Author(s): McCallum G; Burckhardt JC; He J; Hong A; Potvin-Trottier L; Tropini C;

The human gut is a dynamic environment, where changes in pH, oxygen, and osmolality influence microbiota composition and disease. Monitoring these environmental shifts is crucial for advancing gut health diagnostics and therapeutics, yet non-invasive monitoring tools remain limited. Genetically tractable commensals, including Bacteroides thetaiotaomicron, ...

Article GUID: 41610848

Author(s): Min XZ; Zhang X; Xie ZY; Nikolaev A; Vorkamp K; Ma JM; Reiersen LO; Li L; Cai MH; Ren NQ; Li YF; Zhang ZF; Kallenborn R; Muir D;

Arctic ecosystems face significant threats from chemicals of global concern. Persistent organic pollutants (POPs) and polycyclic aromatic hydrocarbons (PAHs) have been consistently detected in the Arctic through decades of monitoring. POPs are known to bioaccumulate in food webs, and both POPs an ...

Article GUID: 41571477

Author(s): Lopez-Miranda IR; Sim JI; Juneau G; Wilds CJ; Beharry AA;

The DNA repair enzyme O6-Methylguanine DNA Methyltransferase (MGMT) is a major contributor in conferring resistance to alkylating agents such as temozolomide (TMZ) in cancers. The use of MGMT inhibitors can suppress resistance and enhance the efficacy of TMZ. However, current inhibitors are nonselective for cancer cells, and as a result, MGMT is also inhi ...

Article GUID: 41531960

Author(s): Andrade-Gagnon B; Casillas-Popova SN; Shamekhi M; Bairagi K; Peslherbe GH; Oh JK;

The development of acidic pH-responsive degradable amphiphilic block copolymers (ABPs) and their nanoassemblies has been extensively explored as a promising platform for tumor-targeting drug delivery and cancer therapy. Despite tremendous advances, most acidic pH-degradable ABP nanoassemblies have been designed with acid-labile groups positioned in a sing ...

Article GUID: 41524627

Author(s): Spiech C; Martínez MG; Lazzari G; Penhune V;

The pleasurable urge to move to music ("groove") has been shown to be greatest for moderately complex musical rhythms. This is thought to occur because temporal predictions from the motor system reinforce our perception of the beat when there is a balance between expectation and surprise. The supplementary motor area (SMA) has been identified as ...

Article GUID: 41511416

Author(s): Morrison K; Pottier P; Pollo P; Ricolfi L; Williams C; Yang Y; Beillouin D; Cardoso SJ; Ferreira V; Gallagher B; Gan JL; Hao G; Keikha M; Kozlowsky-Suzuki B; Kiran Kumara TM; Latterini F; Leverkus AB; Macartney EL; Manrique SM; Martinig ...

Meta-analysis is commonly a core component of systematic reviews and has become an important method to reconcile conflicting findings, increase statistical power, and chart new research directions. However, poor reporting practices make it challenging to evaluate the validity of meta-analyses. De ...

Article GUID: 41411971

Author(s): Won Kang JR; Kim YJ; Skead K; Soave D; Evans J; Bruat V; Harwood MP; Morris Q; Matovu E; Mulindwa J; Noyes H; McLeod A; Hazelhurst S; Lombard Z; Ramsay M; Fave MJ; Awadalla P;

Clonal hematopoiesis, through the age-associated accumulation of somatic mutations in blood, is strongly associated with hematological malignancies and other chronic diseases. These mutations have largely been characterized in individuals of European ancestry or environments, and consequently, it ...

Article GUID: 41282824

Author(s): Lazzari G; Ferreri L; Cattaneo L; Penhune V; Lega C;

The ability to internally generate and maintain a rhythmic pulse, i.e., beat imagery, is a fundamental aspect of musical cognition. While recent theories propose that premotor regions support internal temporal predictions during rhythm perception and imagery, direct causal evidence remains limited. In this study, we investigated the specific contributions ...

Article GUID: 41248776

Author(s): Quirk E; Brouillard M; Ahooja A; Ballinger S; Polka L; Byers-Heinlein K; Kircher R;

Many parents have concerns about raising their children with multiple languages. However, there is a paucity of previous research regarding parental concerns about multilingual child-rearing, particularly in multilingual societies. We address this gap with a corpus-assisted discourse study of parental concerns regarding multilingual child-rearing in Quebe ...

Article GUID: 41199774

Author(s): Ranipa K; Zhu WP; Swamy MNS;

Vision Transformers (ViTs), inspired by their success in natural language processing, have recently gained attention for heart sound classification (HSC). However, most of the existing studies on HSC rely on single-stream architectures, overlooking the advantages of multi-resolution features. While multi-stream architectures employing early or late fusion ...

Article GUID: 41155032

Author(s): Khademi S; Heidarian S; Afshar P; Mohammadi A; Sidiqi A; Nguyen ET; Ganeshan B; Oikonomou A;

In this study, we propose a novel hybrid framework for assessing the invasiveness of an in-house dataset of 114 pathologically proven lung adenocarcinomas presenting as subsolid nodules on Computed Tomography (CT). Nodules were classified into group 1 (G1), which included atypical adenomatous hyp ...

Article GUID: 41150036