Author(s): Comeau P; Leite ML; Manso A;

The main objective of this study was to develop a natural curcumin-loaded varnish that responds to blue light in an antimicrobial photodynamic therapy-based approach with photoelimination of targeted cells. Fluoride-free curcumin-loaded varnish (CUR-V) consisting of gum rosin (80 wt%) and ethanol (20 wt%) was loaded with 0, 0.25, and 10.0 wt% curcumin and ...

Article GUID: 40387395

Author(s): Leite ML; Comeau P; Zaghwan A; Shen Y; Manso AP;

Objectives: This study aimed to assess the potential of experimental dental resins containing ZnO nanoparticles (ZnO-NPs) for antimicrobial photodynamic therapy (aPDT) as a functional tool for the modulation of cariogenic biofilm in long-term. Methods: Minimum inhibitory and bactericidal concentrations (MIC/MBC) of ZnO-NPs against Streptococcus mutans we ...

Article GUID: 39765362

Author(s): Leite ML; Comeau P; Aghakeshmiri S; Lange D; Rodrigues LKA; Branda N; Manso AP;

Background: Streptococcus mutans and Candida albicans are associated with caries recurrence. Therefore, this study evaluated the combination of a Ru(II)-loaded resin-based dental material (RDM) and antimicrobial photodynamic therapy (aPDT) against a dual-species biofilm of S. mutans and C. albicans. Methods: An aPDT protocol was established evaluating Ru ...

Article GUID: 38395246

Author(s): Comeau P; Manso A;

Dental caries is a highly preventable and costly disease. Unfortunately, the current management strategies are inadequate at reducing the incidence and new minimally invasive strategies are needed. In this study, a systematic evaluation of specific light parameters and aqueous curcumin concentrations for antimicrobial photodynamic therapy (aPDT) was condu ...

Article GUID: 38140048