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A Humanized Yeast Model for Studying TRAPP Complex Mutations; Proof-of-Concept Using Variants from an Individual with a TRAPPC1-Associated Neurodevelopmental Syndrome

Author(s): Zykaj E; Abboud C; Asadi P; Warsame S; Almousa H; Milev MP; Greco BM; López-Sánchez M; Bratkovic D; Kachroo AH; Pérez-Jurado LA; Sacher M; ...

Variants in membrane trafficking proteins are known to cause rare disorders with severe symptoms. The highly conserved transport protein particle (TRAPP) complexes are key membrane trafficking regu ...

Article GUID: 39273027


Measurement invariance and differential item functioning of the functionality appreciation scale (FAS) in Colombia and Spain

Author(s): Mebarak M; Maïano C; Mendoza J; Zamora Á; Baños R; Desdentado L; Miragall M; Herrero R; Swami V; ...

The Functionality Appreciation Scale (FAS) is increasingly used in diverse national and linguistic contexts. However, limited work has assessed the extent to which the instrument demonstrates measu ...

Article GUID: 39244790


Development and psychometric evaluation of the Violation Appraisal Measure (VAM)

Author(s): Krause S; Radomsky AS;

Mental contamination refers to feelings of dirtiness and/or urges to wash that arise without direct contact with a contaminant. Cognitive models propose that this results from "serious, negative misappraisals of perceived violations". However, the specific ...

Article GUID: 39206950


Proof-of-concept testing of a mobile application-delivered mindfulness exercise for emotional eaters: RAIN delivered as a step-by-step image sequence

Author(s): Carrière K; Siemers N; Thapar S; Knäuper B;

Background: Over fifty percent of individuals with overweight and obesity are emotional eaters. Emotional eating can be theorized as a conditioned response to eat for reasons that are not associated with physiological hunger. We conducted this proof-of-conc ...

Article GUID: 39114459


'Things that shouldn't be': a qualitative investigation of violation-related appraisals in individuals with OCD and/or trauma histories

Author(s): Krause S; Radomsky AS;

Background: Cognitive models of mental contamination (i.e. feelings of internal dirtiness without contact with a contaminant) propose that these feelings arise when individuals misappraise a violation. However, an operational definition of 'violation ...

Article GUID: 38679952


Advancements in Hybrid Cellulose-Based Films: Innovations and Applications in 2D Nano-Delivery Systems

Author(s): Ramezani G; Stiharu I; van de Ven TGM; Nerguizian V;

This review paper delves into the realm of hybrid cellulose-based materials and their applications in 2D nano-delivery systems. Cellulose, recognized for its biocompatibility, versatility, and renewability, serves as the core matrix for these nanomaterials. ...

Article GUID: 38667550


Co-Development of Three Dietary Indices to Facilitate Dietary Intake Assessment of Pediatric Crohn's Disease Patients

Author(s): Harvey A.; Mannette J.; Sigall-Boneh R.; Macintyre B.; Parrott M.; Cahill L.; Connors J.; Otley A.; Haskett J.; van Limbergen J.; Grant S.; ...

Literature on dietary behaviours of the pediatric Crohn's Disease (CD) population and the relationship between dietary intake and CD activity is limited. Three dietary indices were developed an ...

Article GUID: 38634640


ALBA: a model-driven framework for the automatic generation of android location-based apps

Author(s): Gharaat M; Sharbaf M; Zamani B; Hamou-Lhadj A;

In recent years, the number of smartphone users has increased dramatically. These users download millions of apps and use them for various services. Due to the significant demand for mobile apps, developers often seek faster development methods and more eff ...

Article GUID: 38624616


Understanding Adolescents' Experiences With Menstrual Pain to Inform the User-Centered Design of a Mindfulness-Based App: Mixed Methods Investigation Study

Author(s): Gagnon MM; Brilz AR; Alberts NM; Gordon JL; Risling TL; Stinson JN;

Background: Digital interventions are increasingly popular for the provision of nonpharmacological pain interventions, but few exist for adolescents with menstrual pain. User-centered design involves incorporating users across phases of digital health inter ...

Article GUID: 38587886


Comparative Analysis of the Functions Work Groups and Informal Subgroups Carry out in Relation to their Members: The Essence, Conditions of Implementation, Effects, and Dysfunctions

Author(s): Sidorenkov AV; Borokhovski EF;

In this article, we attempt to integrate and further develop conceptual ideas about functions of small groups and the informal subgroups that arise within them in relation to their respective members, namely, the functions of: (1) creating possibilities for ...

Article GUID: 38492193


Iron Deposition and Distribution Across the Hippocampus Is Associated with Pattern Separation and Pattern Completion in Older Adults at Risk for Alzheimer's Disease

Author(s): Zhou J; Wearn A; Huck J; Hughes C; Baracchini G; Tremblay-Mercier J; Poirier J; Villeneuve S; Tardif CL; Chakravarty MM; Daugherty AM; Gauth ...

Elevated iron deposition in the brain has been observed in older adult humans and persons with Alzheimer's disease (AD), and has been associated with lower cognitive performance. We investigate ...

Article GUID: 38388425


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