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The PREVENT-AD cohort: accelerating Alzheimer s disease research and treatment in Canada and beyond

Author(s): Villeneuve S; Poirier J; Breitner JCS; Tremblay-Mercier J; Remz J; Raoult JM; Yakoub Y; Gallego-Rudolf J; Qiu T; Valdez AF; Mohammediyan B; Javanray M; Metz A; Sanami S; Ourry V; Wearn A; Pastor-Bernier A; Edde M; Gonneaud J; Strikwerda- ...

The PREVENT-AD is an investigator-driven study that was created in 2011 and enrolled cognitively normal older adults with a family history of sporadic AD. Participants are deeply phenotyped and have now been followed annually for more than 12 years [median follow-up 8.0 years,SD 3.1]. Multimodal ...

Article GUID: 40778177


Use of lecanemab and donanemab in the Canadian healthcare system: Evidence, challenges, and areas for future research

Author(s): Smith EE; Phillips NA; Feldman HH; Borrie M; Ganesh A; Henri-Bhargava A; Desmarais P; Frank A; Badhwar A; Barlow L; Bartha R; Best S; Bethell J; Bhangu J; Black SE; Bocti C; Bronskill SE; Burhan AM; Calon F; Camicioli R; Campbell B; Coll ...

Lecanemab and donanemab are monoclonal antibody therapies that remove amyloid-beta from the brain. They are the first therapies that alter a fundamental mechanism, amyloid-beta deposition, in Alzheimer disease (AD). To inform Canadian decisions on approval and use of these drugs, the Canadian Con ...

Article GUID: 39893139


Impact of a national dementia research consortium: The Canadian Consortium on Neurodegeneration in Aging (CCNA)

Author(s): Chertkow H; Phillips N; Rockwood K; Anderson N; Andrew MK; Bartha R; Beaudoin C; Bélanger N; Bellec P; Belleville S; Bergman H; Best S; Bethell J; Bherer L; Black S; Borrie M; Camicioli R; Carrier J; Cashman N; Chan S; Crowshoe L; Cuello ...

The Canadian Consortium on Neurodegeneration in Aging (CCNA) was created by the Canadian federal government through its health research funding agency, the Canadian Institutes for Health Research (CIHR), in 2014, as a response to the G7 initiative to fight dementia. Two five-year funding cycles ( ...

Article GUID: 39636028


Dehydroepiandrosterone impacts working memory by shaping cortico-hippocampal structural covariance during development.

Author(s): Nguyen TV, Wu M, Lew J, Albaugh MD, Botteron KN, Hudziak JJ, Fonov VS, Collins DL, Campbell BC, Booij L, Herba C, Monnier P, Ducharme S, McCracken JT

Psychoneuroendocrinology. 2017 Dec;86:110-121 Authors: Nguyen TV, Wu M, Lew J, Albaugh MD, Botteron KN, Hudziak JJ, Fonov VS, Collins DL, Campbell BC, Booij L, Herba C, Monnier P, Ducharme S, McCracken JT

Article GUID: 28946055


Age-specific associations between oestradiol, cortico-amygdalar structural covariance, and verbal and spatial skills.

Author(s): Nguyen TV, Jones SL, Gower T, Lew J, Albaugh MD, Botteron KN, Hudziak JJ, Fonov VS, Louis Collins D, Campbell BC, Booij L, Herba CM, Monnier P, Ducharme S, Waber D, McCracken JT

J Neuroendocrinol. 2019 Apr;31(4):e12698 Authors: Nguyen TV, Jones SL, Gower T, Lew J, Albaugh MD, Botteron KN, Hudziak JJ, Fonov VS, Louis Collins D, Campbell BC, Booij L, Herba CM, Monnier P, Ducharme S, Waber D, McCracken JT

Article GUID: 30776161


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