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Global survey of secondary metabolism in em Aspergillus niger /em via activation of specific transcription factors

Author(s): Semper C; Pham TTM; Ram S; Palys S; Evdokias G; Ouedraogo JP; Moisan MC; Geoffrion N; Reid I; Di Falco M; Bailey Z; Tsang A; Benoit-Gelber I; Savchenko A;

Genomics analysis confirmed the status of filamentous fungi as a rich source of novel secondary metabolites; however, the discovery of these compounds is hampered by the cryptic nature of their biosynthetic pathways under laboratory conditions. Consequently, despite substantial research effort ov ...

Article GUID: 40852424


A portrait of online gambling: a look at a transformation amid a pandemic

Author(s): Kairouz S; Savard AC; Murch WS; Dixon MR; Martin NB; Brodeur M; Dauphinais S; Ferland F; Hamel D; Dufour M; French M; Monson E; Van Mourik V; Morvannou A;

Background: The COVID-19 pandemic brought about an extraordinary societal context in which the gambling offer was modified to meet public health measures intended to curb viral transmission. With many land-based gambling venues being forced to close, gambling opportunities were left almost exclus ...

Article GUID: 40770758


Guide de pratique clinique pour la prise en charge de l obésité chez l enfant

Author(s): Ball GDC; Merdad R; Birken CS; Cohen TR; Goodman B; Hadjiyannakis S; Hamilton J; Henderson M; Lammey J; Morrison KM; Moore SA; Mushquash AR; Patton I; Pearce N; Ramjist JK; Lebel TR; Timmons BW; Buchholz A; Cantwell J; Cooper J; Erdstein ...

id="fra-abstract"> Contexte: L’obésité est une maladie chronique complexe et stigmatisante caractérisée par une accumulation anormale ou excessive de graisse corporelle susceptible de nuire à la santé, d’accroître le risque de complications médicales et de réduire l’espérance de vie des ...

Article GUID: 40721241


Inferring concussion history in athletes using pose and ground reaction force estimation and stability analysis of plyometric exercise videos

Author(s): Alves W; Babouras A; Martineau PA; Schutt D; Robbins S; Fevens T;

Concussions present a significant risk to athletes, with females exhibiting higher rates and prolonged recovery times than males. Current sideline concussion detection methods, such as the King-Devick test commonly used as a rapid screening tool designed to evaluate eye movement, attention, language, and cognitive processing abilities suffer from validity ...

Article GUID: 40632382


Ten new insights in climate science 2024

Author(s): Schaeffer R; Schipper ELF; Ospina D; Mirazo P; Alencar A; Anvari M; Artaxo P; Biresselioglu ME; Blome T; Boeckmann M; Brink E; Broadgate W; Bustamante M; Cai W; Canadell JG; Cardinale R; Chidichimo MP; Ditlevsen P; Eicker U; Feron S; Fik ...

The years 2023 and 2024 were characterized by unprecedented warming across the globe, underscoring the urgency of climate action. Robust science advice for decision makers on subjects as complex as climate change requires deep cross- and interdisciplinary understanding. However, navigating the ev ...

Article GUID: 40546753


Visual Features in Stereo-Electroencephalography to Predict Surgical Outcome: A Multicenter Study

Author(s): Abdallah C; Thomas J; Aron O; Avigdor T; Jaber K; Doležalová I; Mansilla D; Nevalainen P; Parikh P; Singh J; Beniczky S; Kahane P; Minotti L; Chabardes S; Colnat-Coulbois S; Maillard L; Hall J; Dubeau F; Gotman J; Grova C; Frauscher B;

Objective: Epilepsy surgery needs predictive features that are easily implemented in clinical practice. Previous studies are limited by small sample sizes, lack of external validation, and complex computational approaches. We aimed to identify and validate visually stereo-electroencephalography ( ...

Article GUID: 40519108


Biopsychosocial risk factors for pain in early phases of pediatric cancer treatment

Author(s): Klages KL; James RN; Kain ZN; Phipps S; Alberts NM; Fortier MA;

Introduction: Cancer pain remains a significant burden among children with cancer, and many patients experience pain starting around the time of diagnosis and throughout the course of treatment. A biopsychosocial treatment approach has been recommended to improve pain management in this population; however, specific psychosocial factors that contribute to ...

Article GUID: 40365620


An Effective and Fast Model for Characterization of Cardiac Arrhythmia and Congestive Heart Failure

Author(s): Lahmiri S; Bekiros S;

Background/Objectives: Cardiac arrhythmia (ARR) and congestive heart failure (CHF) are heart diseases that can cause dysfunction of other body organs and possibly death. This paper describes a fast and accurate detection system to distinguish between ARR and normal sinus (NS), and between CHF and NS. Methods: the proposed automatic detection system uses t ...

Article GUID: 40218199


Improving diacetylene photopolymerization in monolayers and ultrathin films

Author(s): Ji J; Li Y; Bernaerts S; Mali KS; Ding R; Lin H; Cuccia LA; De Feyter S; Ivasenko O; Chi L; Fang Y;

Gentle annealing and photopolymerization under inert atmospheres strongly enhance the quality of polydiacetylene monolayers. These simple measures not only triple the average degree of polymerization but also alter the preferred photoexcitation mode and cause pronounced nano-alignment during the early stages of polymerization.

Article GUID: 40171944


Mirtazapine for chronic insomnia in older adults: a randomised double-blind placebo-controlled trial-the MIRAGE study

Author(s): Nguyen PV; Dang-Vu TT; Forest G; Desjardins S; Forget MF; Vu TT; Nguyen QD; Kouassi E; Desmarais P;

Background: Mirtazapine promotes sleep by blocking serotonin and histaminergic receptors and is often used off-label to treat chronic insomnia. However, its efficacy remains to be demonstrated in a clinical trial. The MIRAGE study aims to determine the efficacy and safety of mirtazapine in older ...

Article GUID: 40135470


Correlations of pilot trainees brainwave dynamics with subjective performance evaluations: insights from EEG microstate analysis

Author(s): Zhao M; Law A; Su C; Jennings S; Bourgon A; Jia W; Larose MH; Bowness D; Zeng Y;

Objective: This study aims to investigate the relationship between the subjective performance evaluations on pilot trainees' aircraft control abilities and their brainwave dynamics reflected in the results from EEG microstate analysis. Specifically, we seek to identify correlations between distinct microstate patterns and each dimension included in th ...

Article GUID: 40109507


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