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Perceptions of carbon dioxide emission reductions and future warming among climate experts

Author(s): Wynes S; Davis SJ; Dickau M; Ly S; Maibach E; Rogelj J; Zickfeld K; Matthews HD;

The Intergovernmental Panel on Climate Change (IPCC) employs emission scenarios to explore a range of future climate outcomes but refrains from assigning probabilities to individual scenarios. However, IPCC authors have their own views on the likelihood of ...

Article GUID: 39280638


Comparative genomic analysis of thermophilic fungi reveals convergent evolutionary adaptations and gene losses

Author(s): Steindorff AS; Aguilar-Pontes MV; Robinson AJ; Andreopoulos B; LaButti K; Kuo A; Mondo S; Riley R; Otillar R; Haridas S; Lipzen A; Grimwood ...

Thermophily is a trait scattered across the fungal tree of life, with its highest prevalence within three fungal families (Chaetomiaceae, Thermoascaceae, and Trichocomaceae), as well as some member ...

Article GUID: 39266695


Show me the evidence to guide nutrition practice: Scoping review of macronutrient dietary treatments after metabolic and bariatric surgery

Author(s): Parrott JM; Benson-Davies S; O' Kane M; Sherf-Dagan S; Ben-Porat T; Arcone VM; Faria SL; Parrott JS; ...

Background: Clinical practice recommendations for macronutrient intake in Metabolic and Bariatric Surgery (MBS) are insufficiently grounded in the research, possibly due to a pauci ...

Article GUID: 39262138


The perceived social support of parents having bipolar disorder impacts their children's mental health: a 10-year longitudinal study

Author(s): Trespalacios F; Boyle A; Serravalle L; Hodgins S; Ellenbogen MA;

Background: The offspring of parents with bipolar disorder (OBD) are at higher risk of developing psychopathology than the offspring of parents with no affective disorder (control). In addition to genetic predisposition, childhood adversity and a stressful ...

Article GUID: 39066987


A Survey on Error Exponents in Distributed Hypothesis Testing: Connections with Information Theory, Interpretations, and Applications

Author(s): Espinosa S; Silva JF; Céspedes S;

A central challenge in hypothesis testing (HT) lies in determining the optimal balance between Type I (false positive) and Type II (non-detection or false negative) error probabilities. Analyzing these errors' exponential rate of convergence, known as e ...

Article GUID: 39056958


A spatial perturbation framework to validate implantation of the epileptogenic zone

Author(s): Jaber K; Avigdor T; Mansilla D; Ho A; Thomas J; Abdallah C; Chabardes S; Hall J; Minotti L; Kahane P; Grova C; Gotman J; Frauscher B; ...

Stereo-electroencephalography (SEEG) is the gold standard to delineate surgical targets in focal drug-resistant epilepsy. SEEG uses electrodes placed directly into the brain to identify the seizure ...

Article GUID: 38897997


Discovery and preclinical development of a therapeutically active nanobody-based chimeric antigen receptor targeting human CD22

Author(s): McComb S; Arbabi-Ghahroudi M; Hay KA; Keller BA; Faulkes S; Rutherford M; Nguyen T; Shepherd A; Wu C; Marcil A; Aubry A; Hussack G; Pinto DM ...

Chimeric antigen receptor (CAR) T cell therapies targeting B cell-restricted antigens CD19, CD20, or CD22 can produce potent clinical responses for some B cell malignancies, but relapse remains com ...

Article GUID: 38596311


Strategies used during the cognitive evaluation of older adults with dual sensory impairment: a scoping review

Author(s): Dumassais S; Pichora-Fuller MK; Guthrie D; Phillips NA; Savundranayagam M; Wittich W;

Background: Dual sensory impairment (DSI), the combination of visual and hearing impairments, is associated with increased risk for age-related cognitive decline and dementia. Administering cognitive tests to individuals with sensory impairment is challengi ...

Article GUID: 38506649


A chloromethyl-triazole fluorescent chemosensor for O6-methylguanine DNA methyltransferase

Author(s): Ayan S; Rotaru AM; Kaye EG; Juneau G; Das S; Wilds CJ; Beharry AA;

Fluorescent chemosensors offer a direct means of measuring enzyme activity for cancer diagnosis, predicting drug resistance, and aiding in the discovery of new anticancer drugs. O6-methylguanine DNA methyltransferase (MGMT) is a predictor of resistance towa ...

Article GUID: 38502038


Primates and disability: Behavioral flexibility and implications for resilience to environmental change

Author(s): Stewart BM; Joyce MM; Creeggan J; Eccles S; Gerwing MG; Turner SE;

Congenital malformations, conditions, injuries, and illness can lead to long-term physical impairment and disability in nonhuman primates. How individual primates change their behaviors flexibly to compensate for their disabilities can inform our understand ...

Article GUID: 38050800


A multilevel mHealth intervention boosts adherence to hydroxyurea in individuals with sickle cell disease

Author(s): Hankins JS; Brambilla D; Potter MB; Kutlar A; Gibson RW; King AA; Baumann AA; Melvin CL; Gordeuk VR; Hsu LL; Nwosu C; Porter JS; Alberts NM; ...

Hydroxyurea reduces sickle cell disease (SCD) complications, but medication adherence is low. We tested two mobile health (mHealth) interventions targeting determinants of low adherence among patie ...

Article GUID: 37738155


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