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BOLD Long-Range Temporal Correlations Reflect Changes in Language and Depression Across Intensive Aphasia Therapy

Author(s): Jäger AP; Steele CJ; Dreyer FR; Osterloh MR; Sadlon A; Nikulin V; Mohr B; Pulvermüller F;

Background: Intensive language-action therapy treats language deficits and depressive symptoms in chronic poststroke aphasia, yet the underlying neural mechanisms remain underexplored. Long-range temporal correlations (LRTCs) in blood oxygenation level-dependent signals indicate persistence in brain activity patterns and may relate to learning and levels ...

Article GUID: 40927858


Luminescent Electro-Spun Nanofibers Crosslinked with Boronic Esters Exhibiting Controlled Release of Carbon Dots for Detection of Wound pHs and Enhanced Antimicrobial

Author(s): Lokuge ND; Casillas-Popova SN; Singh P; Clermont-Paquette A; Skinner CD; Findlay BL; Naccache R; Oh JK;

Timely and accurate assessment of wounds during the healing process is crucial for proper diagnosis and treatment. Conventional wound dressings lack both real-time monitoring capabilities and active therapeutic functionalities, limiting their effectiveness in dynamic wound environments. Herein, w ...

Article GUID: 40920389


An examination of the quinic acid utilization genes in Aspergillus niger reveals the involvement of two pH-dependent permeases

Author(s): Sgro M; Reid ID; Arentshorst M; Ram AFJ; Tsang A;

Many microorganisms are able to use plant-derived aromatic and cyclic compounds like the common plant secondary metabolite quinic acid as carbon and energy sources. In fungi, three enzymatic steps convert quinic acid into the common intermediate protocatechuic acid, which is then further converted into TCA cycle intermediates. The genes encoding these thr ...

Article GUID: 40853219


Deep learning-based feature discovery for decoding phenotypic plasticity in pediatric high-grade gliomas single-cell transcriptomics

Author(s): Abicumaran Uthamacumaran

Advancements in AI-powered systems medicine have revolutionized biomarker discovery through emergent and explainable features. By use of complex network dynamics and graph-based machine learning, we identified critical determinants of lineage-specific plasticity across the single-cell transcriptomics of pediatric high-grade glioma (pHGGs) subtypes: IDHWT ...

Article GUID: 40848317


Dopamine inhibits excitatory synaptic responses in layer I of the rat parasubiculum

Author(s): Carter F; Hobishi H; Chapman CA;

The parasubiculum is a component of the hippocampal formation that projects to the entorhinal cortex and plays an important role in spatial navigation. Dopamine has marked effects on excitatory synaptic transmission in the hippocampus and entorhinal cortex, and the present study investigated the effects of dopamine on evoked field excitatory postsynaptic ...

Article GUID: 40818632


Feasibility analysis of recycling and repurposing end-of-life vehicle batteries in isolated island areas: A case study in British Columbia, Canada

Author(s): Wang Z; Lyu L; Huang G; An C;

The increasing adoption of electric vehicles (EVs) is widely recognized as a pivotal strategy for mitigating climate change. However, the surge in EV usage brings significant challenges regarding the end-of-life management of lithium-ion batteries, particularly in geographically isolated islands, such as Vancouver Island, Canada. This study addresses the ...

Article GUID: 40795495


An analytical framework to decode socioeconomic interplays in pesticides and fertilizer container collection patterns using land dynamics metrics

Author(s): Chowdhury R; Karimi N; Xu X; An C; Gitifar A; Ng KTW;

This study analyzes pesticide and fertilizer container collection trends across Canadian agricultural regions over a seven-year period from 2016 to 2022 through an analytical framework and proposed two land metrics. A 28.3 % decrease in the collection of small empty pesticide and fertilizer containers (EPFCs) coincides with a 41.4 % increase in the collec ...

Article GUID: 40795518


Prevalent vertebral fracture is associated with incident cardiovascular disease events in older individuals referred for bone densitometry

Author(s): Schousboe JT; Monchka BA; Davidson JM; Kimelman D; Gilani SZ; Ilyas Z; Reid S; Lewis JR; Leslie WD;

Background: It is unknown if prevalent vertebral fracture (PVFx) captured on bone density vertebral fracture assessment (VFA) images predicts incident CVD events. Methods: 11,760 individuals (mean [SD] age 75.7 [6.8] years, 94 % female) had VFA contemporaneously with bone densitometry in Manitob ...

Article GUID: 40759230


Disentangling prediction error and value in a formal test of dopamine s role in reinforcement learning

Author(s): Usypchuk AA; Maes EJP; Lozzi M; Avramidis DK; Schoenbaum G; Esber GR; Gardner MPH; Iordanova MD;

The discovery that midbrain dopamine (DA) transients can be mapped onto reward prediction errors (RPEs), the critical signal that drives learning, is a landmark in neuroscience. Causal support for the RPE hypothesis comes from studies showing that stimulating DA neurons can drive learning under c ...

Article GUID: 40738112


The longitudinal effects of global and regional brain measurements on cognitive abilities

Author(s): Hosseininasabnajar F; Kakinami L;

Loss of brain tissues and cognitive abilities are natural processes of aging, but longitudinal studies are limited. We explored the longitudinal association between global and regional brain measures with cognitive abilities among individuals with normal cognitive status, mild cognitive impairment, and Alzheimer's Disease, including those with stable ...

Article GUID: 40739300


Post-subsidy Era: Potential for Carbon Pricing in Industrial Fisheries among Global Major Fishing Countries

Author(s): Peng H; Hao J; Lyu L; Wan S; An C;

Industrial fishing's harmful subsidies fuel both a fish stock crisis and rising greenhouse gas emissions, even as calls for a global ban by the World Trade Organization persist amid slow progress. This study employs the framework of climate policy stringency assessment to examine fisheries subsidy reform through a carbon pricing lens. Using emissions, ...

Article GUID: 40737555


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