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Importin-β1 functions as a chromatin sensor to position the contractile ring for cytokinesis

Author(s): Brancheriau CR; Larocque K; Schick G; Tountas I; Perlman A; Piekny A;

Cytokinesis, the final step of cell division, relies on ingression of a precisely positioned actomyosin ring. Chromatin-associated Ran-GTP fine-tunes ring position, although the mechanism remains unclear. We hypothesize that depletion of Ran-GTP between segregating chromosomes leads to equatorial enrichment of importins, promoting recruitment of the sca ...

Article GUID: 42225064


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