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Variations in perfusion detectable in advance of microstructure in white matter aging

Author(s): Robinson TD; Sun YL; Chang PTH; Gauthier CJ; Chen JJ;

One of the most promising interventional targets for brain health is cerebral perfusion, but its link to white matter (WM) aging remains unclear. Motivated by existing literature demonstrating links between declining cortical perfusion and the development of WM hyperintensities, we posit that regional WM hypoperfusion precedes deteriorating WM integrity. ...

Article GUID: 40694306


24-hour activity cycle behaviors and gray matter volume in mild cognitive impairment

Author(s): Balbim GM; Boa Sorte Silva NC; Falck RS; Kramer AF; Voss MW; Liu-Ambrose T;

Introduction: The 24-hour activity cycle (24-HAC) includes physical activity (PA), sedentary behavior (SB), and sleep. The 24-HAC composition and brain health relationship in adults with mild cognitive impairment (MCI) remains underexplored. We examined associations between 24-HAC composition and gray matter (GM) volume. Methods: Cross-sectional study in ...

Article GUID: 40693459


Evolution from the physical process-based approaches to machine learning approaches to predicting urban floods: a literature review

Author(s): Md Shike Bin Mazid Anik

Urban flooding has become a growing concern for many cities due to accelerating urbanisation, changing weather, and drainage system aging. Earlier studies of floods have taken primarily the traditional process-based approach to predicting urban floods, offering limited exploration of recent advancements in AI-driven, real-time, and community-integrated ap ...

Article GUID: 40692624


Wearable biosensors: A comprehensive overview

Author(s): Wu KY; Su ME; Kim Y; Nguyen L; Marchand M; Tran SD;

Wearable biosensors are revolutionizing the landscape of modern healthcare by enabling continuous, non-invasive monitoring and real-time diagnostics across a myriad of medical applications. This chapter provides a comprehensive overview of wearable biosensors, beginning with an exploration of their fundamental components, including biological elements, tr ...

Article GUID: 40683741


Advanced lithium-ion battery process manufacturing equipment for gigafactories: Past, present, and future perspectives

Author(s): Nekahi A; Feyzi E; Srivastava M; Yeganehdoust F; Madikere Raghunagtha Reddy AK; Zaghib K;

Lithium-ion battery cell manufacturing depends on a few key raw materials and equipment manufacturers. Battery manufacturing faces global challenges and opportunities as various regions, including Asia, Europe, North America, and emerging markets, seek to scale gigafactory production and innovate equipment manufacturing pathways. Regions can enhance batte ...

Article GUID: 40678540


A longitudinal person-centered analysis of anxiety sensitivity risk for young adult alcohol misuse: Examining the role of injunctive norms

Author(s): Corran C; Morin AJS; Hendershot CS; O' Connor RM;

Background: Alcohol use and problems increase during adolescence and peak in early adulthood. Tension reduction theory points to anxiety sensitivity as a risk factor for alcohol misuse, and the theory of planned behavior suggests that injunctive norms (i.e., perceived approval of risky drinking) may be central to this risk trajectory. Methods: This study ...

Article GUID: 40667852


Impact of different acute low back pain definitions on the predictors and on the risk of transition to chronic low back pain: a prospective longitudinal cohort study

Author(s): Osagie RO; Tufa I; Angarita-Fonseca A; Pagé MG; Lacasse A; Stone LS; Rainville P; Roy M; Tétreault P; Fortin M; Léonard G; Massé-Alarie H; Roy JS; Grant AV; Meloto CB;

Inconsistencies in the identification of predictors for the transition from acute low back pain (aLBP) to chronic LBP (cLBP) may be attributed to the varying definitions of aLBP used in different studies. We investigated how adopting different aLBP definitions affects the set of predictors and th ...

Article GUID: 40663110


Microfluidic Liquid Biopsy Minimally Invasive Cancer Diagnosis by Nano-Plasmonic Label-Free Detection of Extracellular Vesicles: Review

Author(s): Neriya Hegade KP; Bhat RB; Packirisamy M;

Cancer diagnosis requires alternative techniques that allow for early, non-invasive, or minimally invasive identification. Traditional methods, like tissue biopsies, are highly invasive and can be traumatic for patients. Liquid biopsy, a less invasive option, detects cancer biomarkers in body fluids such as blood and urine. However, early-stage cancer oft ...

Article GUID: 40650129


Assessment of cognitive load in the context of neurosurgery

Author(s): Di Giovanni DA; Kersten-Oertel M; Drouin S; Collins DL;

Purpose: Image-guided neurosurgery demands precise depth perception to minimize cognitive burden during intricate navigational tasks. Existing evaluation methods rely heavily on subjective user feedback, which can be biased and inconsistent. This study uses a physiological measure via electroencephalography (EEG), to quantify cognitive load when using nov ...

Article GUID: 40650801


Effect of a single dose of lorazepam on resting state functional connectivity in healthy adults

Author(s): Ferland MC; Wang R; Therrien-Blanchet JM; Remahi S; Côté S; Fréchette AJ; Dang-Vu TT; Liu H; Lepage JF; Théoret H;

Lorazepam is a fast-acting benzodiazepine that is widely used to manage anxiety symptoms through modulation of GABAergic activity. Despite being one of the most prescribed benzodiazepines, the effects of a single dose of lorazepam on brain functional connectivity at rest is not known. In this pla ...

Article GUID: 40646404


Sequencing of a Dairy Isolate Unlocks em Kluyveromyces marxianus /em as a Host for Lactose Valorization

Author(s): Thornbury M; Knoops A; Summerby-Murray I; Dhaliwal J; Johnson S; Utomo JC; Joshi J; Narcross L; Remondetto G; Pouliot M; Whiteway M; Martin VJJ;

The use of genetically modified nonconventional yeast provides significant potential for the bioeconomy by diversifying the tools available for the development of sustainable and novel products. In this study, we sequenced and annotated the genome of Kluyveromyces marxianus Y-1190 to establish it ...

Article GUID: 40629255


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