Author(s): Soucy JP; Belasso CJ; Cai Z; Bezgin G; Stevenson J; Rahmouni N; Tissot C; Lussier FZ; Rosa-Neto P; Rivaz HJ; Benali H;

Background: Tau aggregates in Alzheimer's disease (AD) induce loss of synapses and neurons, leading to cognitive impairment. Predicting tau and neurodegeneration temporal evolution could be used for prognostication and for assessing results of therapeutic trials. Tau PET and MRI volumetry are ...

Article GUID: 39782975

Author(s): Soucy JP; Belasso CJ; Cai Z; Bezgin G; Stevenson J; Rahmouni N; Tissot C; Lussier FZ; Rosa-Neto P; Rivaz HJ; Benali H;

Background: Tau aggregates in Alzheimer's disease (AD) induce loss of synapses and neurons, leading to cognitive impairment. Predicting tau and neurodegeneration temporal evolution could be used for prognostication and for assessing results of therapeutic trials. Tau PET and MRI volumetry are ...

Article GUID: 39784152

Author(s): Gao Z; Chen X; Xu J; Yu R; Zhang H; Yang J;

Drowsy driving is a leading cause of commercial vehicle traffic crashes. The trend is to train fatigue detection models using deep neural networks on driver video data, but challenges remain in coarse and incomplete high-level feature extraction and network architecture optimization. This paper pioneers the use of the CLIP (Contrastive Language-Image Pre- ...

Article GUID: 39771685

Author(s): Lima BS; Rosa-Neto P; Phillips N; Borrie M; Roncero CT; Lahiri D; Dori D; Chertkow H;

Background: A growing body of research has focused on inflammation as both a potential biomarker and a risk factor for Alzheimer's disease (AD). The cytokine Interleukin-6 (IL-6) is involved in the pathogenesis of inflammatory disorders and in the physiological homeostasis of neural tissue. AD has been associated with increased IL-6 expression in brai ...

Article GUID: 39751468

Author(s): Sforza M; Morin CM; Dang-Vu TT; Pomares FB; Perrault AA; Gouin JP; Bušková J; Janku K; Vgontzas A; Fernandez-Mendoza J; Bastien CH; Riemann D; Baglioni C; Carollo G; Casoni F; Zucconi M; Castronovo V; Galbiati A; Ferini-Strambi L;

Investigating the mechanisms of action of cognitive-behavioural therapy for insomnia (CBT-I), the first-line treatment for chronic insomnia disorder (ID), can contribute to the overall understanding of insomnia and its treatment. To date, no study has examined the relationship between K-complexes ...

Article GUID: 39739397

Author(s): Parmar V; Orabi EA; English AM; Peslherbe GH;

Nitroglycerin is a potent vasodilator in clinical use since the late 1800s. It functions as a prodrug that is bioactivated by formation of an enzyme-based thionitrate, E-Cys-NO2. This intermediate reportedly decomposes to release NO and NO2- but their relative yields remain controversial. Hence, we determined barriers for NO and NO2- production from the m ...

Article GUID: 39738238

Author(s): Spiegler P; Abdelsalam H; Hellum O; Hadjinicolaou A; Weil AG; Xiao Y;

Epilepsy is a neurological disorder characterized by recurring seizures that can cause a wide range of symptoms. Stereo-electroencephalography (SEEG) is a diagnostic procedure where multiple electrodes are stereotactically implanted within predefined brain regions to identify the seizure onset zone, which needs to be surgically removed or disconnected to ...

Article GUID: 39735694

Author(s): Bernos TA; Gibelli J; Michaelides S; Won H; Jeon HB; Marin K; Boguski DA; Janjua MY; Gallagher CP; Howland KL; Fraser DJ;

Intraspecific variation is important for species' long-term persistence in changing environments. Conservation strategies targeting intraspecific variation often rely on the identification of management or policy units below the species level based on biological differences among populations. ...

Article GUID: 39730611

Author(s): Yusefi H; Helfield B;

Clinical ultrasound contrast agent microbubbles remain intravascular and are between 1-8 µm in diameter, with a volume-weighted mean size of 2-3 µm. Despite their worldwide clinical utility as a diagnostic contrast agent, and their continued and ongoing success as a local therapeutic vector, the fundamental interplay between microbubbles - including bubbl ...

Article GUID: 39705920

Author(s): Bai Y; Xu Y; Sun L; Ward Z; Wang H; Ratnayake G; Wang C; Zhao M; He H; Gao J; Wu M; Lu S; Bepete G; Peng D; Liu B; Kang F; Terrones H; Terrones M; Lei Y;

Liquid exfoliation is a scalable and effective method for synthesizing 2D nanosheets (NSs) but often induces contamination and defects. Here, liquid metal gallium (Ga) is used to exfoliate bulk layered materials into 2D NSs at near room temperature, utilizing the liquid surface tension and Ga int ...

Article GUID: 39707650

Author(s): Bi H; Wang Z; Yue R; Sui J; Mulligan CN; Lee K; Pegau S; Chen Z; An C;

Coastal areas of the Arctic and Subarctic are vulnerable to accidental oil spills, impacting the ecosystem, society, and economy. This article provides a comprehensive overview of oil spill pollution issues in cold regions, focusing on environmental impacts, oil transport and fate, coastal/shoreline response measures, and the state of current internationa ...

Article GUID: 39689468