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Repurposing Sigma-1 Receptor-Targeting Drugs for Therapeutic Advances in Neurodegenerative Disorders

Author(s): Eskandari K; Bélanger SM; Lachance V; Kourrich S;

Neurodegenerative disorders, such as Alzheimer's, Parkinson's, and Huntington's disease, due to their multifaced and complicated nature, remain uncurable and impose substantial financial and human burdens on society. Therefore, developing new innovative therapeutic strategies is vital. In this context, drug repurposing has emerged as a promisi ...

Article GUID: 40430519


Machine learning innovations in CPR: a comprehensive survey on enhanced resuscitation techniques

Author(s): Islam S; Rjoub G; Elmekki H; Bentahar J; Pedrycz W; Cohen R;

This survey paper explores the transformative role of Machine Learning (ML) and Artificial Intelligence (AI) in Cardiopulmonary Resuscitation (CPR), marking a paradigm shift from conventional, manually driven resuscitation practices to intelligent, data-driven interventions. It examines the evolution of CPR through the lens of predictive modeling, AI-enha ...

Article GUID: 40336660


The Effect of the FIFA-11+ ACL Injury Prevention Program on Drop Vertical Jump Biomechanics in Varsity Athletes: A Prospective Observational Cohort Study

Author(s): Cierson T; Zhao K; Belkhelladi M; Babouras A; Jing J; Faith J; Corban J; Martineau PA;

Background: Anterior cruciate ligament (ACL) injuries can pose significant challenges for athletes, leading to significant morbidity, loss of playing time, and impaired performance. Neuromuscular training programs, such as the FIFA 11+, have shown promise in reducing the risk of lower extremity injuries in this high-risk population. Purpose/hypothesis: T ...

Article GUID: 40303320


PEDOT:PSS-MWCNT Nanocomposite Wire for Routing in Energy Harvesting Devices

Author(s): Shafagh SH; Deen I; Mamsapuram Panneerselvam D; Packirisamy M;

Polydimethylsiloxane (PDMS) and poly(3,4-ethylene dioxythiophene):poly(4-styrene-sulfonate) (PEDOT:PSS) composites were tested to determine their suitability for charging small-scale batteries in conjunction with a piezoelectric actuator as an energy harvester. Two different PEDOT:PSS patterns (zigzag and serpentine) were tested, and the maximum DC voltag ...

Article GUID: 40283259


Effect of Microstructure on Oxidation Resistance and TGO Formation in FeCoNiCrAl HEA Coatings Deposited by Low-Temperature HVAF Spraying

Author(s): Shahbazi H; Lima RS; Stoyanov P; Moreau C;

The effects of microstructure, density, and porosity of a FeCoNiCrAl high-entropy alloy (HEA) coating, fabricated using an internal diameter high-velocity air fuel (ID-HVAF) torch (model: i7 ID), on the isothermal oxidation behavior were investigated. This study pioneers the use of the ID-HVAF i7 ID system for HEA bond coat manufacturing, achieving a high ...

Article GUID: 40271745


Clustering and Interpretability of Residential Electricity Demand Profiles

Author(s): Kallel S; Amayri M; Bouguila N;

Efficient energy management relies on uncovering meaningful consumption patterns from large-scale electricity load demand profiles. With the widespread adoption of sensor technologies such as smart meters and IoT-based monitoring systems, granular and real-time electricity usage data have become available, enabling deeper insights into consumption behavio ...

Article GUID: 40218540


Strategies to Reduce Uncertainties from the Best Available Physicochemical Parameters Used for Modeling Novel Organophosphate Esters across Multimedia Environments

Author(s): Xing C; Ge J; Chen R; Li S; Wang C; Zhang X; Geng Y; Jones KC; Zhu Y;

Organophosphate esters (OPEs) raise growing environmental and human health concerns globally. However, numerous novel OPEs lack data on physicochemical properties, which are essential for assessing environmental fate, exposure, and risks. This study predicted water solubility (Sw), vapor pressure (Vp), octanol-water partition coefficient (Kow), and octano ...

Article GUID: 40105294


Elucidating the toxicity of methyl parathion, imazapic, isoxaflutole, and chlorantraniliprole on human hepatocarcinoma cells and bioinspired membranes

Author(s): Dos Santos DM; Rubira RJG; Salzedas GP; Kobal MB; Moreira LG; Toledo KA; Aoki PHB; DeWolf C; Camacho SA;

Pesticides have boosted agricultural productivity but pose significant risks to environmental and human health. The intensification of agriculture has driven widespread pesticide use, with 66 % of global consumption allocated to sugarcane, soybean and corn. Sugarcane, a major monoculture in Brazi ...

Article GUID: 40020292


Properties and Behavior of Sandy Soils by a New Interpretation of MICP

Author(s): Fukue M; Lechowicz Z; Mulligan CN; Takeuchi S; Fujimori Y; Emori K;

Research on MICP technology for ground improvement began in the early 2000s, and since then, it has been considered as innovative research. The field of applications is showing signs of expanding from sandy soil stabilization to remediation. However, the research has not always progressed, because it is extremely difficult to evaluate the ability (viabili ...

Article GUID: 40004331


5P Risk Classification Predicts Performance on Self-Reported but Not Objective Clinical Outcomes at 4-Weeks Post-Concussion in Children

Author(s): Teel E; Brossard-Racine M; Corbin-Berrigan LA; Gagnon I;

Objective: To determine if performance on symptom, cognitive, balance, fatigue, physical activity, and quality of life outcomes at 4-weeks post-injury in children with concussion differs based on acute 5P risk classification. Design: Prospective cohort. Setting: Laboratory. Patients: Sixty-two children (age: 13.27 ± 2.50 years; 29 (46.7%) females) with ...

Article GUID: 39988038


The PolyVent educational platform: An open mechanical ventilation platform for research and education

Author(s): Read RL; Bechard N; Suturin V; Zuiderwijk A; Mellenthin M;

The PolyVent is an open source mechanical ventilator meant for research and education. It prioritizes openness, modularity, repairability, and modifiability. An ESP32 microcontroller controls a proportional valve which precisely modulates pressure and flow from a mixing chamber into the airway. This chamber is fed with pressurized oxygen and medical air. ...

Article GUID: 39895909


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