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Mapping cerebral blood perfusion and its links to multi-scale brain organization across the human lifespan

Author(s): Farahani A; Liu ZQ; Ceballos EG; Hansen JY; Wennberg K; Zeighami Y; Dadar M; Gauthier CJ; Dagher A; Misic B;

Blood perfusion delivers oxygen and nutrients to all cells, making it a fundamental feature of brain organization. How cerebral blood perfusion maps onto micro-, meso- and macro-scale brain structure and function is therefore a key question in neuroscience. Here we analyze pseudo-continuous arter ...

Article GUID: 40729400


Benchmarking macaque brain gene expression for horizontal and vertical translation

Author(s): Luppi AI; Liu ZQ; Hansen JY; Cofre R; Niu M; Kuzmin E; Froudist-Walsh S; Palomero-Gallagher N; Misic B;

The spatial patterning of gene expression shapes cortical organization and function. The macaque is a fundamental model organism in neuroscience, but the translational potential of macaque gene expression rests on the assumption that it is a good proxy for patterns of corresponding proteins (vert ...

Article GUID: 40020056


Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain

Author(s): Hansen JY; Markello RD; Tuominen L; Nørgaard M; Kuzmin E; Palomero-Gallagher N; Dagher A; Misic B;

Neurotransmitter receptors modulate signaling between neurons. Thus, neurotransmitter receptors and transporters play a key role in shaping brain function. Due to the lack of comprehensive neurotransmitter receptor/transporter density datasets, microarray gene expression measuring mRNA transcript ...

Article GUID: 36209794


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