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Is Adipose Tissue Inflammation the Culprit of Obesity-Associated Comorbidities?

Author(s): Turner L; Wanasinghe AI; Brunori P; Santosa S;

In individuals with obesity, the onset of chronic comorbidities coincides with the excessive accumulation of adipose tissue in various tissue beds. As obesity progresses, adipose tissue becomes increasingly dysfunctional causing chronic low-grade inflammation. Indeed, adipose tissue inflammation, which partially stems from macrophage infiltration and expr ...

Article GUID: 40533358


em Candida albicans /em : a historical overview of investigations into an important human pathogen

Author(s): Shrivastava M; Whiteway M;

In recent decades, the study of the opportunistic pathogenic fungus, Candida albicans, has been revolutionized by genomics, transforming our understanding of its molecular biology, pathogenicity, and modes of drug resistance. In this review, our effort is to trace the historical development of C. albicans research, from early clinical observations to mode ...

Article GUID: 40522159


Visual Features in Stereo-Electroencephalography to Predict Surgical Outcome: A Multicenter Study

Author(s): Abdallah C; Thomas J; Aron O; Avigdor T; Jaber K; Doležalová I; Mansilla D; Nevalainen P; Parikh P; Singh J; Beniczky S; Kahane P; Minotti L; Chabardes S; Colnat-Coulbois S; Maillard L; Hall J; Dubeau F; Gotman J; Grova C; Frauscher B;

Objective: Epilepsy surgery needs predictive features that are easily implemented in clinical practice. Previous studies are limited by small sample sizes, lack of external validation, and complex computational approaches. We aimed to identify and validate visually stereo-electroencephalography ( ...

Article GUID: 40519108


In vitro evaluation of isatin-pyridine oxime hybrids as potential acetylcholinesterase inhibitors for nerve agent prophylaxis

Author(s): Silva MCJD; Pinto AMV; Balthar MA; Correa ABA; Bhattacharyya D; Simas ABC; Kuca K; Forgione P; França TCC; Cavalcante SFA; Kitagawa DAS;

Given the recent deployment of nerve agents as a method of warfare and in targeted assassinations, the development of robust, broad-spectrum medical countermeasures is essential. Our research group has synthesized isatin-pyridine oxime hybrids that have previously demonstrated the ability to resc ...

Article GUID: 40516590


Viral Voices: Depictions of Women s Pain Experiences on Social Media

Author(s): Mazzocca K; Langmuir T; Manan J; Gagnon MM; Alberts NM;

TikTok is a popular social media platform increasingly used to disseminate health information and personal experiences, including among women with pain. Characterising health-related content can help understand how public perceptions are shaped and guide improvements in patient care. Although women with pain often seek information on social media, little ...

Article GUID: 40514002


Sustainable Recovery of Critical Minerals from Wastes by Green Biosurfactants: A Review

Author(s): Deravian B; Mulligan CN;

Biosurfactants have emerged as promising agents for environmental remediation due to their ability to complex, chelate, and remove heavy metals from contaminated environments. This review evaluates their potential for recovering critical minerals from waste materials to support renewable energy production, emphasizing the role of biosurfactant-metal inter ...

Article GUID: 40509347


Evaluation of Protein Cards: A nutrition education tool for metabolic bariatric surgery

Author(s): Acosta PFC; Heidl AJ; Angeles PM; Farnesi BC; Alcindor P; Alberga AS; Erdstein J; Saputra S; Cohen TR;

Background: Metabolic bariatric surgery (MBS) is a safe, effective treatment for severe obesity and its associated comorbidities. However, adherence to postoperative guidelines, particularly dietary protein intake remains a challenge. This study examined the suitability of the Protein Cards, a pr ...

Article GUID: 40504806


Effects of Audiovisual Cues on Game Immersion during Simulated Slot Machine Gambling

Author(s): Arshad F; Ferrari MA; Murch WS; Cherkasova MV; Limbrick-Oldfield EH; Winstanley CA; Clark L;

Modern slot machines can create immersive experiences for gamblers. Design features, including audiovisual cues, may influence these experiences, potentially interacting with personal risk factors for disordered gambling. According to the incentive salience hypothesis of addiction, reward-paired ...

Article GUID: 40504292


Morphological characteristics of the thoracolumbar fascia: relationship to chronic low back pain and back extension strength

Author(s): Caron FP; Martin Smith C; Naghdi N; Iorio OC; Bertrand C; Fortin M;

Purpose: The purpose of this study was to investigate the relationship between different characteristics of the Thoracolumbar Fascia (TLF) (e.g., length, epimuscular fat distribution) with pain status and lumbar extension strength in a sample of participants with and without chronic low back pain (CLBP). Methodology: This cross-sectional study included 2 ...

Article GUID: 40498329


Before hands disappear: Effect of early warning visual feedback method for hand tracking failures in virtual reality

Author(s): Gemici M; Phadnis V; Batmaz AU;

Virtual hand representation in Head-Mounted Displays (HMDs) offers immersive and intuitive interactions in Virtual Reality (VR). However, current hand tracking algorithms are prone to errors, which can disrupt the user experience and hinder task performance. This paper presents a novel method for providing users with visual feedback when the quality of ha ...

Article GUID: 40493551


Ultrasound and MRI-based evaluation of relationships between morphological and mechanical properties of the lower lumbar multifidus muscle in chronic low back pain

Author(s): Naghdi N; Masi S; Bertrand C; Rosenstein B; Cohen-Adad J; Rivaz H; Roy M; Fortin M;

Purposes: While lumbar multifidus (MF) muscle alterations are linked to low back pain (LBP), the structure-function relationship is not fully understood. This study aims to evaluate the relationship between fatty degeneration of the lumbar MF muscle and its function in individuals with and without LBP. Methods: The study included 25 participants with chr ...

Article GUID: 40488869


What is the role of non-surgical clinicians in the assessment and management of degenerative cervical myelopathy? - Insights from the RECODE-DCM peri-operative rehabilitation incubator

Author(s): Chauhan RV; Demetriades AK; Boerger TF; Lantz JM; Treanor C; Kalsi-Ryan S; Kumar V; Wood L; Plener J; Wilson N; Fortin M; Ammendolia C; Paus A; Dhillon RS; Davies B; Fehlings MG; Anderson DB;

Introduction: Evidence on degenerative cervical myelopathy (DCM) has frequently focussed on surgical management, overlooking the role of non-surgical clinicians. Their contributions in the patient journey remain largely underexplored in the literature. Research question: What is the role of non- ...

Article GUID: 40487873


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