Author(s): Bonnieux J; Gumuchian ST; Harboun A; Trespalacios F; Bélisle KA; Haddad A; Quintus-Bosz O; McLellan A; Chester-Trudel L; Garred D; Resendes T; Hazel L; Wong SF; Ellenbogen MA;

Intranasal administration of oxytocin has been shown to enhance social cognition and reduce stress reactivity in healthy individuals, suggesting therapeutic potential for mental disorders. However, clinical trials have produced mixed results. Following a systematic search, data were extracted fro ...

Article GUID: 42134427

Author(s): Warmerdam CAR; Westra HJ; van der Graaf A; Bonder MJ; Deelen P; van Lieshout T; Landman AJ; Jesse M; Strober BJ; Boltz T; Lapinska S; Nagpal S; Xie M; Tay D; Kirsten H; Naeem H; Raghavan V; Farzeen A; Teumer A; Favé MJ; Persyn E; Tokolyi ...

Many non-coding variants influence complex traits and diseases through gene regulation, yet the mechanisms linking these variants to downstream biology remain poorly understood. Here, we present eQTLGen Phase 2, a comprehensive genome-wide analysis of gene expression quantitative trait loci (eQTL ...

Article GUID: 42051578

Author(s): Liu-Ambrose T; Falck RS; Dao E; Crockett RA; Barha CK; Silva NCBS; Alkeridy WA; Best JR; Hsiung GR; Field TS; Madden KM; Davis JC; Ten Brinke LF; Tam RC;

Introduction: It is unknown whether progressive resistance training (PRT) improves cognitive function in adults with cerebral small vessel disease and mild cognitive impairment (i.e., subcortical vascular cognitive impairment [SVCI]). Methods: We conducted a 12-month randomized trial comparing P ...

Article GUID: 41795685

Author(s): Alicia Estefania Antonio Figueroa

This work implements deep learning models to capture non-linear and complex data behavior in aluminum price data. Deep learning models include the long short-term memory (LSTM) and deep feedforward neural networks (FFNN). The support vector regression (SVR) is employed as a base model for comparison. Each predictive model is tuned by using two different o ...

Article GUID: 41751647

Author(s): Yu S; Jin Y; Guo T; Li H; Liu W; Chen Z; Wang X; Guo J;

Biological denitrification is limited by slow nitrate (NO3-) reduction due to low electron transfer efficiency, unsatisfactory community functional efficiency and insufficient metabolic activity of microbial communities. To overcome these challenges, Ni2+ and Fe2+ were incorporated with gallic acid (GA) to form bimetallic polyphenol networks (NiFeGA BPNs) ...

Article GUID: 41707775

Author(s): Wei X; Afnan J; Avigdor T; von Ellenrieder N; Delaire É; Royer J; Ho A; Minato E; Schiller K; Jaber K; Wang YL; Moye M; Bernhardt BC; Lina JM; Grova C; Frauscher B;

Cortical oscillations across sleep-wake cycles are essential for coordinating functional brain dynamics. High-density electroencephalography (HDEEG) combined with electrical source imaging (ESI) provides a noninvasive approach to map cortical dynamics; however, its ability to capture spatial ongo ...

Article GUID: 41687693

Author(s): McCallum G; Burckhardt JC; He J; Hong A; Potvin-Trottier L; Tropini C;

The human gut is a dynamic environment, where changes in pH, oxygen, and osmolality influence microbiota composition and disease. Monitoring these environmental shifts is crucial for advancing gut health diagnostics and therapeutics, yet non-invasive monitoring tools remain limited. Genetically tractable commensals, including Bacteroides thetaiotaomicron, ...

Article GUID: 41610848

Author(s): Min XZ; Zhang X; Xie ZY; Nikolaev A; Vorkamp K; Ma JM; Reiersen LO; Li L; Cai MH; Ren NQ; Li YF; Zhang ZF; Kallenborn R; Muir D;

Arctic ecosystems face significant threats from chemicals of global concern. Persistent organic pollutants (POPs) and polycyclic aromatic hydrocarbons (PAHs) have been consistently detected in the Arctic through decades of monitoring. POPs are known to bioaccumulate in food webs, and both POPs an ...

Article GUID: 41571477

Author(s): Lopez-Miranda IR; Sim JI; Juneau G; Wilds CJ; Beharry AA;

The DNA repair enzyme O6-Methylguanine DNA Methyltransferase (MGMT) is a major contributor in conferring resistance to alkylating agents such as temozolomide (TMZ) in cancers. The use of MGMT inhibitors can suppress resistance and enhance the efficacy of TMZ. However, current inhibitors are nonselective for cancer cells, and as a result, MGMT is also inhi ...

Article GUID: 41531960

Author(s): Andrade-Gagnon B; Casillas-Popova SN; Shamekhi M; Bairagi K; Peslherbe GH; Oh JK;

The development of acidic pH-responsive degradable amphiphilic block copolymers (ABPs) and their nanoassemblies has been extensively explored as a promising platform for tumor-targeting drug delivery and cancer therapy. Despite tremendous advances, most acidic pH-degradable ABP nanoassemblies have been designed with acid-labile groups positioned in a sing ...

Article GUID: 41524627

Author(s): Spiech C; Martínez MG; Lazzari G; Penhune V;

The pleasurable urge to move to music ("groove") has been shown to be greatest for moderately complex musical rhythms. This is thought to occur because temporal predictions from the motor system reinforce our perception of the beat when there is a balance between expectation and surprise. The supplementary motor area (SMA) has been identified as ...

Article GUID: 41511416