Author(s): Lopez-Miranda IR; Sim JI; Juneau G; Wilds CJ; Beharry AA;

The DNA repair enzyme O6-Methylguanine DNA Methyltransferase (MGMT) is a major contributor in conferring resistance to alkylating agents such as temozolomide (TMZ) in cancers. The use of MGMT inhibitors can suppress resistance and enhance the efficacy of TMZ. However, current inhibitors are nonselective for cancer cells, and as a result, MGMT is also inhi ...

Article GUID: 41531960

Author(s): Andrade-Gagnon B; Casillas-Popova SN; Shamekhi M; Bairagi K; Peslherbe GH; Oh JK;

The development of acidic pH-responsive degradable amphiphilic block copolymers (ABPs) and their nanoassemblies has been extensively explored as a promising platform for tumor-targeting drug delivery and cancer therapy. Despite tremendous advances, most acidic pH-degradable ABP nanoassemblies have been designed with acid-labile groups positioned in a sing ...

Article GUID: 41524627

Author(s): Spiech C; Martínez MG; Lazzari G; Penhune V;

The pleasurable urge to move to music ("groove") has been shown to be greatest for moderately complex musical rhythms. This is thought to occur because temporal predictions from the motor system reinforce our perception of the beat when there is a balance between expectation and surprise. The supplementary motor area (SMA) has been identified as ...

Article GUID: 41511416

Author(s): Sandkuhler SE; Youngs KS; Gottipalli O; Owlett LD; Bandora MB; Naaz A; Kim E; Wang L; Wojtovich A; Gupta V; Sacher M; Mackenzie SJ;

Mutations in the TANGO2 gene are associated with a severe neurometabolic disorder in humans, often presenting with life-threatening metabolic crisis. However, the function of TANGO2 protein remains unknown. It has recently been proposed that TANGO2 transports heme within and between cells, from a ...

Article GUID: 41504601

Author(s): Gheflati B; Mirzaei M; Zuhars J; Rottoo S; Rivaz H;

Purpose: Computer-assisted surgical navigation systems have been developed to improve the precision of total knee arthroplasty (TKA) by providing real-time guidance on implant alignment relative to patient anatomy. However, surface registration remains a key source of error that can propagate through the surgical workflow. This study investigates how pati ...

Article GUID: 41495592

Author(s): Yaghoobian S; An J; Jeong DW; Hwang JH;

Artificial intelligence (AI) and machine learning (ML) are increasingly integrated into Per- and polyfluoroalkyl substances (PFAS) research; however, the field remains fragmented with substantial variation in modeling objectives. This review provides one of the most comprehensive and detailed syntheses to date of AI/ML methods across the PFAS contaminatio ...

Article GUID: 41483514

Author(s): Zhang W; Qian H; L' Heureux J; Johns G; Koehoorn M; Woodcock S;

Cost-effectiveness guidelines recommend including productivity losses in economic evaluations conducted from a societal perspective. However, work productivity loss estimates, including absenteeism and presenteeism, are lacking for a general working population. This limits the ability of researchers and decision makers to comprehensively evaluate the incr ...

Article GUID: 41469277

Author(s): Kazemiesfahani M; Dilfanian E; Monsarrat B; Hajzargarbashi S;

Drilling in aerospace one-up assembly demands high positional accuracy, strong clamping forces, and precise angular compensation to ensure quality in multi-layered stacks. Existing robotic solutions achieve these requirements but are costly, bulky, and unsuitable for flexible or collaborative environments. This work introduces the Advanced Collaborative M ...

Article GUID: 41471503

Author(s): Hollett KB; Morin AJS; Carrese-Chacra E; Cohen TR; Carbonneau N; Berthiaume MM; Felice E; Gouin JP;

Socioecological models of health view romantic relationships as micro-social systems in which spouses influence one another's health-related thoughts, feelings, and behaviors. Although prior work suggests spousal interdependence in eating behaviors, the degree of interdependence may vary as a ...

Article GUID: 41448461

Author(s): Morrison K; Pottier P; Pollo P; Ricolfi L; Williams C; Yang Y; Beillouin D; Cardoso SJ; Ferreira V; Gallagher B; Gan JL; Hao G; Keikha M; Kozlowsky-Suzuki B; Kiran Kumara TM; Latterini F; Leverkus AB; Macartney EL; Manrique SM; Martinig ...

Meta-analysis is commonly a core component of systematic reviews and has become an important method to reconcile conflicting findings, increase statistical power, and chart new research directions. However, poor reporting practices make it challenging to evaluate the validity of meta-analyses. De ...

Article GUID: 41411971

Author(s): Mussa J; Wen L; Sharafi M; Gouin JP; Rahme E; Dasgupta K;

Background: Early cardiovascular disease risk detection opportunities are limited in men, whereas gestational diabetes, gestational hypertension and preeclampsia are risk indicators in women. We hypothesised adverse pregnancy outcomes also signal risk in fathers, due to shared environments and behaviours. Methods: Our retrospective cohort study included ...

Article GUID: 41407531