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Miniaturized scalable arrayed CRISPR screening in primary cells enables discovery at the single donor resolution

Author(s): Patel MA; Boribong BP; Sinha H; Xiao B; Xie K; Vo PQN; Chin AB; Ellouzi A; Little SR; Shih S; Wu H; Muller WJ; Hirukawa A;

High-efficiency gene editing in primary human cells is critical for advancing therapeutic development and functional genomics, yet conventional electroporation platforms often require high cell input and are poorly suited to parallelized experiments. Here we introduce a next-generation digital mi ...

Article GUID: 40790054


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