluded from the outset, with accessibility added only as an afterthought. We crit ...

Article GUID: 42182821

Author(s): Pinto AMV; Bhattacharyya D; da Silva MCJ; Kitagawa DAS; Dos Santos MC; Cavalcante SFA; Islam ST; LaPlante SR; Forgione P; Diz JSF; França TCC;

Three new isatin-pyridine-2-oxime hybrids (AM01-03) were synthesized and experimentally evaluated as reactivators of acetylcholinesterase (AChE) inhibited by a surrogate of the nerve agent A-242, in comparison with their 4-oxime isomers previously reported by our research group. Furthermore, th ...

Article GUID: 42171685

Author(s): Bonnieux J; Gumuchian ST; Harboun A; Trespalacios F; Bélisle KA; Haddad A; Quintus-Bosz O; McLellan A; Chester-Trudel L; Garred D; Resendes T; Hazel L; Wong SF; Ellenbogen MA;

Intranasal administration of oxytocin has been shown to enhance social cognition and reduce stress reactivity in healthy individuals, suggesting therapeutic potential for mental disorders. However, clinical trials have produced mixed results. Following a systematic search, data were extracted f ...

Article GUID: 42134427

Author(s): Kapasa RL; Grenon C; Berbiche D; Gouin JP; Vena JE; Vasiliadis HM;

Aims: This study identified sex-specific multi-trajectories of anxiety and depression symptoms among Canadians before and during the COVID-19 pandemic, and associated factors according to a public mental health framework for the surveillance of mental health. Methods: Data from 15,021 participants in the Canadian Partnership for Tomorrow's Health c ...

Article GUID: 42107659

Author(s): Rosenstein B; Bergevin M; Bobeuf F; Bherer L; Pageaux B; Roy M; Fortin M;

Background: Multimodal exercise programs do not specifically target lumbar paraspinal musculature, but incorporate aspects of different exercises to have an overall benefit. Objective: To investigate the effect of a multimodal exercise program on paraspinal muscle volume and composition, and patient outcomes in individuals with chronic low back pain (C ...

Article GUID: 42093855

Author(s): Tahvilian H; Kafieh R; Ashtari F; Swamy MNS; Ahmad MO;

Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease. Optical coherence tomography (OCT) is a non-invasive imaging technique of the retina. The thickness of the ganglion cell-inner plexiform layer (GCIPL) obtained from an OCT image is a valuable biomarker for monitoring MS. Since the functional shape (F-shape)-based technique has pro ...

Article GUID: 42076512