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Assessing in silico tools for accurate pathogenicity prediction in CHD nucleosome remodelers

Author(s): Rabouhi N; Guindon S; Coleman EA; van Heesbeen HJ; Greenwood CMT; Lu T; Campeau PM;

Chromodomain Helicase DNA-binding (CHD) proteins compose a family of chromatin remodelers that play crucial roles in DNA repair and gene expression regulation, neural stem cell differentiation and chromatin integrity. Genetic variants in CHD chromatin remodelers are associated with neurodevelopmental disorders with features like autism spectrum disorder a ...

Article GUID: 40907936


A novel span and syntax enhanced large language model based framework for fine-grained sentiment analysis

Author(s): Zou H; Wang Y; Huang A;

Fine-grained aspect-based sentiment analysis requires language models to identify aspect entities and the corresponding sentiment information in the input text content. Transformer-based pre-trained large language models have demonstrated remarkable performance on various challenging natural language processing tasks. However, large language models face l ...

Article GUID: 40876298


Dopamine inhibits excitatory synaptic responses in layer I of the rat parasubiculum

Author(s): Carter F; Hobishi H; Chapman CA;

The parasubiculum is a component of the hippocampal formation that projects to the entorhinal cortex and plays an important role in spatial navigation. Dopamine has marked effects on excitatory synaptic transmission in the hippocampus and entorhinal cortex, and the present study investigated the effects of dopamine on evoked field excitatory postsynaptic ...

Article GUID: 40818632


Artificial intelligence-assisted identification of condensing osteitis and idiopathic osteosclerosis on panoramic radiographs

Author(s): Yuksel IB; Boudesh A; Ghanbarzadehchaleshtori M; Ozsoy SC; Bahrilli S; Mohammadi R; Altindag A;

Idiopathic osteosclerosis (IOS) and condensing osteitis (CO) represent radiopaque lesions often detected incidentally within the jaws, posing substantial diagnostic challenges due to their overlapping radiographic characteristics. The objective of this study was to assess the diagnostic efficacy ...

Article GUID: 40790082


A portrait of online gambling: a look at a transformation amid a pandemic

Author(s): Kairouz S; Savard AC; Murch WS; Dixon MR; Martin NB; Brodeur M; Dauphinais S; Ferland F; Hamel D; Dufour M; French M; Monson E; Van Mourik V; Morvannou A;

Background: The COVID-19 pandemic brought about an extraordinary societal context in which the gambling offer was modified to meet public health measures intended to curb viral transmission. With many land-based gambling venues being forced to close, gambling opportunities were left almost exclus ...

Article GUID: 40770758


Land-use history causes differences in park nighttime cooling capacity and forest structure

Author(s): Richmond IC; Paulauskas MA; Padvaiskas E; Gonzàlez Sinisterra LC; Hutt-Taylor K; Robitaille AL; Ziter CD;

Cities are temporally dynamic ecosystems that experience continuous redevelopment over time. Urban parks, which provide critical benefits to resident wellbeing, are developed on different land-use types and contain natural elements that are susceptible to the effects of historical decision-making ...

Article GUID: 40761092


The longitudinal effects of global and regional brain measurements on cognitive abilities

Author(s): Hosseininasabnajar F; Kakinami L;

Loss of brain tissues and cognitive abilities are natural processes of aging, but longitudinal studies are limited. We explored the longitudinal association between global and regional brain measures with cognitive abilities among individuals with normal cognitive status, mild cognitive impairment, and Alzheimer's Disease, including those with stable ...

Article GUID: 40739300


Intolerance of uncertainty, psychological symptoms, and pain in long-term childhood cancer survivors: a report from the Childhood Cancer Survivor Study

Author(s): Alberts NM; Stratton KL; Leisenring WM; Pizzo A; Lamoureux É; Alschuler K; Flynn J; Krull KR; Jibb LA; Nathan PC; Olgin JE; Stinson JN; Armstrong GT;

Purpose: Intolerance of uncertainty is central to many psychological disorders and may contribute to pain. Despite the uncertainty inherent in childhood cancer survivorship, little is known about intolerance of uncertainty in this population. This study aimed to characterize intolerance of uncert ...

Article GUID: 40699439


24-hour activity cycle behaviors and gray matter volume in mild cognitive impairment

Author(s): Balbim GM; Boa Sorte Silva NC; Falck RS; Kramer AF; Voss MW; Liu-Ambrose T;

Introduction: The 24-hour activity cycle (24-HAC) includes physical activity (PA), sedentary behavior (SB), and sleep. The 24-HAC composition and brain health relationship in adults with mild cognitive impairment (MCI) remains underexplored. We examined associations between 24-HAC composition and gray matter (GM) volume. Methods: Cross-sectional study in ...

Article GUID: 40693459


Comparative proteomic analysis of self-compatible and self-incompatible genotypes of fennel (Foeniculum vulgare Mill.)

Author(s): Mirzahosseini Z; Shabani L; Sabzalian MR; Shojaiefar S; Dayanandan S;

In this study, a comparative proteomic analysis was conducted on four agriculturally important genotypes of fennel (Foeniculum vulgare Mill.) named Yazd, Tabriz, Varamin, and Karaj to identify effective proteins and mechanisms involved in self-incompatibility. Self-pollinated and open-pollinated seeds from each genotype were planted in separate lines. The ...

Article GUID: 40691524


Comparative Analysis of Preferences and Willingness to Pay for COVID-19 Vaccine Among Individuals With and Without Chronic Diseases: A Discrete Choice Experiment Approach

Author(s): Begum A; Uddin MA; Ahsan SM; Islam MA;

Background and aims: The rapid development and deployment of COVID-19 vaccines have been pivotal in the global battle against the pandemic. However, vaccine acceptance remains a critical determinant of their effectiveness. While numerous studies have explored factors influencing vaccine acceptance, there is a notable dearth of research regarding preferenc ...

Article GUID: 40687549


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