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Validating MEG estimated resting-state connectome with intracranial EEG

Author(s): Afnan J; Cai Z; Lina JM; Abdallah C; Pellegrino G; Arcara G; Khajehpour H; Frauscher B; Gotman J; Grova C;

Magnetoencephalography (MEG) is widely used for studying resting-state brain connectivity. However, MEG source imaging is ill posed and has limited spatial resolution. This introduces source-leakage issues, making it challenging to interpret MEG-derived connectivity in resting states. To address ...

Article GUID: 40161991


Developmental exposure to the physical and social world and responses to risk among college students from four cultural contexts

Author(s): Chentsova-Dutton Y; Gürcan-Yildirim D; Wu J; Zakharov I; Ryder AG;

What are the psychological implications of developmental exposure to the physical and social environment of one's community, with its threats and rewards? The cultural shaping of enacted autonomy-or self-reliance in an environment that includes real and perceived threats-has largely been overlooked despite historical changes in this domain. Responses ...

Article GUID: 40147255


Protocol for evaluating neuronal activity and neurotransmitter release following amyloid-beta oligomer injections into the rat hippocampus

Author(s): Hervé V; Bonenfant L; Amyot M; Balafrej R; Ali OBK; Benali H; Brouillette J;

In Alzheimer's disease, there is an imbalance in neurotransmitter release and altered neuronal activation. Here, we present a protocol approach to analyze neuronal activity by combining local field potential (LFP) recording with microdialysis within the same animal. We describe steps for measuring glutamate and GABA levels following hippocampal amyloi ...

Article GUID: 40131934


The Awakening Brain is Characterized by a Widespread and Spatiotemporally Heterogeneous Increase in High Frequencies

Author(s): Avigdor T; Ren G; Abdallah C; Dubeau F; Grova C; Frauscher B;

Morning awakening is part of everyday life. Surprisingly, information remains scarce on its underlying neurophysiological correlates. Here simultaneous polysomnography and stereo-electroencephalography recordings from 18 patients are used to assess the spectral and connectivity content of the process of awakening at a local level 15 min before and after t ...

Article GUID: 40126936


Shared Dispersal Patterns but Contrasting Levels of Gene Flow in Two Anadromous Salmonids Along a Broad Subarctic Coastal Gradient

Author(s): Bouchard R; Babin C; Normandeau E; Xuereb A; Boulanger F; Coxon A; Diamond S; Fireman R; Lameboy J; Louttit N; Natawapineskum G; Okimaw D; Torio D; Varty S; Moore JS; Fraser D; Bernatchez L;

Dispersal is a highly variable trait influenced by life history and ecological factors, affecting gene flow when dispersers successfully reproduce. Anadromous salmonids, with their diverse migratory strategies and ecological traits, serve as an ideal model for studying dispersal evolution, showca ...

Article GUID: 40108992


Correlations of pilot trainees brainwave dynamics with subjective performance evaluations: insights from EEG microstate analysis

Author(s): Zhao M; Law A; Su C; Jennings S; Bourgon A; Jia W; Larose MH; Bowness D; Zeng Y;

Objective: This study aims to investigate the relationship between the subjective performance evaluations on pilot trainees' aircraft control abilities and their brainwave dynamics reflected in the results from EEG microstate analysis. Specifically, we seek to identify correlations between distinct microstate patterns and each dimension included in th ...

Article GUID: 40109507


Strategies to Reduce Uncertainties from the Best Available Physicochemical Parameters Used for Modeling Novel Organophosphate Esters across Multimedia Environments

Author(s): Xing C; Ge J; Chen R; Li S; Wang C; Zhang X; Geng Y; Jones KC; Zhu Y;

Organophosphate esters (OPEs) raise growing environmental and human health concerns globally. However, numerous novel OPEs lack data on physicochemical properties, which are essential for assessing environmental fate, exposure, and risks. This study predicted water solubility (Sw), vapor pressure (Vp), octanol-water partition coefficient (Kow), and octano ...

Article GUID: 40105294


Utilizing large language models for detecting hospital-acquired conditions: an empirical study on pulmonary embolism

Author(s): Cheligeer C; Southern DA; Yan J; Wu G; Pan J; Lee S; Martin EA; Jafarpour H; Eastwood CA; Zeng Y; Quan H;

Objectives: Adverse event detection from Electronic Medical Records (EMRs) is challenging due to the low incidence of the event, variability in clinical documentation, and the complexity of data formats. Pulmonary embolism as an adverse event (PEAE) is particularly difficult to identify using exi ...

Article GUID: 40105654


Brain health PRO/Sante cerveau PRO: The development of a web-based program for dementia literacy and risk factor reduction

Author(s): Belleville S; Anderson ND; Bherer L; Camicioli R; Carrier J; Chan S; Cuesta M; Dang-Vu TT; Dwosh E; Fiocco AJ; Ferland G; Gilbert B; Harris E; Itzhak I; Jarrett P; Kadri MA; Laurin D; Liu-Ambrose T; McGibbon CA; Middleton L; Miller L; Ny ...

Background: Online educational programs focused on ways to improve brain health could increase participant literacy, empowerment, and engagement in activities that support personal brain health, potentially reducing dementia risk. Objectives: Our goal was to develop an evidence-based online educ ...

Article GUID: 40090784


Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer s disease

Author(s): Tremblay SA; Nathan Spreng R; Wearn A; Alasmar Z; Pirhadi A; Tardif CL; Chakravarty MM; Villeneuve S; Leppert IR; Carbonell F; Medina YI; Steele CJ; Gauthier CJ;

Early detection of pathological changes in Alzheimer's disease (AD) has garnered significant attention in the last few decades as interventions aiming to prevent progression will likely be most effective when initiated early. White matter (WM) alterations are among the earliest changes in AD, ...

Article GUID: 40086421


Automated abdominal aortic calcification scoring from vertebral fracture assessment images and fall-associated hospitalisations: the Manitoba Bone Mineral Density Registry

Author(s): Sim M; Gebre AK; Dalla Via J; Reid S; Jozani MJ; Kimelman D; Monchka BA; Gilani SZ; Ilyas Z; Smith C; Suter D; Schousboe JT; Lewis JR; Leslie WD;

Abdominal aortic calcification (AAC), a subclinical measure of cardiovascular disease (CVD) that can be assessed on vertebral fracture assessment (VFA) images during osteoporosis screening, is reported to be a falls risk factor. A limitation to incorporating AAC clinically is that its scoring req ...

Article GUID: 40080298


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