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Smart Optogenetics for Real-Time Automated Control of Cardiac Electrical Activity

Author(s): Deng S; Harlaar N; Zhang J; Dekker SO; Kudryashova NN; Zhou H; Bart CI; Jin T; Derevyanko G; van Driel W; Panfilov AV; Poelma RH; de Vries AAF; Zhang G; De Coster T; Pijnappels DA;

Control theory underpins the stabilization of dynamic systems, including cardiac tissue, where disruptions in electrical conduction cause arrhythmias. Current treatments either act rapidly but without precision or deliver targeted interventions that cannot adapt in real time. We present an integr ...

Article GUID: 41684280


Cardiorespiratory fitness in relation to cerebral vascular and metabolic health in older adults with coronary artery disease

Author(s): Sanami S; Tremblay SA; Potvin-Jutras Z; Rezaei A; Sabra D; Gagnon C; Intzandt B; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ;

This study investigated whether higher cardiorespiratory fitness (VO2peak) is associated with better cerebral vascular and metabolic health-specifically cerebral blood flow (CBF), cerebrovascular reactivity (CVR), cerebral metabolic rate of oxygen (CMRO2), and oxygen extraction fraction (OEF) acr ...

Article GUID: 41680492


Characterizing forearm skeletal muscle composition and function in breast cancer-related lymphedema using B-mode ultrasonography

Author(s): Whyte J; Towers A; Boily M; Rosenthall L; Rivaz H; Kilgour RD;

Background: Skeletal muscle thickness, echo intensity, and quality are important morphological properties; however, little is known how these variables compare between the affected and unaffected forearms in breast cancer-related lymphedema (BCRL). Methods: Using B-mode ultrasound, we recorded the raw radiofrequency data of the affected and unaffected fo ...

Article GUID: 41674486


ADPv2: A hierarchical histological tissue type-annotated dataset for potential biomarker discovery of colorectal disease

Author(s): Yang Z; Li K; Ramandi SG; Brassard P; Khellaf A; Trinh VQ; Zhang J; Chen L; Rowsell C; Varma S; Plataniotis K; Hosseini MS;

Computational pathology (CPath) leverages histopathology images to enhance diagnostic precision and reproducibility in clinical pathology. However, publicly available datasets for CPath that are annotated with extensive histological tissue type (HTT) taxonomies at a granular level remain scarce d ...

Article GUID: 41658283


Tuned to walk: cue type, beat perception, and gait dynamics during rhythmic stimulation in aging

Author(s): Parker A; Dalla Bella S; Penhune VB; Young L; Grenet D; Li KZH;

Rhythmic auditory cueing (RAC) improves spatiotemporal gait parameters in older adults, often using isochronous rhythmic cues (i.e., with constant inter-beat-intervals). However, healthy gait contains fractal-like variability, (i.e., with persistent long-range correlations; LRC) which is disturbed when walking to isochronous cues. Embedding auditory cues ...

Article GUID: 41661338


Characteristics and associated weight-loss responses to the diabetes prevention program for adults with acquired brain injury: secondary analysis of two randomized control trials

Author(s): Quilico E; Alrawi S; Callender L; McShan E; Park S; Bennett M; Driver S;

Objective: Examine the association and temporal relationship between weight-loss and participant characteristics in a sample of community-dwelling adults with acquired brain injury (ABI), including cerebral vascular accident (CVA) and traumatic brain injury (TBI). Design: Secondary data analysis of a wait-list control assessor-blinded randomized control ...

Article GUID: 41610975


Examining the Acceptability and Effectiveness of a Self-Directed, Web-Based Resource for Stress and Coping in University: Randomized Controlled Trial

Author(s): Böke BN; Mettler J; Bastien L; Cho S; Heath N;

Background: University students face high levels of stress with limited support for coping and well-being. Campus mental health services are increasingly using digital resources to support students' stress management and coping capacity. However, the effectiveness of providing this support through web-based, self-directed means remains unclear. Objec ...

Article GUID: 41576346


Organic chemicals of Arctic concern in Russian coastal seas

Author(s): Min XZ; Zhang X; Xie ZY; Nikolaev A; Vorkamp K; Ma JM; Reiersen LO; Li L; Cai MH; Ren NQ; Li YF; Zhang ZF; Kallenborn R; Muir D;

Arctic ecosystems face significant threats from chemicals of global concern. Persistent organic pollutants (POPs) and polycyclic aromatic hydrocarbons (PAHs) have been consistently detected in the Arctic through decades of monitoring. POPs are known to bioaccumulate in food webs, and both POPs an ...

Article GUID: 41571477


Genetic dissection of stool frequency implicates vitamin B1 metabolism and other actionable pathways in the modulation of gut motility

Author(s): Díaz-Muñoz C; Bozzarelli I; Lopera-Maya EA; Belbasis L; Lo Faro V; Camargo Tavares L; Heredia-Fernández F; Di Lorenzo B; Sinha T; Esteban Blanco C; Favé MJ; Awadalla P; Walters RG; Bonfiglio F; Zhernakova A; Sanna S; D' Amato M;

Background: Genetic studies of stool frequency (SF), an indirect proxy for gastrointestinal transit, may reveal therapeutically tractable pathways relevant to IBS and other dysmotility disorders. Objective: To identify genes and mechanisms involved in gut motility, providing a foundation for cli ...

Article GUID: 41558814


Scientists warning: we must change paradigm for a revolution in toxicology and world food supply

Author(s): Seralini GE; Jungers G; Andersen A; Antoniou M; Aschner M; Bacon MH; Bertrand M; Bohn T; Bonfleur ML; Bücking E; Defarge N; Djemil R; Domingo JL; Douzelet J; Fagan J; Fournier T; Garcia JLY; Gil S; Hervé-Gruyer P; Hilbeck A; Hilty L; Hub ...

We propose a new paradigm, as toxicology currently lacks the proper perspective. From the 1950s to the 1970s, at least one-third of all toxicological testing in the United States, including for chemicals and drugs, was misleading scientists, and this worldwide issue persists today. Moreover, petr ...

Article GUID: 41551494


Measurement invariance and differential item functioning of the Functionality Appreciation Scale (FAS) in five latin american nations

Author(s): Mebarak M; Maïano C; Mendoza J; Chirullo V; Coneo AMC; Compte EJ; Cruz-Licea V; Góngora VC; Henríquez C; Martínez-Banfi M; Mejía Rodriguez DL; Pescetto I; Selma H; Boothroyd LG; Thornborrow T; Todd J; Swami V;

The Functionality Appreciation Scale (FAS) is increasingly used within diverse national and linguistic contexts, but assessments of its functioning across groups remains limited. To extend knowledge, we examined measurement invariance of the FAS across five Latin American nations (Argentina, Chil ...

Article GUID: 41547175


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