Author(s): Côté M; Ramos Salas X; Carrière K; Alberga AS;

Incretin-based therapies, including glucagon-like peptide-1 receptor agonists (GLP-1RAs), are approved for the treatment of type 2 diabetes, obesity, and related conditions, and have demonstrated significant benefits for individuals with these conditions. However, in recent years, public interest and demand for GLP-1RAs-often driven by media, social media ...

Article GUID: 41986775

Author(s): Kafian Safari M; Mirzae M; Gheflati B; Sharifzade M; Zuhars J; Rottoo S; Rivaz H;

Purpose: Computer- and robotic-assisted technologies improve total knee arthroplasty (TKA) through intraoperative bone registration. However, limited bone exposure restricts point collection to the distal femur, omitting key geometric features and reducing registration accuracy and the surgical outcomes. Methods: We introduce a deep learning-based method ...

Article GUID: 41984365

Author(s): Brouillette-Alarie S; Hassan G; Varela W; Danis E; Ousman S; Madriaza P; Pauls IL; Kilinc D; Pickup D; Pelzer R; Borokhovski E;

Assessment of the risk of engaging in a violent radicalization/extremism trajectory has evolved quickly in the last 10 years. Guided by what has been achieved in psychology and criminology, scholars from the field of preventing violent extremism (PVE) have tried to import key lessons from violenc ...

Article GUID: 41978672

Author(s): Ramos Salas X; Hussey B; Alberga AS; Kyle T; Small F;

Article GUID: 41945228

Author(s): Sharif-Askari Z; Atoui K; El Zein W; Rizk M; Sharif Askari E;

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the gradual destruction of cognitive and behavioral functions. Despite the continuous research efforts, there is still no cure for this disease. In recent years, researchers have investigated Porphyromonas gingivalis (P. gingivalis) as a potential cause of AD. P. gingivalis-lipo ...

Article GUID: 41940869

Author(s): Gu Y; Hsu CL; Boa Sorte Silva NC; Tam RC; Alkeridy WA; Lam K; Liu-Ambrose T;

Background: Subcortical ischemic vascular cognitive impairment (SIVCI) is characterized by white matter hyperintensities (WMH) that contribute to executive dysfunction and increased risk of Alzheimer's disease. Cognitive reserve (CR) is the brain's ability to maintain cognitive performance despite pathology. Resting-state functional connectivity ( ...

Article GUID: 41929984

Author(s): Wang Z; Su Y; Lu Z; An C;

Maritime transport is a major contributor to greenhouse gas (GHG) emissions, and ports play a critical role in shaping regional and national decarbonization pathways. This study develops a comprehensive framework to quantify both offshore and onshore GHG emissions associated with port activities and applies it to the Vancouver Fraser Port Authority (VFPA) ...

Article GUID: 41925888

Author(s): Beaulieu J; Yates MC; Fraser DJ; Cristescu ME; Derry AM;

Anthropogenic activities have led to an unprecedented crisis in freshwater biodiversity loss. The capacity to monitor the abundance of wild populations is critical to conserving biodiversity, but conventional physical specimen collection methods are invasive, costly and labour-intensive. Environmental DNA (eDNA) offers a promising alternative, being easy ...

Article GUID: 41913704

Author(s): Abraha HN; Gebre AK; Sim M; Smith C; Gilani SZ; Ilyas Z; Zarzour F; Schousboe JT; Lix LM; Binkley N; Reid S; Monchka BA; Kimelman D; Lewis JR; Leslie WD;

Background: Sagittal abdominal diameter (SAD), a measure of visceral adiposity, has been linked to major adverse cardiovascular events (MACE). However, the relationship between SAD and abdominal aortic calcification (AAC), a marker of subclinical vascular disease, and whether they independently a ...

Article GUID: 41903786

Author(s): McAnulty C; Lavoie P; Cyr S; Lavin P; Elkrief L; Richard-Devantoy S; Rizkallah E; Lespérance P; Gamin N; Lembke A; Jutras-Aswad D; Greenway K; Garel N;

Background: Alcohol use disorder and treatment-resistant depression (TRD) often co-occur, presenting a major clinical challenge with limited effective treatments. However, ketamine produces rapid antidepressant effects and has shown promise in reducing alcohol use, and acceptance and commitment t ...

Article GUID: 41857871

Author(s): Borzone Mas D; Scarabotti PA; Vaschetto PA; Alvarenga P; Vazquez M; Arim M;

Modularity and nestedness have been observed recurrently across different ecological networks, including food webs and occurrence networks. These patterns emerge from species-level processes, where interactions and occurrences are determined by niche-based and/or abundance-based mechanisms. Abundance-based processes promote nested networks with gradients ...

Article GUID: 41840807