1 G.E.S. and G.J. Network On Risks, Quality and Sustainable Environment, University of Caen Normandy, Caen, France.
2 A.A. Medicine, Agronomy, Nutrition, KS, USA.
3 M.A. Genetics & Toxicology, King's College London, London, UK.
4 M.A. Toxicology, Albert Einstein College of Medicine, Bronx, NY, USA.
5 M.-H.B. Sociologie, Université du Québec à Montréal, Montreal, Canada.
6 M.B. Biochemistry, Vannes, France.
7 T.B., Institute for Marine Research, Tromso, Norway.
8 M.L.B. Endocrine Physiology and Metabolism Laboratory, UNIOESTE, Cascavel, Brazil.
9 E.B. Soil Microbiology, Sölden, Germany.
10 N.D. Zoology, IICAR-CONICET-UNR, Campo Experimental Villarino, Zavalla, Santa Fe, Argentina.
11 R.D. Animal Biology, Abbes Laghrour Khenchela University, Khenchela, Algeria.
12 J.L.D. Toxicology, Universitat Rovira i Virgili, Reus, Spain.
13 J.D. Nutrition, Spark-Vie, Barjac, France.
14 J.F. Molecular Biology, Health Research Institute, Fairfield Iowa, USA.
15 T.F. Placenta, INSERM, Université Paris Cité, Paris, France.
16 J.L.Y.G. Environment, Faculty of Environmental Sciences, University of Castilla-La Mancha, Toledo, Spain.
17 S.G., Placenta, Faculté de Pharmacie, Université Paris Cité, Paris, France.
18 P. H-G., Agroecology, Normandy, France.
19 A.H., Environmental Systems Science, ETH Zurich, Switzerland.
20 L.H. Sustainable Dev., Knowledge Center for Sustainable Development, University of Zurich, Zurich, Switzerland.
21 D.H. Plant Physiology, Purdue University, West Lafayette, USA.
22 H.J. Cancérologie, Université de Montpellier, Montpellier, France.
23 I.K. Zoology, Abdul Wali Khan University Mardan, Mardan, Pakistan.
24 D.K. Toxicology, University of Thessaly, Larissa, Greece.
25 F.L. Sociologie, University of Caen Normandy, Caen, France.
26 U.L. Human Ecology, University of Edinburgh, Edinburgh, Scotland.
27 G.L. Epistemology, CNRS, Ecole Normale Supérieure, Paris, France.
28 R.M. Physiology, Buchinger Wilhelmi Clinic, Überlingen, Germany.
29 D.I. N. Toxicology, University of Crete, Heraklion, Greece.
30 J.-M. P. Microbiologist, Network On Risks, University of Caen Normandy, Caen, France.
31 C.P. Environmental Health, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
32 C.R. Environment, GMWatch, Brighton, UK.
33 C.S. Biodiversity & Conservation, Institute of Organismic Biology, University of Bonn, Bonn, Germany.
34 D.S. ENSSER, Nijmegen, Netherlands.
35 C.S. Pediatric Endocrinology, University of Montpellier, Montpellier, France.
36 A.T. Toxicology, University of Crete, Heraklion, Greece.
37 L.V. Environnemental Sciences, Université du Québec à Montréal, Montreal, Canada.
38 N-F. W. Chemical Biology, East China University of Science and Technology, Shangai, China.
39 B.W., Risk Assessment, Lancaster University, Lancaster, UK.
40 J.G.Z. Zoology, Boku University, Vienna, Austria.
41 A. Z.-S. Placenta, UMR-S 1139, Santé, Université Paris Cité, Paris, France.
42 X.Z. Environmental Chemistry, Concordia University, Montreal, Canada.

We propose a new paradigm, as toxicology currently lacks the proper perspective. From the 1950s to the 1970s, at least one-third of all toxicological testing in the United States, including for chemicals and drugs, was misleading scientists, and this worldwide issue persists today. Moreover, petroleum-based waste and heavy metals have been discovered in pesticide and plasticizer formulations. These contaminations have now reached all forms of life. Widespread exposure to chemical mixtures promotes health and environmental risks. We discovered that pesticides have never undergone long-term testing on mammals in their full commercial formulations by regulatory authorities or the pesticide industry; instead, only their declared active ingredients have been assessed, contrary to environmental law recommendations. The ingredients of these formulations are not fully disclosed, yet the formulations are in general at least 1000 times more toxic at low environmentally relevant doses than the active ingredients alone under conditions of long-term exposure. A similar lack of comprehensive toxicological evaluation applies to plasticizers. Their regulatory authorisations might have been obtained by incomplete, misleading and potentially false input data. This has profound implications not only for scientific knowledge, but also for public and environmental health. We propose pragmatically a paradigm shift in regulation: 1/to lower the ADI of polluting substances by at least a factor of 100 for already authorized products; 2/for new compounds, the obligation to test the full pesticide formulations in vivo chronically at environmentally relevant levels. This is necessary because pesticides are synthesized from petroleum, which can contain heavy metals. Moreover, formulated pesticides can contain plasticizers. The declared active substance, as an isolated compound of this mixture chosen by the company, will not have to be tested by itself alone. Compensation could be organized for pesticide use reduction, this will save health and environmental degradation; 3/the complete toxicological raw data for individual animals should be published on the Internet, including the precise protocols by which they were obtained, and they must be accessible for the scientific community, including students. There is no reason to keep these data secret. Implementing these changes would also support the advancement of agroecological alternatives.