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Global antibiotic hotspots and risks: A One Health assessment

Author(s): Yan B; Huang F; Ying J; Zhou D; Norouzi S; Zhang X; Wang B; Liu F;

Antibiotics are increasingly prevalent in global environments, driving antimicrobial resistance and disrupting microbial cycling. These impacts pose threats to human, animal, and environmental health. Therefore, addressing this emergent issue necessitates a One Health framework that integrates these interconnected dimensions. Here we systematically review ...

Article GUID: 40469481


The enterobactin biosynthetic intermediate 2,3-dihydroxybenzoic acid is a competitive inhibitor of the Escherichia coli isochorismatase EntB

Author(s): Bin X; Pawelek PD;

The Escherichia coli enterobactin biosynthetic protein EntB is a bifunctional enzyme that catalyzes hydrolysis of isochorismate via its N-terminal isochorismatase (IC) domain, and then transfers phosphopantetheinylated 2,3-DHB to EntF via the EntB C-terminal aryl carrier protein (ArCP) domain. Here we used a fluorescence anisotropy binding assay to invest ...

Article GUID: 40400396


Exosome Innovations in Ophthalmology and Sjögren s Syndrome

Author(s): Wu KY; Dave A; Nirwal GK; Giunta M; Nguyen VDH; Tran SD;

Exosomes, a subset of extracellular vesicles, have emerged as potential therapeutic agents in ophthalmology due to their ability to modulate immune responses, facilitate cellular communication, and promote tissue repair. This chapter explores the potential applications of exosome-based therapies in corneal and anterior segment disorders, retinal diseases, ...

Article GUID: 40360847


From tissue to sound: A new paradigm for medical sonic interaction design

Author(s): Matinfar S; Dehghani S; Salehi M; Sommersperger M; Navab N; Faridpooya K; Fairhurst M; Navab N;

Medical imaging maps tissue characteristics into image intensity values, enhancing human perception. However, comprehending this data, especially in high-stakes scenarios such as surgery, is prone to errors. Additionally, current multimodal methods do not fully leverage this valuable data in thei ...

Article GUID: 40222195


Hyperbranched Polyethylene Ionomers Containing Quaternary Ammonium Ions and Their Functionalization of Nanomaterials

Author(s): Ye Z; Rahmatinejad J; Raisi B; Dai P;

Ionomers containing a small number of ionic side groups are a unique class of polymers with some valuable properties and distinct applications. To date, commercially important ionomers are exclusively anionomers that contain covalently bonded anions and are synthesized commonly by radical polymerization. The catalytic synthesis of polyethylene-based catio ...

Article GUID: 40214570


Addressing vaccine hesitancy: A systematic review comparing the efficacy of motivational versus educational interventions on vaccination uptake

Author(s): Labbé S; Bacon SL; Wu N; Ribeiro PAB; Boucher VG; Stojanovic J; Voisard B; Deslauriers F; Tremblay N; Hébert-Auger L; Lavoie KL;

Traditional approaches to increase vaccination rely upon educating patients about vaccines. However, research shows that "knowing" vaccines are important is often insufficient: patients need to believe that getting vaccinated is important. Evidence-based motivational approaches, such as ...

Article GUID: 40167044


Domains of wheelchair users socio-emotional experiences: Design insights from a scoping review

Author(s): Rasoulivalajoozi M; Cucuzzella C; Farhoudi M;

Background: Physical accessibility is not the only concern for wheelchair users (WUs); they also face barriers to social presence, such as challenges in social engagement and negative stereotypes. Identifying key domains in the literature that impact their social and emotional experiences is essential to addressing these issues. Objective: This scoping r ...

Article GUID: 40164524


Overweight and obesity in early childhood and obesity at 10 years of age: a comparison of World Health Organization definitions

Author(s): Van Hulst A; Zheng S; Argiropoulos N; Ybarra M; Ball GDC; Kakinami L;

The World Health Organization recommends using + 2 SD of body mass index z-score (zBMI) to define overweight/obesity (OWO) in children ages 2 to 5 years whereas + 1 SD is used as cut-point from 5 years onwards. Empirical evidence for using different cut-points across childhood is lacking. Our objective was to compare the ability of OWO in early childhood ...

Article GUID: 40140102


Membranous translation platforms in the chloroplast of Chlamydomonas reinhardtii

Author(s): Sun Y; Bakhtiari S; Valente-Paterno M; Jiang H; Zerges W;

A small genome in chloroplasts encodes many of the polypeptide subunits of the photosynthetic electron transport complexes embedded in the membranes of thylakoid vesicles in the chloroplast stroma and synthesized by ribosomes of the bacterial-like genetic system of this semiautonomous organelle. While thylakoid membranes are sites of translation, evidence ...

Article GUID: 40116843


A synthetic model of bioinspired liposomes to study cancer-cell derived extracellular vesicles and their uptake by recipient cells

Author(s): López RR; Ben El Khyat CZ; Chen Y; Tsering T; Dickinson K; Bustamante P; Erzingatzian A; Bartolomucci A; Ferrier ST; Douanne N; Mounier C; Stiharu I; Nerguizian V; Burnier JV;

Extracellular vesicles (EVs) are secreted by most cell types and play a central role in cell-cell communication. These naturally occurring nanoparticles have been particularly implicated in cancer, but EV heterogeneity and lengthy isolation methods with low yield make them difficult to study. To ...

Article GUID: 40069225


Is There a Need to Reassess Protein Intake Recommendations Following Metabolic Bariatric Surgery?

Author(s): Ben-Porat T; Lahav Y; Cohen TR; Bacon SL; Buch A; Moizé V; Sherf-Dagan S;

Purpose of review: Protein intake is recognized as a key nutritional factor crucial for optimizing Metabolic Bariatric Surgery (MBS) outcomes by preventing protein malnutrition, preserving fat-free mass, and inducing satiety. This paper discusses the current evidence regarding protein intake and its impact on clinical outcomes following MBS. Recent findi ...

Article GUID: 39878797


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