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Global antibiotic hotspots and risks: A One Health assessment

Author(s): Yan B; Huang F; Ying J; Zhou D; Norouzi S; Zhang X; Wang B; Liu F;

Antibiotics are increasingly prevalent in global environments, driving antimicrobial resistance and disrupting microbial cycling. These impacts pose threats to human, animal, and environmental health. Therefore, addressing this emergent issue necessitates a One Health framework that integrates these interconnected dimensions. Here we systematically review ...

Article GUID: 40469481


Repurposing Sigma-1 Receptor-Targeting Drugs for Therapeutic Advances in Neurodegenerative Disorders

Author(s): Eskandari K; Bélanger SM; Lachance V; Kourrich S;

Neurodegenerative disorders, such as Alzheimer's, Parkinson's, and Huntington's disease, due to their multifaced and complicated nature, remain uncurable and impose substantial financial and human burdens on society. Therefore, developing new innovative therapeutic strategies is vital. In this context, drug repurposing has emerged as a promisi ...

Article GUID: 40430519


Biopsychosocial risk factors for pain in early phases of pediatric cancer treatment

Author(s): Klages KL; James RN; Kain ZN; Phipps S; Alberts NM; Fortier MA;

Introduction: Cancer pain remains a significant burden among children with cancer, and many patients experience pain starting around the time of diagnosis and throughout the course of treatment. A biopsychosocial treatment approach has been recommended to improve pain management in this population; however, specific psychosocial factors that contribute to ...

Article GUID: 40365620


Self-Ambivalence Is Indirectly Associated With Obsessive-Compulsive and Eating Disorder Symptoms Through Different Feared Self-Themes

Author(s): Wilson S; Mesli N; Mehak A; Racine SE;

Objectives: Uncertainty regarding the self and fear of self have been independently identified as relevant to both obsessive-compulsive disorder (OCD) and eating disorders (EDs). The present study aimed to examine self-ambivalence (an indicator of uncertainty regarding the self often characterized by conflicting self-beliefs) as a potential transdiagnosti ...

Article GUID: 40227164


Correlations of pilot trainees brainwave dynamics with subjective performance evaluations: insights from EEG microstate analysis

Author(s): Zhao M; Law A; Su C; Jennings S; Bourgon A; Jia W; Larose MH; Bowness D; Zeng Y;

Objective: This study aims to investigate the relationship between the subjective performance evaluations on pilot trainees' aircraft control abilities and their brainwave dynamics reflected in the results from EEG microstate analysis. Specifically, we seek to identify correlations between distinct microstate patterns and each dimension included in th ...

Article GUID: 40109507


Automated abdominal aortic calcification scoring from vertebral fracture assessment images and fall-associated hospitalisations: the Manitoba Bone Mineral Density Registry

Author(s): Sim M; Gebre AK; Dalla Via J; Reid S; Jozani MJ; Kimelman D; Monchka BA; Gilani SZ; Ilyas Z; Smith C; Suter D; Schousboe JT; Lewis JR; Leslie WD;

Abdominal aortic calcification (AAC), a subclinical measure of cardiovascular disease (CVD) that can be assessed on vertebral fracture assessment (VFA) images during osteoporosis screening, is reported to be a falls risk factor. A limitation to incorporating AAC clinically is that its scoring req ...

Article GUID: 40080298


Spatial Variations of Atmospheric Alkylated Polycyclic Aromatic Hydrocarbons across the Western Pacific to the Southern Ocean: Unexpected Increasing Deposition

Author(s): Zhu FJ; Lu XM; Jia JW; Zhang X; Xing DF; Cai MH; Kallenborn R; Li YF; Muir DCG; Zhang ZF; Zhang X;

Spatial variations of atmospheric alkylated polycyclic aromatic hydrocarbons (Alk-PAHs) are key to understanding their long-range atmospheric transport (LRAT). However, limited Alk-PAHs data have hindered their LRAT characterizations on a global scale. In this study, 49 Alk-PAHs were measured in ...

Article GUID: 40025703


Imaging flow cytometry-based cellular screening elucidates pathophysiology in individuals with Variants of Uncertain Significance

Author(s): Muffels IJJ; Waterham HR; D' Alessandro G; Zagnoli-Vieira G; Sacher M; Lefeber DJ; Van der Vinne C; Roifman CM; Gassen KLI; Rehmann H; Van Haaften-Visser DY; Nieuwenhuis ESS; Jackson SP; Fuchs SA; Wijk F; van Hasselt P;

Background: Deciphering variants of uncertain significance (VUS) represents a major diagnostic challenge, partially due to the lack of easy-to-use and versatile cellular readouts that aid the interpretation of pathogenicity and pathophysiology. To address this challenge, we propose a high-through ...

Article GUID: 39920830


Recyclability and recovery of carbon from waste printed circuit boards within a circular economy perspective: A review

Author(s): Wang Z; Huang G; An C;

Waste printed circuit boards (WPCBs) are a significant component of electronic waste (e-waste) and are among the fastest-generating waste flows. The potentially negative impacts caused by e-waste on the environment and human health pose an increasingly apparent threat to people's everyday lives and well-being. The nonmetallic fraction (predominantly c ...

Article GUID: 39862821


Exposure to hate in online and traditional media: A systematic review and meta-analysis of the impact of this exposure on individuals and communities

Author(s): Madriaza P; Hassan G; Brouillette-Alarie S; Mounchingam AN; Durocher-Corfa L; Borokhovski E; Pickup D; Paillé S;

The problem: People use social media platforms to chat, search, and share information, express their opinions, and connect with others. But these platforms also facilitate the posting of divisive, harmful, and hateful messages, targeting groups and individuals, based on their race, religion, gend ...

Article GUID: 39822240


Developmental heterogeneity of school burnout across the transition from upper secondary school to higher education: A 9-year follow-up study

Author(s): Nadon L; Morin AJS; Gilbert W; Olivier E; Salmela-Aro K;

This study utilized piecewise linear growth mixture analysis to examine the developmental heterogeneity of school burnout among a sample of 513 (67.6% females) Finnish students as they transitioned from upper secondary school to higher education (ages 17-25 years). Encompassing five measurement points (two before the transition and three after), our resul ...

Article GUID: 39645324


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