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Assessing in silico tools for accurate pathogenicity prediction in CHD nucleosome remodelers

Author(s): Rabouhi N; Guindon S; Coleman EA; van Heesbeen HJ; Greenwood CMT; Lu T; Campeau PM;

Chromodomain Helicase DNA-binding (CHD) proteins compose a family of chromatin remodelers that play crucial roles in DNA repair and gene expression regulation, neural stem cell differentiation and chromatin integrity. Genetic variants in CHD chromatin remodelers are associated with neurodevelopmental disorders with features like autism spectrum disorder a ...

Article GUID: 40907936


A historical perspective on porphyrin-based metal-organic frameworks and their applications

Author(s): Zhang X; Wasson MC; Shayan M; Berdichevsky EK; Ricardo-Noordberg J; Singh Z; Papazyan EK; Castro AJ; Marino P; Ajoyan Z; Chen Z; Islamoglu T; Howarth AJ; Liu Y; Majewski MB; Katz MJ; Mondloch JE; Farha OK;

Porphyrins are important molecules widely found in nature in the form of enzyme active sites and visible light absorption units. Recent interest in using these functional molecules as building blocks for the construction of metal-organic frameworks (MOFs) have rapidly increased due to the ease in ...

Article GUID: 33678810


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