Author(s): Robinson TD; Sun YL; Chang PTH; Gauthier CJ; Chen JJ;

One of the most promising interventional targets for brain health is cerebral perfusion, but its link to white matter (WM) aging remains unclear. Motivated by existing literature demonstrating links between declining cortical perfusion and the development of WM hyperintensities, we posit that regional WM hypoperfusion precedes deteriorating WM integrity. ...

Article GUID: 40694306

Author(s): Robert C; Patel R; Blostein N; Steele CC; Mallar Chakravarty M;

The striatum is a major subcortical connection hub that has been heavily implicated in a wide array of motor and cognitive functions. Here, we developed a normative multimodal, data-driven microstructural parcellation of the striatum using non-negative matrix factorization (NMF) based on multiple magnetic resonance imaging-based metrics (mean diffusivity, ...

Article GUID: 34848302

Author(s): Xiao Y; Peters TM; Khan AR;

Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized by a range of motor and nonmotor symptoms, often with the motor dysfunction initiated unilaterally. Knowledge regarding disease-related alterations in white matter pathways can effectively help improve the understanding of the disease and propose targeted treatm ...

Article GUID: 34106502

Author(s): Fayed EM, Shahriari D, Saadati M, Brailovski V, Jahazi M, Medraj M

Materials (Basel). 2020 Jun 05;13(11): Authors: Fayed EM, Shahriari D, Saadati M, Brailovski V, Jahazi M, Medraj M

Article GUID: 32516909

Author(s): Patel R, Steele CJ, Chen A, Patel S, Devenyi GA, Germann J, Tardif CL, Chakravarty MM

Neuroimage. 2019 Nov 09;:116348 Authors: Patel R, Steele CJ, Chen A, Patel S, Devenyi GA, Germann J, Tardif CL, Chakravarty MM

Article GUID: 31715254