Author(s): Neriya Hegade KP; Bhat RB; Packirisamy M;

Cancer diagnosis requires alternative techniques that allow for early, non-invasive, or minimally invasive identification. Traditional methods, like tissue biopsies, are highly invasive and can be traumatic for patients. Liquid biopsy, a less invasive option, detects cancer biomarkers in body fluids such as blood and urine. However, early-stage cancer oft ...

Article GUID: 40650129

Author(s): Yazdanpanah Moghadam E; Sonenberg N; Packirisamy M;

Amyloid beta oligomers (AßO) are pivotal in Alzheimer's Disease (AD), cleared by microglia cells, as immune cells in the brain. Microglia cells exposed to AßO are involved with migration, apoptosis, phagocytosis, and activated microglial receptors through AßO, impacting cellular mechanobiological characteristics such as microglial adhesion strength to ...

Article GUID: 40623989

Author(s): Foroughi S; Karamzadeh V; Habibi M; Packirisamy M;

Direct sound printing (DSP) is a recent development in additive manufacturing processes using sound waves, in which cavitation bubbles created by a focused ultrasound field polymerize the liquid resin via the sonochemistry route. This article presents the first attempt to create functional parts, such as cantilevers and millifluidic systems in polydimethy ...

Article GUID: 40538575

Author(s): Shafagh SH; Deen I; Mamsapuram Panneerselvam D; Packirisamy M;

Polydimethylsiloxane (PDMS) and poly(3,4-ethylene dioxythiophene):poly(4-styrene-sulfonate) (PEDOT:PSS) composites were tested to determine their suitability for charging small-scale batteries in conjunction with a piezoelectric actuator as an energy harvester. Two different PEDOT:PSS patterns (zigzag and serpentine) were tested, and the maximum DC voltag ...

Article GUID: 40283259

Author(s): Yazdanpanah Moghadam E; Sonenberg N; Packirisamy M;

Microglial cells, or brain immune cells, are highly dynamic and continuously migrate in pathophysiological conditions. Their adhesion, as a physical characteristic, plays a key role in migration. In this study, we presented a microfluidic chip combination of two assays: a microglial BV2 adhesion assay and a wound-healing migration assay. The chip could cr ...

Article GUID: 39203655

Author(s): Derayatifar M; Habibi M; Bhat R; Packirisamy M;

Direct sound printing (DSP), an alternative additive manufacturing process driven by sonochemical polymerization, has traditionally been confined to a single acoustic focal region, resulting in a voxel-by-voxel printing approach. To overcome this limitation, we introduce holographic direct sound printing (HDSP), where acoustic holograms, storing cross-sec ...

Article GUID: 39107289

Author(s): Yazdanpanah Moghadam E; Sonenberg N; Packirisamy M;

Microglia cells, as the resident immune cells of the central nervous system (CNS), are highly motile and migratory in development and pathophysiological conditions. During their migration, microglia cells interact with their surroundings based on the various physical and chemical properties in the brain. Herein, a microfluidic wound-healing chip is develo ...

Article GUID: 36832056

Author(s): Pou KRJ; Raghavan V; Packirisamy M;

The increasing trend in ensuring safe and quality foods necessitates the monitoring of food products throughout the food supply chain. Food packaging is an indispensable process as it provides various functions such as containment, protection, convenience, and communication. The development of innovative packaging systems is required to ensure foods are m ...

Article GUID: 36192908

Author(s): Sohrabi Kashani A; Larocque K; Piekny A; Packirisamy M;

In the present study, we investigate the mechanobiological responses of human lung cancer that may occur through their interactions with two different types of gold nanoparticles: nanostars and nanospheres. Hyperspectral images of nanoparticle-treated cells revealed different spatial distributions of nanoparticles in cells depending on their morphology, w ...

Article GUID: 35839330

Author(s): Raju D; Bathini S; Badilescu S; Ghosh A; Packirisamy M;

Extracellular vesicles (EVs) are a group of communication organelles enclosed by a phospholipid bilayer, secreted by all types of cells. The size of these vesicles ranges from 30 to 1000 nm, and they contain a myriad of compounds such as RNA, DNA, proteins, and lipids from their origin cells, offering a good source of biomarkers. Exosomes (30 to 100 nm) a ...

Article GUID: 35630197

Author(s): Habibi M; Foroughi S; Karamzadeh V; Packirisamy M;

Photo- and thermo-activated reactions are dominant in Additive Manufacturing (AM) processes for polymerization or melting/deposition of polymers. However, ultrasound activated sonochemical reactions present a unique way to generate hotspots in cavitation bubbles with extraordinary high temperature and pressure along with high heating and cooling rates whi ...

Article GUID: 35387993