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Does Intranasal Oxytocin Reduce Symptoms of Mental Disorders? A Meta-Analysis of Clinical Trials

Author(s): Bonnieux J; Gumuchian ST; Harboun A; Trespalacios F; Bélisle KA; Haddad A; Quintus-Bosz O; McLellan A; Chester-Trudel L; Garred D; Resendes T; Hazel L; Wong SF; Ellenbogen MA;

Intranasal administration of oxytocin has been shown to enhance social cognition and reduce stress reactivity in healthy individuals, suggesting therapeutic potential for mental disorders. However, clinical trials have produced mixed results. Following a systematic search, data were extracted fro ...

Article GUID: 42134427


Resistance training and subcortical vascular cognitive impairment: A 12-month randomized trial

Author(s): Liu-Ambrose T; Falck RS; Dao E; Crockett RA; Barha CK; Silva NCBS; Alkeridy WA; Best JR; Hsiung GR; Field TS; Madden KM; Davis JC; Ten Brinke LF; Tam RC;

Introduction: It is unknown whether progressive resistance training (PRT) improves cognitive function in adults with cerebral small vessel disease and mild cognitive impairment (i.e., subcortical vascular cognitive impairment [SVCI]). Methods: We conducted a 12-month randomized trial comparing P ...

Article GUID: 41795685


A randomized controlled trial of an acceptance-based, insight-inducing medication adherence therapy (AIM-AT) for adults with early-stage psychosis

Author(s): Chien WT; Chong YY; Bressington D; McMaster CW;

This study aimed to test the effectiveness of an acceptance-based medication adherence intervention for people with early-stage psychosis. An assessor-blind, three-arm randomized controlled trial design was used. One hundred and twenty-six participants who were adults with =3 years of psychosis were recruited from four district Integrated Community Center ...

Article GUID: 38908265


An international, Delphi consensus study to identify priorities for methodological research in behavioral trials in health research.

Author(s): Byrne M, McSharry J, Meade O, Lavoie KL, Bacon SL

Trials. 2020 Mar 23;21(1):292 Authors: Byrne M, McSharry J, Meade O, Lavoie KL, Bacon SL

Article GUID: 32293510


Group sample sizes in nonregulated health care intervention trials described as randomized controlled trials were overly similar

Author(s): Thombs BD; Levis AW; Azar M; Saadat N; Riehm KE; Sanchez TA; Chiovitti MJ; Rice DB; Levis B; Fedoruk C; Lyubenova A; Malo Vázquez de Lara AL; Kloda LA; Benedetti A; Shrier I; Platt RW; Kimmelman J;

Objectives: We evaluated whether sample sizes in different arms of two-arm parallel group randomized controlled trials of nonregulated interventions were systematically closer in size than would plausibly occur by chance if simple randomization had been applied. Study design and setting: We sear ...

Article GUID: 31866472


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