Author(s): Montpetit C; Kobaisi A; Lantz JM; Chauhan RV; Anderson DB; Fortin M;

Introduction: Degenerative cervical myelopathy (DCM) is the leading cause of adult spinal cord dysfunction, often requiring surgery. However, the role of postoperative rehabilitation in optimizing patient outcomes remains unclear. Research question: What are the effects of postoperative rehabilitation on clinical outcomes following DCM surgery? Material ...

Article GUID: 41693706

Author(s): Downey RI; Petersen BJ; Mohanathas N; Campos JL; Montero-Odasso M; Bherer L; Pichora-Fuller MK; Bray NW; Burhan AM; Camicioli R; Fraser S; Liu-Ambrose T; Lussier M; Middleton LE; Pieruccini-Faria F; Phillips NA; Li KZH;

Background: Hearing loss is one of the largest potentially modifiable risk factors for dementia and is linked with poor cognitive-motor dual-task performance (e.g., walking while performing a cognitive task). Hearing loss is more prevalent and severe in males, whereas dementia is more prevalent i ...

Article GUID: 41694460

Author(s): Yang Z; Li K; Ramandi SG; Brassard P; Khellaf A; Trinh VQ; Zhang J; Chen L; Rowsell C; Varma S; Plataniotis K; Hosseini MS;

Computational pathology (CPath) leverages histopathology images to enhance diagnostic precision and reproducibility in clinical pathology. However, publicly available datasets for CPath that are annotated with extensive histological tissue type (HTT) taxonomies at a granular level remain scarce d ...

Article GUID: 41658283

Author(s): Burcheri AJ; Galvin CR; Piché N; Frett MJ; Alschuler K; Alberts NM;

Introduction: Healthcare provider pain knowledge is critical in surgical settings, where effective pain management plays a key role in the prevention of chronic postsurgical pain. Despite this, little is known about the pain training and knowledge of surgical residents. Objective: To comprehensively assess Canadian surgery residents' knowledge and at ...

Article GUID: 41635476

Author(s): Wu G; Eastwood CA; Cheligeer C; Southern DA; Zeng Y; Ghali WA; Bakal JA; Boussat B; Flemons W; Forster A; Xu Y; Quan H;

Background: While the incidence of hospital adverse events appeared to be declining before 2019, the COVID-19 pandemic may have changed its course. This study aimed to evaluate adverse event incidence rates and trends during the pandemic and analyse differences in patient outcomes. Methods: This ...

Article GUID: 41592994

Author(s): Sacco S; Booij L; Kwok C; Carrière K; Hall K; Baluyot TC; Forouhar V; Côté M; Pietrasik M; Jebeile H; Ball GDC; Johnston BC; Alberga AS;

Background: Many children and adolescents with overweight or obesity experience negative psychosocial health consequences. Systematic reviews show that behavioral interventions can help improve specific psychosocial outcomes. This scoping review aims to identify and map the different types of psy ...

Article GUID: 41601261

Author(s): Calvo N; Phillips N; Bialystok E; Einstein G;

Introduction: The relationship between biological sex, considered a risk factor for Alzheimer's disease (AD), and bilingualism, a resilience factor, is unclear. We assessed this relationship in 335 individuals with mild cognitive impairment (MCI) in a Canadian cohort. Methods: We used univariate analysis and structural equation modelling to study the ...

Article GUID: 41573422

Author(s): Seralini GE; Jungers G; Andersen A; Antoniou M; Aschner M; Bacon MH; Bertrand M; Bohn T; Bonfleur ML; Bücking E; Defarge N; Djemil R; Domingo JL; Douzelet J; Fagan J; Fournier T; Garcia JLY; Gil S; Hervé-Gruyer P; Hilbeck A; Hilty L; Hub ...

We propose a new paradigm, as toxicology currently lacks the proper perspective. From the 1950s to the 1970s, at least one-third of all toxicological testing in the United States, including for chemicals and drugs, was misleading scientists, and this worldwide issue persists today. Moreover, petr ...

Article GUID: 41551494

Author(s): Lopez-Miranda IR; Sim JI; Juneau G; Wilds CJ; Beharry AA;

The DNA repair enzyme O6-Methylguanine DNA Methyltransferase (MGMT) is a major contributor in conferring resistance to alkylating agents such as temozolomide (TMZ) in cancers. The use of MGMT inhibitors can suppress resistance and enhance the efficacy of TMZ. However, current inhibitors are nonselective for cancer cells, and as a result, MGMT is also inhi ...

Article GUID: 41531960

Author(s): Vaillancourt N; Montpetit C; Rosenstein B; Fortin M;

Background: Anxiety, depression, and pain-related fears are highly prevalent among individuals with chronic low back pain (CLBP). While aquatic therapy is a promising treatment modality for CLBP, its effects on psychological factors remain poorly understood. Objective: To compare the effects of aquatic therapy (AT) versus standard care (SC) on psychologi ...

Article GUID: 41527881

Author(s): Su Y; Wang Z; Fu H; Yang A; Chen X; An C;

The 2023 wildfires caused serious riks to air quality and public health across various provinces in Canada, particularly during the period from May to June. This study aims to systematically evaluate the impact of the May-June wildfire events on air pollution in Canada using satellite Aerosol Optical Depth (AOD) data, along with the Hybrid Single-Particle ...

Article GUID: 41520990