Author(s): Wu N; Joyal-Desmarais K; Linkins LA; Flórez ID; Bacon SL;

Background: The COVID-19 pandemic demanded evidence synthesis approaches that could keep pace with rapidly evolving science and urgent policy needs. Rapid reviews and living evidence syntheses (LES) emerged as critical methodological responses, yet limited guidance exists for teams undertaking such work, particularly regarding the operational challenges ...

Article GUID: 42282099

Author(s): Plissonneau C; Tam BT; Garneau PY; Morais JA; Piekny A; Santosa S;

Transwell co-culture systems are models for examining cellular crosstalk, but the impact of porous membrane material on myogenic outcomes remains uncharacterized. We investigated the influence of transwell membrane material on myoblast differentiation in co-culture with human primary adipocytes and in varying concentrations of insulin-transferrin-seleni ...

Article GUID: 42260998

Author(s): Peng C; Liggio J; Moussa SG; Tang Y; Johannessen C; Zhang X; Zhang Z; Li L; Harner T; Saini A; Hung H; Wentzell J; Wheeler MJ; Dabek-Zlotorzynska E; Yassine M; Liu Q; Tang M; Friel-Bartlett Z; Abdul-Sater AA;

Antioxidants added to tires to prevent degradation have recently been recognized as emerging environmental contaminants. While their acute aquatic toxicity has raised concern, these compounds are also emitted to the atmosphere and can be associated with particulate matter (PM). On PM they can r ...

Article GUID: 42191547

Author(s): Canham SL; Richardson LR; Aaenson-Fletcher J; Weldrick R; Walsh CA;

Homelessness remains an enduring social issue, in part, due to the stigmatization of and discrimination toward people experiencing homelessness, known as homeism. Despite extant research on the topic, little is known about how homeism, enacted through stigmatization and discrimination, may occur within transitional housing programs or among older people ...

Article GUID: 42184413

Author(s): Warmerdam CAR; Westra HJ; van der Graaf A; Bonder MJ; Deelen P; van Lieshout T; Landman AJ; Jesse M; Strober BJ; Boltz T; Lapinska S; Nagpal S; Xie M; Tay D; Kirsten H; Naeem H; Raghavan V; Farzeen A; Teumer A; Favé MJ; Persyn E; Tokol ...

Many non-coding variants influence complex traits and diseases through gene regulation, yet the mechanisms linking these variants to downstream biology remain poorly understood. Here, we present eQTLGen Phase 2, a comprehensive genome-wide analysis of gene expression quantitative trait loci (eQ ...

Article GUID: 42051578

Author(s): Yu S; Jin Y; Guo T; Li H; Liu W; Chen Z; Wang X; Guo J;

Biological denitrification is limited by slow nitrate (NO3-) reduction due to low electron transfer efficiency, unsatisfactory community functional efficiency and insufficient metabolic activity of microbial communities. To overcome these challenges, Ni2+ and Fe2+ were incorporated with gallic acid (GA) to form bimetallic polyphenol networks (NiFeGA BPN ...

Article GUID: 41707775

Author(s): McCallum G; Burckhardt JC; He J; Hong A; Potvin-Trottier L; Tropini C;

The human gut is a dynamic environment, where changes in pH, oxygen, and osmolality influence microbiota composition and disease. Monitoring these environmental shifts is crucial for advancing gut health diagnostics and therapeutics, yet non-invasive monitoring tools remain limited. Genetically tractable commensals, including Bacteroides thetaiotaomicro ...

Article GUID: 41610848

Author(s): Min XZ; Zhang X; Xie ZY; Nikolaev A; Vorkamp K; Ma JM; Reiersen LO; Li L; Cai MH; Ren NQ; Li YF; Zhang ZF; Kallenborn R; Muir D;

Arctic ecosystems face significant threats from chemicals of global concern. Persistent organic pollutants (POPs) and polycyclic aromatic hydrocarbons (PAHs) have been consistently detected in the Arctic through decades of monitoring. POPs are known to bioaccumulate in food webs, and both POPs ...

Article GUID: 41571477

Author(s): Lopez-Miranda IR; Sim JI; Juneau G; Wilds CJ; Beharry AA;

The DNA repair enzyme O6-Methylguanine DNA Methyltransferase (MGMT) is a major contributor in conferring resistance to alkylating agents such as temozolomide (TMZ) in cancers. The use of MGMT inhibitors can suppress resistance and enhance the efficacy of TMZ. However, current inhibitors are nonselective for cancer cells, and as a result, MGMT is also in ...

Article GUID: 41531960

Author(s): Andrade-Gagnon B; Casillas-Popova SN; Shamekhi M; Bairagi K; Peslherbe GH; Oh JK;

The development of acidic pH-responsive degradable amphiphilic block copolymers (ABPs) and their nanoassemblies has been extensively explored as a promising platform for tumor-targeting drug delivery and cancer therapy. Despite tremendous advances, most acidic pH-degradable ABP nanoassemblies have been designed with acid-labile groups positioned in a si ...

Article GUID: 41524627

Author(s): Spiech C; Martínez MG; Lazzari G; Penhune V;

The pleasurable urge to move to music ("groove") has been shown to be greatest for moderately complex musical rhythms. This is thought to occur because temporal predictions from the motor system reinforce our perception of the beat when there is a balance between expectation and surprise. The supplementary motor area (SMA) has been identified ...

Article GUID: 41511416