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Microglial senescence in neurodegeneration: Insights, implications, and therapeutic opportunities

Author(s): Samuel Olajide T; Oyerinde TO; Omotosho OI; Okeowo OM; Olajide OJ; Ijomone OM;

The existing literature on neurodegenerative diseases (NDDs) reveals a common pathological feature: the accumulation of misfolded proteins. However, the heterogeneity in disease onset mechanisms and the specific brain regions affected complicates the unders ...

Article GUID: 39364217


How to evaluate local fit (residuals) in large structural equation models

Author(s): Rex B Kline

Consistent with reporting standards for structural equation modelling (SEM), model fit should be evaluated at two different levels, global and local. Global fit concerns the overall or average correspondence between the entire data matrix and the model, giv ...

Article GUID: 39359027


Leveraging Personal Technologies in the Treatment of Schizophrenia Spectrum Disorders: Scoping Review

Author(s): D' Arcey J; Torous J; Asuncion TR; Tackaberry-Giddens L; Zahid A; Ishak M; Foussias G; Kidd S; ...

Background: Digital mental health is a rapidly growing field with an increasing evidence base due to its potential scalability and impacts on access to mental health care. Further, within underfund ...

Article GUID: 39348196


A Humanized Yeast Model for Studying TRAPP Complex Mutations; Proof-of-Concept Using Variants from an Individual with a TRAPPC1-Associated Neurodevelopmental Syndrome

Author(s): Zykaj E; Abboud C; Asadi P; Warsame S; Almousa H; Milev MP; Greco BM; López-Sánchez M; Bratkovic D; Kachroo AH; Pérez-Jurado LA; Sacher M; ...

Variants in membrane trafficking proteins are known to cause rare disorders with severe symptoms. The highly conserved transport protein particle (TRAPP) complexes are key membrane trafficking regu ...

Article GUID: 39273027


Exploring the glycoprotein washing fluid-assisted cleanup for the restoration of oil-contaminated shorelines with environmental integrity

Author(s): Sui J; Yue R; Bi H; Fu H; Yang A; Wang M; An C;

Spilled oil in ocean can spread to the shoreline and cause long-term impacts on the shoreline's ecological environment. Therefore, removing oil accumulated on shorelines is crucial. This study proposed an innovative ovalbumin (OVA) fluid-assisted method ...

Article GUID: 39260515


The effects of a 12-week combined motor control exercise and isolated lumbar extension intervention on lumbar multifidus muscle stiffness in individuals with chronic low back pain

Author(s): Tornblom A; Naghdi N; Rye M; Montpetit C; Fortin M;

Introduction: Exercise therapy is the primary endorsed form of conservative treatment for chronic low back pain (LBP). However, there is still conflicting evidence on which exercise intervention is best. While motor control exercise can lead to morphologica ...

Article GUID: 39258113


Measurement invariance and differential item functioning of the functionality appreciation scale (FAS) in Colombia and Spain

Author(s): Mebarak M; Maïano C; Mendoza J; Zamora Á; Baños R; Desdentado L; Miragall M; Herrero R; Swami V; ...

The Functionality Appreciation Scale (FAS) is increasingly used in diverse national and linguistic contexts. However, limited work has assessed the extent to which the instrument demonstrates measu ...

Article GUID: 39244790


Microfluidic Wound-Healing Assay for Comparative Study on Fluid Dynamic, Chemical and Mechanical Wounding on Microglia BV2 Migration

Author(s): Yazdanpanah Moghadam E; Sonenberg N; Packirisamy M;

Microglial cells, or brain immune cells, are highly dynamic and continuously migrate in pathophysiological conditions. Their adhesion, as a physical characteristic, plays a key role in migration. In this study, we presented a microfluidic chip combination o ...

Article GUID: 39203655


Transcriptional and secretome analysis of Rasamsonia emersonii lytic polysaccharide mono-oxygenases

Author(s): Raheja Y; Singh V; Kumar N; Agrawal D; Sharma G; Di Falco M; Tsang A; Chadha BS;

The current study is the first to describe the temporal and differential transcriptional expression of two lytic polysaccharide monooxygenase (LPMO) genes of Rasamsonia emersonii in response to various carbon sources. The mass spectrometry based secretome a ...

Article GUID: 39167166


EEG-based study of design creativity: a review on research design, experiments, and analysis

Author(s): Zangeneh Soroush M; Zeng Y;

Brain dynamics associated with design creativity tasks are largely unexplored. Despite significant strides, there is a limited understanding of the brain-behavior during design creation tasks. The objective of this paper is to review the concepts of creativ ...

Article GUID: 39148896


Identifying personalized barriers for hypertension self-management from TASKS framework

Author(s): Yang J; Zeng Y; Yang L; Khan N; Singh S; Walker RL; Eastwood R; Quan H;

Objective: Effective management of hypertension requires not only medical intervention but also significant patient self-management. The challenge, however, lies in the diversity of patients' personal barriers to managing their condition. The objective ...

Article GUID: 39143621


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