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Miniaturized scalable arrayed CRISPR screening in primary cells enables discovery at the single donor resolution

Author(s): Patel MA; Boribong BP; Sinha H; Xiao B; Xie K; Vo PQN; Chin AB; Ellouzi A; Little SR; Shih S; Wu H; Muller WJ; Hirukawa A;

High-efficiency gene editing in primary human cells is critical for advancing therapeutic development and functional genomics, yet conventional electroporation platforms often require high cell input and are poorly suited to parallelized experiments. Here we introduce a next-generation digital mi ...

Article GUID: 40790054


Multi-label classification for biomedical literature: an overview of the BioCreative VII LitCovid Track for COVID-19 literature topic annotations

Author(s): Chen Q; Allot A; Leaman R; Islamaj R; Du J; Fang L; Wang K; Xu S; Zhang Y; Bagherzadeh P; Bergler S; Bhatnagar A; Bhavsar N; Chang YC; Lin SJ; Tang W; Zhang H; Tavchioski I; Pollak S; Tian S; Zhang J; Otmakhova Y; Yepes AJ; Dong H; Wu H; ...

The coronavirus disease 2019 (COVID-19) pandemic has been severely impacting global society since December 2019. The related findings such as vaccine and drug development have been reported in biomedical literature-at a rate of about 10 000 articles on COVID-19 per month. Such rapid growth signif ...

Article GUID: 36043400


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