Author(s): Lopez-Miranda IR; Sim JI; Juneau G; Wilds CJ; Beharry AA;

The DNA repair enzyme O6-Methylguanine DNA Methyltransferase (MGMT) is a major contributor in conferring resistance to alkylating agents such as temozolomide (TMZ) in cancers. The use of MGMT inhibitors can suppress resistance and enhance the efficacy of TMZ. However, current inhibitors are nonselective for cancer cells, and as a result, MGMT is also inhi ...

Article GUID: 41531960

Author(s): Vaillancourt N; Montpetit C; Rosenstein B; Fortin M;

Background: Anxiety, depression, and pain-related fears are highly prevalent among individuals with chronic low back pain (CLBP). While aquatic therapy is a promising treatment modality for CLBP, its effects on psychological factors remain poorly understood. Objective: To compare the effects of aquatic therapy (AT) versus standard care (SC) on psychologi ...

Article GUID: 41527881

Author(s): Su Y; Wang Z; Fu H; Yang A; Chen X; An C;

The 2023 wildfires caused serious riks to air quality and public health across various provinces in Canada, particularly during the period from May to June. This study aims to systematically evaluate the impact of the May-June wildfire events on air pollution in Canada using satellite Aerosol Optical Depth (AOD) data, along with the Hybrid Single-Particle ...

Article GUID: 41520990

Author(s): Hollett KB; Morin AJS; Carrese-Chacra E; Cohen TR; Carbonneau N; Berthiaume MM; Felice E; Gouin JP;

Socioecological models of health view romantic relationships as micro-social systems in which spouses influence one another's health-related thoughts, feelings, and behaviors. Although prior work suggests spousal interdependence in eating behaviors, the degree of interdependence may vary as a ...

Article GUID: 41448461

Author(s): Biglieri S; Ahmed N; Main S; Tupling OL; Vijayakumar R; Boger J; Daum C; Dupuis S; Koch M; Liu L; Lopez K; Mann J; Martin M; McAiney C; Nasir HJ; Nasir N; Pearce B; Weldrick R; Vanderlinden K; Middleton L;

Exclusion, marginalization and stigma remain common experiences for people living with dementia. Dementia capable communities offer a pathway to support the wellbeing of people living with dementia by creating spaces where people living with dementia and their care partners are supported and empo ...

Article GUID: 41432943

Author(s): Shafagh SH; Deen I; Packirisamy M;

The fabrication of conductive polymer composites (CPCs) using polydimethylsiloxane (PDMS) and poly(3,4-ethylene dioxythiophene): poly(4-styrene-sulfonate) (PEDOT: PSS) as a matrix with multi-walled carbon nanotubes (MWCNTs) and silver nanoparticles (AgNPs) as fillers was investigated to determine their potential for use in applications such as electromagn ...

Article GUID: 41424586

Author(s): Morrison K; Pottier P; Pollo P; Ricolfi L; Williams C; Yang Y; Beillouin D; Cardoso SJ; Ferreira V; Gallagher B; Gan JL; Hao G; Keikha M; Kozlowsky-Suzuki B; Kiran Kumara TM; Latterini F; Leverkus AB; Macartney EL; Manrique SM; Martinig ...

Meta-analysis is commonly a core component of systematic reviews and has become an important method to reconcile conflicting findings, increase statistical power, and chart new research directions. However, poor reporting practices make it challenging to evaluate the validity of meta-analyses. De ...

Article GUID: 41411971

Author(s): Su Y; Chen X; Guo J; Yang A;

Aerosols serve as crucial indicators of air pollution assessment, and exert significant effects on climate change, ecological environment, and human health. However, the relationship between energy consumption, a significant contributor to air pollution, and aerosols in different economic development zones in China remains understudied. This paper employs ...

Article GUID: 41308902

Author(s): Wilansky J; Cao K;

This study investigated the effectiveness of municipal waste collection policies within England and Wales by examining how variations in local waste management strategies correlate with recycling rates. Using data from 297 council districts, we analysed the impact of different policy variables (frequency of residual waste and recycling collection, sorting ...

Article GUID: 41297338

Author(s): Wolfe D; Rosenstein B; Dover G; Boily M; Fortin M;

Background: Chronic low back pain (CLBP) patients present with morphological and functional deficits to the lumbar multifidus. Electromyostimulation (EMS) can be used to improve activation and strength in atrophied skeletal muscle, but its effect on multifidus morphology and function in CLBP patients is understudied. The aims of this study were to compare ...

Article GUID: 41283552

Author(s): Shojaee L; Nafissi N; Roodposhti FN; Shakeriastani K; Shakeriastani K;

Purpose: Idiopathic granulomatous mastitis (IGM) is a chronic, relapsing inflammatory breast disease of unknown etiology. Its unpredictable course and unclear pathogenesis have made treatment a persistent clinical challenge. This study aimed to evaluate treatment outcomes in patients with IGM, focusing on extending remission periods and reducing relapse r ...

Article GUID: 41251719