Author(s): Pinto AMV; Bhattacharyya D; da Silva MCJ; Kitagawa DAS; Dos Santos MC; Cavalcante SFA; Islam ST; LaPlante SR; Forgione P; Diz JSF; França TCC;

Three new isatin-pyridine-2-oxime hybrids (AM01-03) were synthesized and experimentally evaluated as reactivators of acetylcholinesterase (AChE) inhibited by a surrogate of the nerve agent A-242, in comparison with their 4-oxime isomers previously reported by our research group. Furthermore, th ...

Article GUID: 42171685

Author(s): Kaliamurthi S; Selvaraj G; Selvaraj C; Singh SK; Wei DQ; Peslherbe GH;

Coronavirus disease (COVID)-19 is the leading global health threat to date caused by a severe acute respiratory syndrome coronavirus (SARS-CoV-2). Recent clinical trials reported that the use of Bruton's tyrosine kinase (BTK) inhibitors to treat COVID-19 patients could reduce dyspnea and hypoxia, thromboinflammation, hypercoagulability and improve o ...

Article GUID: 34209188

Author(s): Molloy EN; Mueller K; Beinhölzl N; Blöchl M; Piecha FA; Pampel A; Steele CJ; Scharrer U; Zheleva G; Regenthal R; Sehm B; Nikulin VV; Möller HE; Villringer A; Sacher J;

The contribution of selective serotonin reuptake inhibitors to motor learning by inducing motor cortical plasticity remains controversial given diverse findings from positive preclinical data to negative findings in recent clinical trials. To empirically address this translational disparity, we ...

Article GUID: 33148103