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O4 -Alkylated-2-Deoxyuridine Repair by O6 -Alkylguanine DNA Alkyltransferase is Augmented by a C5-Fluorine Modification

Author(s): Lauralicia Sacre

Oligonucleotides containing various adducts, including ethyl, benzyl, 4-hydroxybutyl and 7-hydroxyheptyl groups, at the O4 atom of 5-fluoro-O4 -alkyl-2'-deoxyuridine were prepared by solid-phase synthesis. UV thermal denaturation studies demonstrated that these modifications destabilised the duplex by approximately 10 °C, relative to the control con ...

Article GUID: 29243336


Differences in Riverine and Pond Water Dissolved Organic Matter Composition and Sources in Canadian High Arctic Watersheds Affected by Active Layer Detachments.

Author(s): Wang JJ, Lafrenière MJ, Lamoureux SF, Simpson AJ, Gélinas Y, Simpson MJ

Environ Sci Technol. 2018 Feb 06;52(3):1062-1071 Authors: Wang JJ, Lafrenière MJ, Lamoureux SF, Simpson AJ, Gélinas Y, Simpson MJ

Article GUID: 29301070


Smart Self-Assembled Nanosystem Based on Water-Soluble Pillararene and Rare-Earth-Doped Upconversion Nanoparticles for pH-Responsive Drug Delivery.

Author(s): Li H, Wei R, Yan GH, Sun J, Li C, Wang H, Shi L, Capobianco JA, Sun L

ACS Appl Mater Interfaces. 2018 Feb 07;10(5):4910-4920 Authors: Li H, Wei R, Yan GH, Sun J, Li C, Wang H, Shi L, Capobianco JA, Sun L

Article GUID: 29336139


Metabolism and pharmacokinetics of a potent N-acylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) in rats and monkeys.

Author(s): Reddy CN, Alhamza H, Chourey S, Ye Q, Gore V, Cossette C, Gravel S, Slobodchikova I, Vuckovic D, Rokach J, Powell WS

Eur J Pharm Sci. 2018 Mar 30;115:88-99 Authors: Reddy CN, Alhamza H, Chourey S, Ye Q, Gore V, Cossette C, Gravel S, Slobodchikova I, Vuckovic D, Rokach J, Powell WS

Article GUID: 29339225


Cation-π Interactions between Quaternary Ammonium Ions and Amino Acid Aromatic Groups in Aqueous Solution

Author(s): Esam A Orabi

Cation-p interactions play important roles in the stabilization of protein structures and protein-ligand complexes. They contribute to the binding of quaternary ammonium ligands (mainly RNH(3)^(+) and RN(CH(3))(3)^(+)) to various protein receptors and are likely involved in the blockage of potassium channels by tetramethylammonium (TMA^(+)) and tetraeth ...

Article GUID: 29397727


In vitro studies of disease-linked variants of human tRNA nucleotidyltransferase reveal decreased thermal stability and altered catalytic activity.

Author(s): Leibovitch M, Hanic-Joyce PJ, Joyce PBM

Biochim Biophys Acta Proteins Proteom. 2018 Apr;1866(4):527-540 Authors: Leibovitch M, Hanic-Joyce PJ, Joyce PBM

Article GUID: 29454993


Cinnamomum zeylanicum bark essential oil induces cell wall remodelling and spindle defects in Candida albicans.

Author(s): Shahina Z, El-Ganiny AM, Minion J, Whiteway M, Sultana T, Dahms TES

Fungal Biol Biotechnol. 2018;5:3 Authors: Shahina Z, El-Ganiny AM, Minion J, Whiteway M, Sultana T, Dahms TES

Article GUID: 29456868


Microfluidic Assembly To Synthesize Dual Enzyme/Oxidation-Responsive Polyester-Based Nanoparticulates with Controlled Sizes for Drug Delivery.

Author(s): Hong SH, Patel T, Ip S, Garg S, Oh JK

Langmuir. 2018 03 13;34(10):3316-3325 Authors: Hong SH, Patel T, Ip S, Garg S, Oh JK

Article GUID: 29485889


Modeling Protein S-Aromatic Motifs Reveals Their Structural and Redox Flexibility

Author(s): Esam A Orabi

S-aromatic motifs are important noncovalent forces for protein stability and function but remain poorly understood. Hence, we performed quantum calculations at the MP2(full)/6-311++G(d,p) level on complexes between Cys (H(2)S, MeSH) and Met (Me(2)S) models with models of Phe (benzene, toluene), Trp (indole, 3-methylindole), Tyr (phenol, 4-methylphenol), ...

Article GUID: 29533644


Investigating the selectivity of potential new inhibitors of dihydrofolate reductase from Yersinia pestis designed by molecular modeling.

Author(s): Bastos LDC, de Souza FR, Pereira Souza LM, Forgione P, Cuya T, de Alencastro RB, Pimentel AS, Celmar Costa França T

J Biomol Struct Dyn. 2019 Mar;37(5):1170-1176 Authors: Bastos LDC, de Souza FR, Pereira Souza LM, Forgione P, Cuya T, de Alencastro RB, Pimentel AS, Celmar Costa França T PMID: 29542379 [PubMed - in process]

Article GUID: 29542379


Large-scale dewetting assembly of gold nanoparticles for plasmonic enhanced upconversion nanoparticles.

Author(s): Clarke C, Liu D, Wang F, Liu Y, Chen C, Ton-That C, Xu X, Jin D

Nanoscale. 2018 Apr 05;10(14):6270-6276 Authors: Clarke C, Liu D, Wang F, Liu Y, Chen C, Ton-That C, Xu X, Jin D

Article GUID: 29560984


Liquid chromatography - high resolution mass spectrometry method for monitoring of 17 mycotoxins in human plasma for exposure studies

Author(s): Slobodchikova I; Vuckovic D;

Mycotoxins are secondary metabolites produced by filamentous fungi. Primary route of human exposure to mycotoxins is the intake of the contaminated food. Minimizing mycotoxin exposure is important for population health, as their chronic toxic effects have been associated with kidney and liver diseases, some types of cancer and immunosuppression. The obj ...

Article GUID: 29576275


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