Author(s): Sanami S; Tremblay SA; Rezaei A; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ;

Coronary artery disease (CAD), the leading cause of mortality worldwide, is increasingly recognized for its impact on brain health and cognition, yet the mechanisms linking CAD to vascular and metabolic alterations in the brain remain poorly understood. Prior work has identified regional deficits ...

Article GUID: 41452711

Author(s): Paez A; Gillman SO; Dogaheh SB; Carnes A; Dakterzada F; Barbe F; Dang-Vu TT; Piñol-Ripoll G;

Background: Sleep plays vital roles in brain-health and cognition, including regulating clearance of ß-amyloid (Aß) and tau proteins that hallmark Alzheimer's disease (AD). Changes in sleep physiology can predate cognitive symptoms by decades in AD, but it remains unclear which sleep characte ...

Article GUID: 41452500

Author(s): Marinou S; Phillips NA;

Background: Subjective cognitive decline (SCD) is defined as a self-perceived decline in cognition without objective cognitive impairment and is considered a potential predictor of Alzheimer's disease (AD). However, summary-level neuropsychological test scores often fail to detect subtle cognitive changes in this group, making assessments challenging. ...

Article GUID: 41448190

Author(s): Cunningham NP; Tremblay-Mercier J; Baril AA; Dang-Vu TT; Lim A; Geddes MR; Badawy M; Poirier J; Ducharme S; Villeneuve S;

Background: Poor sleep is a modifiable factor associated with the development and progression of Alzheimer's Disease (AD). Pharmacological treatments and Cognitive Behavioural Therapy for Insomnia (CBT-I) which promote sleep have the potential to improve AD risk profile. In addition, prior re ...

Article GUID: 41450269

Author(s): Rehan S; Mehrabi F; Mick P; Phillips NA;

Background: Sensory and psychosocial factors are potentially modifiable risk factors for dementia. Social factors and indicators of mental health are associated with cognitive performance and risk for Alzheimer's disease (AD). Sensory impairment can lead to communication and mobility difficulties, reducing social engagement and possibly accelerating c ...

Article GUID: 41447555

Author(s): Sorin C; Phillips NA;

Background: During the COVID-19 pandemic, older adults were considered vulnerable to declines in well-being, especially those with preexisting cognitive impairments. However, qualitative studies have focused on the resilience of cognitively-unimpaired older adults during the pandemic. Therefore, the present study employed both quantitative and qualitative ...

Article GUID: 41447242

Author(s): Jobin B; Frasnelli J; Phillips NA; Boller B;

Background: Olfactory identification is impaired early in the clinical continuum of Alzheimer's disease (AD) and is already observable in mild cognitive impairment (MCI). A recent meta-analysis showed significant associations between olfactory identification and episodic memory scores in older adults without cognitive impairment. Thus, olfactory ident ...

Article GUID: 41443638

Author(s): Grant N; Phillips NA;

Background: Age-related hearing loss (HL) is associated with poorer cognition and increased risk of developing dementia. However, few studies have explored if sex affects the association between HL and cognition. We investigated the relationship between two hearing measures and performance on cognitive screening and neuropsychological tests in males and f ...

Article GUID: 41443651

Author(s): Kouzoukas E; Navas C; Zawertailo L; Fougere C; Bacon SL; Chadi N; Evans WK; McNeill A; Melamed O; Moraes TJ; Nnorom O; Schwartz R; Shahab L; Ween M; Selby P;

Objective: To develop evidence-informed recommendations on the health effects of e-cigarettes to guide healthcare practitioners and the public to balance individual and population harm reduction. Methods: Systematic and umbrella reviews investigating the health effects of e-cigarette use were co ...

Article GUID: 41443121

Author(s): Silva NCBS; Stein RG; Gu Y; Hsu CL; Tam RC; Salluzzi M; McCreary CR; Alkeridy WA; Lam K; MacKay AL; Kolind S; Cossette B; Griffith LE; Hogan DB; McMillan JM; Raina P; Smith EE; Liu-Ambrose T;

Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of COVID-19 and has infected >700 million persons worldwide. Individuals infected with SARS-CoV-2 are at risk for cognitive decline and at higher risk of dementia compared with those diagnosed with oth ...

Article GUID: 41434542

Author(s): Silva NCBS; Balbim GM; Stein RG; Gu Y; Tam RC; Dao E; Alkeridy WA; Kramer AF; Liu-Ambrose T;

Background: Physical activity is associated with higher myelin content in older individuals with cerebral small vessel disease (CSVD), a condition marked by demyelination. However, potential mechanisms underlying these associations remain understudied. High-density lipoprotein (HDL) is involved i ...

Article GUID: 41435075