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Sperm histone H3 lysine 4 trimethylation is altered in a genetic mouse model of transgenerational epigenetic inheritance

Author(s): Lismer A; Siklenka K; Lafleur C; Dumeaux V; Kimmins S;

Advancing the molecular knowledge surrounding fertility and inheritance has become critical given the halving of sperm counts in the last 40 years, and the rise in complex disease which cannot be explained by genetics alone. The connection between both these trends may lie in alterations to the sperm epigenome and occur through environmental exposures. Ch ...

Article GUID: 33068438


Circulating miR-1246 Targeting UBE2C, TNNI3, TRAIP, UCHL1 Genes and Key Pathways as a Potential Biomarker for Lung Adenocarcinoma: Integrated Biological Network Analysis

Author(s): Huang S; Wei YK; Kaliamurthi S; Cao Y; Nangraj AS; Sui X; Chu D; Wang H; Wei DQ; Peslherbe GH; Selvaraj G; Shi J;

Analysis of circulating miRNAs (cmiRNAs) before surgical operation (BSO) and after the surgical operation (ASO) has been informative for lung adenocarcinoma (LUAD) diagnosis, progression, and outcomes of treatment. Thus, we performed a biological network analysis to identify the potential target ...

Article GUID: 33050659


The Covert and Overt Reassurance Seeking Inventory (CORSI): Development, validation and psychometric analyses.

Author(s): Radomsky AS, Neal RL, Parrish CL, Lavoie SL, Schell SE

BACKGROUND: Reassurance seeking (RS) is motivated by perceived general and social/relational threats across disorders, yet is often under-recognized because it occurs in covert (i.e. subtle) and overt forms. Covert safety-seeking behaviour may maintain disorders by preventing corrective learning and is therefore important to identify effectively. AIMS: Th ...

Article GUID: 33046164


Integrative Dance for Adults with Down Syndrome: Effects on Postural Stability.

Author(s): Dipasquale S, Canter B, Roberts M

Postural stability, one's ability to maintain an upright stable position, is a crucial aspect of functional mobility and independent living. The purpose of this study was to examine if integrative dance classes have the potential to improve the postural stability in individuals with Down syndrome (DS). Utilizing a one group design, seven participants ...

Article GUID: 33042366


Grape seed extract supplementation along with a restricted-calorie diet improves cardiovascular risk factors in obese or overweight adult individuals: A randomized, placebo-controlled trial.

Author(s): Yousefi R, Parandoosh M, Khorsandi H, Hosseinzadeh N, Madani Tonekaboni M, Saidpour A, Babaei H, Ghorbani A

Grape seed extract (GSE) is a flavonoid-rich supplement, recently discussed as a potential moderator of inflammation and obesity. In this study, we aimed to investigate the effects of GSE supplementation along with a restricted-calorie diet (RCD), on changes in blood lipid profile, visceral adipo ...

Article GUID: 33044768


Dissemination and analysis of the quality assurance (QA) and quality control (QC) practices of LC-MS based untargeted metabolomics practitioners

Author(s): Evans AM; O' Donovan C; Playdon M; Beecher C; Beger RD; Bowden JA; Broadhurst D; Clish CB; Dasari S; Dunn WB; Griffin JL; Hartung T; Hsu PC; Huan T; Jans J; Jones CM; Kachman M; Kleensang A; Lewis MR; Monge ME; Mosley JD; Taylor E; ...

Introduction: The metabolomics quality assurance and quality control consortium (mQACC) evolved from the recognized need for a community-wide consensus on improving and systematizing quality assurance (QA) and quality control (QC) practices for untargeted metabolomics. Objectives: In this work, ...

Article GUID: 33044703


Is It Time for Aerobic Exercise to be Included in Asthma Treatment Guidelines?

Author(s): Bacon SL, Platts-Mills TAE

J Allergy Clin Immunol Pract. 2020 Oct; 8(9):2997-2998 Authors: Bacon SL, Platts-Mills TAE PMID: 33039014 [PubMed - as supplied by publisher]

Article GUID: 33039014


Adaptation to pitch-altered feedback is independent of one's own voice pitch sensitivity.

Author(s): Alemi R, Lehmann A, Deroche MLD

Monitoring voice pitch is a fine-tuned process in daily conversations as conveying accurately the linguistic and affective cues in a given utterance depends on the precise control of phonation and intonation. This monitoring is thought to depend on whether the error is treated as self-generated or externally-generated, resulting in either a correction or ...

Article GUID: 33033324


A threshold LC-MS/MS method for 92 analytes in oral fluid collected with the Quantisal® device

Author(s): Desharnais B; Lajoie MJ; Laquerre J; Mireault P; Skinner CD;

A study of impaired driving rates in the province of Québec is currently planned following the legalization of recreational cannabis in Canada. Oral fluid (OF) samples are to be collected with a Quantisal® device and sent to the laboratory for analysis. In order to prepare for this project, a qualitative decision point analysis method monitoring for the p ...

Article GUID: 33035929


Adaptive behaviour under conflict: deconstructing extinction, reversal, and active avoidance learning.

Author(s): Manning EE, Bradfield LA, Iordanova MD

In complex environments, organisms must respond adaptively to situations despite conflicting information. Under natural (i.e. non-laboratory) circumstances, it is rare that cues or responses are consistently paired with a single outcome. Inconsistent pairings are more common, as are situations where cues and responses are associated with multiple outcomes ...

Article GUID: 33035525


Salt-Dependent Interactions between the C-Terminal Domain of Osmoregulatory Transporter ProP of Escherichia coli and the Lipid Membrane

Author(s): Ozturk TN; Culham DE; Tempelhagen L; Wood JM; Lamoureux G;

Osmosensing transporter ProP detects the increase in cytoplasmic cation concentration associated with osmotically induced cell dehydration and mediates osmolyte uptake into bacteria. ProP is a 12-transmembrane helix protein with an a-helical, cytoplasmic C-terminal domain (CTD) linked to transmembrane helix XII (TM XII). It has been proposed that the CTD ...

Article GUID: 32838524


On a local (de-)trapping model for highly doped Pr3+ radioluminescent and persistent luminescent nanoparticles

Author(s): Mandl GA; Van der Heggen D; Cooper DR; Joos JJ; Seuntjens J; Smet PF; Capobianco JA;

Trivalent praseodymium exhibits a wide range of luminescent phenomena when doped into a variety of different materials. Herein, radioluminescent NaLuF4:20%Pr3+ nanoparticles are studied. Four different samples of this composition were prepared ranging from 400-70 nm in size. Kinetic studies of radioluminescence as a function of X-ray irradiation time reve ...

Article GUID: 33030192


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