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Mechanisms of hypericin incorporation to explain the photooxidation outcomes in phospholipid biomembrane models

Author(s): Pereira LSA; Camacho SA; Almeida AM; Gonçalves RS; Caetano W; DeWolf C; Aoki PHB;

Cell membranes are the first barriers for drug binding and key for the action of photosensitizers (PS). Herein, we report on the incorporation of the PS hypericin into Langmuir monolayers of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS), to represen ...

Article GUID: 35167859


Progesterone rapidly alters the use of place and response memory during spatial navigation in female rats

Author(s): Lacasse JM; Patel S; Bailey A; Peronace V; Brake WG;

17ß-Estradiol (E2) and progesterone (P) influence place and response memory in female rats in spatial navigation tasks. Use of these memory systems is associated with the hippocampus and the dorsal striatum, respectively. Injections of E2 result in a well-established bias to use place memory, while much less is understood about the role of P. A total of 1 ...

Article GUID: 35158200


Metabolism of anti-inflammatory OXE (oxoeicosanoid) receptor antagonists by nonhuman primates

Author(s): Cossette C; Chourey S; Ye Q; Reddy CN; Wang R; Poulet S; Slobodchikova I; Vuckovic D; Rokach J; Powell WS;

5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is the only product of the proinflammatory 5-lipoxygenase pathway with potent chemoattractant effects for human eosinophils, suggesting an important role in eosinophilic diseases such as asthma. 5-Oxo-ETE, acting through its selective OXE receptor ...

Article GUID: 35158054


Neutral and adaptive drivers of genomic change in introduced brook trout (Salvelinus fontinalis) populations revealed by pooled sequencing

Author(s): Brookes B; Jeon HB; Derry AM; Post JR; Rogers SM; Humphries S; Fraser DJ;

Understanding the drivers of successful species invasions is important for conserving native biodiversity and for mitigating the economic impacts of introduced species. However, whole-genome resolution investigations of the underlying contributions of neutral and adaptive genetic variation in successful introductions are rare. Increased propagule pressure ...

Article GUID: 35154655


Hetero-architectured core-shell NiMoO4@Ni9S8/MoS2 nanorods enabling high-performance supercapacitors

Author(s): Chen L; Deng W; Chen Z; Wang X;

Abstract: An effective technique for improving electrochemical efficiency is to rationally design hierarchical nanostructures that completely optimize the advantages of single components and establish an interfacial effect between structures. In this study, core-shell NiMoO4@Ni9S8/MoS2 hetero-structured nanorods are prepared via a facile hydrothermal proc ...

Article GUID: 35153374


Diffuse optical reconstructions of functional near infrared spectroscopy data using maximum entropy on the mean

Author(s): Zhengchen Cai

Functional near-infrared spectroscopy (fNIRS) measures the hemoglobin concentration changes associated with neuronal activity. Diffuse optical tomography (DOT) consists of reconstructing the optical density changes measured from scalp channels to the oxy-/deoxy-hemoglobin concentration changes within the cortical regions. In the present study, we adapted ...

Article GUID: 35145148


Compound changes in temperature and snow depth lead to asymmetric and nonlinear responses in landscape freeze-thaw

Author(s): Hatami S; Nazemi A;

Cycles of freeze-thaw (FT) are among the key landscape processes in cold regions. Under current global warming, understanding the alterations in FT characteristics is of a great importance for advising land management strategies in northern latitudes. Using a generic statistical approach, we address the impacts of compound changes in air temperature and s ...

Article GUID: 35140288


Feasibility and preliminary efficacy of the LEAD trial: a cluster randomized controlled lifestyle intervention to improve hippocampal volume in older adults at-risk for dementia

Author(s): N D Koblinsky

CONCLUSIONS: High adherence and retention rates were observed among participants and preliminary findings illustrate improvements in diet quality and HbA1c. These results indicate that a larger trial is feasible if difficulties surrounding recruitment can be mitigated.

Article GUID: 35139918


Validation of an Adapted Version of the Glasgow Anxiety Scale for People with Intellectual Disabilities (GAS-ID)

Author(s): Maïano C; Morin AJS; Gagnon C; Olivier E; Tracey D; Craven RG; Bouchard S;

The objective of the study was to validate adapted versions of the Glasgow Anxiety Scale for people with Intellectual Disabilities (GAS-ID) simultaneously developed in English and French. A sample of 361 youth with mild to moderate intellectual disability (ID) (M = 15.78 years) from Australia (English-speaking) and Canada (French-speaking) participated in ...

Article GUID: 35138559


Neuropsychological deficits in patients with cognitive complaints after COVID-19

Author(s): García-Sánchez C; Calabria M; Grunden N; Pons C; Arroyo JA; Gómez-Anson B; Lleó A; Alcolea D; Belvís R; Morollón N; Mur I; Pomar V; Domingo P;

Background: While much of the scientific focus thus far has been on cognitive sequelae in patients with severe COVID-19, subjective cognitive complaints are being reported across the spectrum of disease severity, with recent studies beginning to corroborate patients' perceived deficits. In re ...

Article GUID: 35137561


Warm and arid regions of the world are hotspots of superorganism complexity

Author(s): La Richelière F; Muñoz G; Guénard B; Dunn RR; Economo EP; Powell S; Sanders NJ; Weiser MD; Abouheif E; Lessard JP;

Biologists have long been fascinated by the processes that give rise to phenotypic complexity of organisms, yet whether there exist geographical hotspots of phenotypic complexity remains poorly explored. Phenotypic complexity can be readily observed in ant colonies, which are superorganisms with ...

Article GUID: 35135345


The rodent medial prefrontal cortex and associated circuits in orchestrating adaptive behavior under variable demands

Author(s): Howland JG; Ito R; Lapish CC; Villaruel FR;

Emerging evidence implicates rodent medial prefrontal cortex (mPFC) in tasks requiring adaptation of behavior to changing information from external and internal sources. However, the computations within mPFC and subsequent outputs that determine behavior are incompletely understood. We review the involvement of mPFC subregions, and their projections to th ...

Article GUID: 35131398


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