Author(s): Rabouhi N; Guindon S; Coleman EA; van Heesbeen HJ; Greenwood CMT; Lu T; Campeau PM;

Chromodomain Helicase DNA-binding (CHD) proteins compose a family of chromatin remodelers that play crucial roles in DNA repair and gene expression regulation, neural stem cell differentiation and chromatin integrity. Genetic variants in CHD chromatin remodelers are associated with neurodevelopmental disorders with features like autism spectrum disorder a ...

Article GUID: 40907936

Author(s): Abicumaran Uthamacumaran

Advancements in AI-powered systems medicine have revolutionized biomarker discovery through emergent and explainable features. By use of complex network dynamics and graph-based machine learning, we identified critical determinants of lineage-specific plasticity across the single-cell transcriptomics of pediatric high-grade glioma (pHGGs) subtypes: IDHWT ...

Article GUID: 40848317

Author(s): Alberts NM; Stratton KL; Leisenring WM; Pizzo A; Lamoureux É; Alschuler K; Flynn J; Krull KR; Jibb LA; Nathan PC; Olgin JE; Stinson JN; Armstrong GT;

Purpose: Intolerance of uncertainty is central to many psychological disorders and may contribute to pain. Despite the uncertainty inherent in childhood cancer survivorship, little is known about intolerance of uncertainty in this population. This study aimed to characterize intolerance of uncert ...

Article GUID: 40699439

Author(s): Alves W; Babouras A; Martineau PA; Schutt D; Robbins S; Fevens T;

Concussions present a significant risk to athletes, with females exhibiting higher rates and prolonged recovery times than males. Current sideline concussion detection methods, such as the King-Devick test commonly used as a rapid screening tool designed to evaluate eye movement, attention, language, and cognitive processing abilities suffer from validity ...

Article GUID: 40632382

Author(s): AlHammad K; Medraj M; Tembely M;

Water droplet erosion (WDE) is a critical degradation phenomenon that significantly affects component lifespan and performance in power generation, aerospace, and wind energy industries. The incubation period-the initial phase before visible material loss occurs-is particularly crucial for maintenance planning and material selection yet remains challengin ...

Article GUID: 40612685

Author(s): Sobral M; Jourde HR; Marjani Bajestani SE; Coffey EBJ; Beltrame G;

Personalized closed-loop brain stimulation, in which algorithms used to detect neural events adapt to a user's unique neural characteristics, may be crucial to enable optimized and consistent stimulation quality for both fundamental research and clinical applications. Precise stimulation of sleep spindles-transient patterns of brain activity that occu ...

Article GUID: 40609549

Author(s): Bouregbi I; Bensakhri Z; Zebsa R; Zouaimia A; Bensouilah S; Bouteraa O; Khelifa R; Ouakid ML; Mahdjoub H; Houhamdi M;

Understanding the impact of climate change on waterbirds, particularly those of conservation concern, is essential for their long-term management and effective conservation. In arid regions such as North Africa, wetlands of international importance have been affected by severe drought events, but ...

Article GUID: 40566545

Author(s): Elmekki H; Islam S; Alagha A; Sami H; Spilkin A; Zakeri E; Zanuttini AM; Bentahar J; Kadem L; Xie WF; Pibarot P; Mizouni R; Otrok H; Singh S; Mourad A;

Medical Ultrasound (US) imaging has seen increasing demands over the past years, becoming one of the most preferred imaging modalities in clinical practice due to its affordability, portability, and real-time capabilities. However, it faces several challenges that limit its applicability, such as ...

Article GUID: 40567264

Author(s): Mazzocca K; Langmuir T; Manan J; Gagnon MM; Alberts NM;

TikTok is a popular social media platform increasingly used to disseminate health information and personal experiences, including among women with pain. Characterising health-related content can help understand how public perceptions are shaped and guide improvements in patient care. Although women with pain often seek information on social media, little ...

Article GUID: 40514002

Author(s): Wu KY; Dave A; Nirwal GK; Giunta M; Nguyen VDH; Tran SD;

Exosomes, a subset of extracellular vesicles, have emerged as potential therapeutic agents in ophthalmology due to their ability to modulate immune responses, facilitate cellular communication, and promote tissue repair. This chapter explores the potential applications of exosome-based therapies in corneal and anterior segment disorders, retinal diseases, ...

Article GUID: 40360847

Author(s): Klages KL; James RN; Kain ZN; Phipps S; Alberts NM; Fortier MA;

Introduction: Cancer pain remains a significant burden among children with cancer, and many patients experience pain starting around the time of diagnosis and throughout the course of treatment. A biopsychosocial treatment approach has been recommended to improve pain management in this population; however, specific psychosocial factors that contribute to ...

Article GUID: 40365620