Author(s): LeCocq MR; Mainville-Berthiaume A; Laplante I; Samaha AN;

Background: Reward-associated cues guide reward-seeking behaviours. These cues include conditioned stimuli (CSs), which occur following seeking actions and predict reward delivery, and discriminative stimuli (DSs), which occur response-independently and signal that a seeking action will produce reward. Metabotropic group II glutamate (mGlu2/3) receptors i ...

Article GUID: 40341317

Author(s): Ndiaye NA; Shamleh SA; Casale D; Castaneda-Ouellet S; Laplante I; Robinson MJF; Samaha AN;

Rationale: When people with drug addiction encounter cues associated with drug use, this can trigger cravings and relapse. These cues can include conditioned stimuli (CSs) signaling drug delivery and discriminative stimuli (DSs) signaling drug availability. Compared to CS effects, DS effects are ...

Article GUID: 38767684

Author(s): Servonnet A, Minogianis EA, Bouchard C, Bédard AM, Lévesque D, Rompré PP, Samaha AN

Neuropharmacology. 2017 Sep 01;123:10-21 Authors: Servonnet A, Minogianis EA, Bouchard C, Bédard AM, Lévesque D, Rompré PP, Samaha AN

Article GUID: 28522313

Author(s): Minogianis EA; Shams WM; Mabrouk OS; Wong JT; Brake WG; Kennedy RT; du Souich P; Samaha AN;

The faster drugs of abuse reach the brain, the greater is the risk of addiction. Even small differences in the rate of drug delivery can influence outcome. Infusing cocaine intravenously over 5 vs. 90-100 s promotes sensitization to the psychomotor and incentive motivational effects of the drug a ...

Article GUID: 29757478